Global ETD Search
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Showing 1 to 16 of 16 for “"drug repositioning"”.
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Drug discovery against malaria parasite: drug repositioning strategy
… year and there are ever present problems due to drug resistance. In this work, I used drug-repositioning strategy with bisphosphonates to discover a lead that is active against malaria in vivo. The developmental procedures include, in vitro high throughput screening, x-ray crystallography and …
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Drug repositioning and indication discovery using description logics
Drug repositioning is the discovery of new indications for approved or failed drugs. This practice is commonly done within the drug discovery process in order to adjust or expand the application line of an active molecule. Nowadays, an increasing number of computational methodologies aim at …
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Ontology-based methods for disease similarity estimation and drug repositioning
… early disease diagnosis and development of new drugs. The growing collection of gene-function and gene-disease data has instituted a need for formal knowledge representation in order to extract information. Ontologies have been successfully applied to represent such knowledge, and data mining …
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Lead optimisation of dehydroemetine as an antimalarial option through drug repositioning and molecular modelling
… There is a great need for new anti-malarial drugs, but traditional drug discovery timelines take approximately 10-17 years. Drug repositioning offers a very effective alternative to de novo drug design and could minimise the long timescales involved in the process of bringing a drug to the …
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A medicinal chemistry approach to drug repositioning in the treatment of tuberculosis and malaria
… deaths every year. A number of efficacious drugs are available for the treatment of TB and malaria, which, through various combination therapies, are fully effective in treating these diseases. However, the wide spread resistance in M. tuberculosis (Mtb) and P. falciparum, the causative …
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Identifying drug-target and drug-disease associations using computational intelligence
Background: Traditional drug development is an expensive process that typically requires the investment of a large number of resources in terms of finances, equipment, and time. However, sometimes these efforts do not result in a pharmaceutical product in the market. To overcome the limitations of …
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Accelerating antimalarial drug discovery through repositioning
… measures have been hampered by the emergence of drug resistance to most antimalarial therapies. Early signs of drug resistance to the current frontline option, the artemisinins, make it imperative that novel drug candidates are discovered. One possible short-term solution is drug repositioning, …
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Investigating calcium channel blockers as antimalarials
The rise in resistance to current antimalarial drugs has led researchers to consider drug repositioning as a quicker alternative for drug development and discovery. Preliminary drug repositioning screens carried out at the University of Salford identified calcium channel blockers (CCBs) as …
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Repositioning fusidic acid for tuberculosis: semi-synthesis of analogues and impact of mycobacterial biotransformation on antibiotic activity
… chemotherapy predicated on a combination of four drugs. The increase in multiple forms of drug-resistant TB is a major cause for concern, underpinning the importance of a continuous pipeline of new anti-TB agents. Drug repositioning - that is, the optimization of existing drugs for new therapeutic …
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A Systems Biology Approach to Microbiology and Cancer
… The novel feature of this study is systematic drug repositioning for the prevention, control and treatment of TB using the Connectivity map. - Mathematical modeling: Polynomial dynamical systems, a state- and time- discrete logical modeling framework, is used to model two biological processes. …
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Repositioning of astemizole for malaria
… to the unfortunate spread of resistance to most drugs that were once effective and safe, including Artemisinins which form the basis of the current first-line regimen in the treatment of malaria. For this reason, it is crucial to invest research efforts using various approaches in the drug …
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Data mining techniques for large-scale gene expression analysis
… basis for optimal therapy selection and drug repositioning for a variety of diseases.
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Functional miRNA-based Phenotypic Screening as a tool to delineate HIV-host interactions and facilitate Novel Drug Discovery
… the utility of miRNA-based HCS for novel-drug discovery and drug repositioning.
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Piperazine-based pyrido[1,2-a]benzimidazoles: synthesis and pharmacological evaluation as potential antimalarial and antischistosomal agents
… parasites resistant to first-line antimalarial drugs comprising artemisinin combination therapies (ACTs) threaten malaria control. There is therefore a need to develop novel and chemically diverse alternatives that are safe, efficacious, and able to circumvent drug resistance. Schistosomiasis is …
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Synthesis, pharmacological and physicochemical profiling of antimalarial and antischistosomal N-aryl 3-trifluoromethyl pyrido [1,2-α] benzimidazoles
… have been committed to a limited arsenal of drugs that are threatened by resistance. This scenario, therefore, calls for decisive steps being taken towards the discovery and development of novel drugs with the ability to target multiple parasite stages and be efficacious against resistant …
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Un approccio di Biologia dei Sistemi per la modellazione di malattie ed il riposizionamento dei farmaci
Fornire strumenti facili da usare per supportare la ricerca clinica e biologica nell'analisi di fenomeni biologici complessi sta diventando una questione critica e una grande sfida. La biologia dei sistemi sta giocando un ruolo centrale in questa direzione. Questo tipo di approccio può essere …