Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"drug release mechanism"”.
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Investigation into reliability and performance of an implantable closed-loop insulin delivery device
… future device designs. To study insulin delivery mechanism and kinetics from the device, fluorescently labelled human insulin (FITC-insulin) was synthesised and characterised using RP-HPLC and MS, to produce a product with predominantly di-labelled conjugate (>75%) with no unreacted FITC or native …
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Novel Application of Twin Screw Extruder on Production of Diverse Formulations
… process. Nanocrystal formulations are promising drug delivery systems owing to their ability to enhance the bioavailability and maintain the stability of poorly water-soluble drugs. However, conventional methods of preparing nanocrystal formulations, such as spray drying and freeze-drying, have …
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Development of the Sustained Release Analgesic Formulations for Rodents and a Novel In Vitro Model for Parenteral Formulations with the Character of a Level A IVIVC
… is required. However, no sustained-release analgesic product for rodents was available when we started the project in 2008. Therefore, in order to reduce the stress of frequent handling and injection as well as improve the well-being of research animals, the first objective of this …
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A Novel Shear Thinning and Thixotropic Plga Micro Particulate Suspension System for Controlled Drug Delivery
… polymer of choice for many parenteral controlled drug release applications. This is mainly due to the inherent advantages of this polymer i.e. biodegradability, biocompatibility and non-toxic nature. The polymer, however, has a characteristic degradation pattern whereby the final erosion phase …
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Development of Co-processed Plasticized Cellulose Acetate for Sustained Release Matrix Tablets
… CA, it is a good polymer candidate for sustained release matrix tablets. Sustained release matrix tablets of cellulose acetate can be prepared by direct compression or wet granulation methods. However, previous studies showed that a large amount of CA was required to achieve the desired sustained …