Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 382 for “"drug release"”.
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Thermo-activated drug release.
Inhalation is an effective means of drug administration for treatment of respiratory diseases. Development of a respirable, stimuli-responsive aerosol formulation would further enhance the drug delivery efficiency. In this thesis, it is postulated that a magnetite/lipid formulation stimulated by …
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Metal Mediated Mechanisms of Drug Release
… reactions, and their applications in targeted drug delivery (Figure 1). The first project relates to the development of a palladium mediated bond-cleavage or “decaging” reaction which can cause a propargyl carbamate to decompose and release an amine. This was further developed by the …
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DRUG RELEASE FROM LIQUID FILLED CAPSULE FORMULATIONS
… of polyvinyl acetate (PVA) concentration, drug load, molecular weight of polyethylene glycol (PEG) and pH of the dissolution medium on the in vitro release of theophylline and ibuprofen from mixtures of PEG with 0 - 10 % w/w PVA, liquid-filled into hard gelatin capsules, have been studied. …
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Controlled drug release from oriented biodegradable polymers
… orientation as a novel method for controlling drug release from biodegradable polymers. The effect of various degrees of polymer orientation was studied in oriented Poly (L-lactic acid) (PLA) films containing curcumin and theophylline as model drugs. Additionally, direction specific drug …
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Remote controlled drug release in drug-eluting stents
… the most successful coronary intervention, drug-eluting stents are placed within obstructive arteries to restore blood flow to the heart and reverse life-threatening consequences. However, it is still plagued by the resurrection of artery occlusion, resulted by stent-induced restenosis.This …
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Elucidation of Drug Release Mechanisms in PLGA Microspheres
… and theoretically elucidate mechanisms of drug release in PLGA microspheres. We showed the effect of microsphere size and presence of an antacid on the stability and release of plasmid DNA from PLGA microspheres. We demonstrated that the use of Mg(OH)2 as a stabilizing excipient affected …
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Novel strategies for optimising drug release from medicinal implants
… a neointima, which renarrows the artery lumen. Drug-eluting stents (DES) release drugs to inhibit SMC proliferation and have been very successful in reducing ISR rates. However, they are not suitable for every patient group and lesion type, and may induce delayed healing of the endothelium, …
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Development of an ocular drug release system for cattle
… the device, (3) an in vitro study to obtain the drug release profiles of the insert, and (4) a study to compare the use of rings and a field treatment method using infected cattle;The device remained in the eyes an average of 3.92 days, with the retention time ranging from 1 day to 6 days;The …
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The Stability and Drug Release Characteristics of Multiple Emulsions
… an osmotic gradient will be relevant to the release of drugs from multiple emulsions.
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Drug release from pellets and matrices based on cellulose ethers.
… and ethylcellulose aqueous dispersion (Surelease), alone or m combination with each other, to control the release of metoclopramide hydrochloride or diclofenac sodium from coated pellets or matrices. The glass transitions of the polymeric films were determined by thermomechanical analysis …
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Macromolecular drug release from porous implants : sources of matrix tortuosity
Thesis (Sc.D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1984.
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Bioengineering functional polymer systems for glycan-based targeting and drug release
Bioengineering drug delivery facilitates re-potentiation of existing drugs and drug candidates, bypassing hurdles in novel drug development and accelerating the advance of medicine. Drug delivery strategies aim to enhance therapeutic effect by enhancing delivery to the target cells or tissues, …
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Theoretical prediction of drug release in GI tract from spherical matrix systems
The significance of controlled release drug delivery systems (CRDDS) lies in their ability to deliver the drug at a steady rate thus reducing the dosage interval and providing a prolonged pharmacodynamic effect. But despite the steadily increasing practical importance of these devices, little is …
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A study of polyethylene oxide-polysiloxane networks as biomaterials for drug release
Thesis (Ph. D.)--Massachusetts Institute of Technology, Harvard-MIT Division of Health Sciences and Technology Program in Medical Engineering and Medical Physics, 1989.
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Design of an intraperitoneal drug-release device for advanced ovarian cancer therapy
… over IV therapy alone. Large-volume infusions, drug-associated toxicity, and catheter-associated complications, however, increase morbidity and limit patient adherence, often resulting in discontinuation of IP therapy. The technical skill required for catheter implantation and IP chemotherapy …
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Effect of Laser Induced Crystallinity Modification on Degradation and Drug Release of Biodegradable Polymer
… as poly(L-lactic acid) (PLLA) are promising in drug delivery applications. In biodegradable polymer-based drug delivery systems, drugs are released at a rate determined by polymer degradation. Polymer degradation exhibits an undesirable induction period, during which a limited amount of embedded …
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The Role of Phase Inversion in the Drug Release Kinetics of Injectable Polymer Solutions
… induced phase inversion plays in the protein release kinetics of injectable drug delivery devices are presented. In situ optical techniques coupled with scanning electron microscopy (SEM) and high performance liquid chromatography (HPLC) were used to examine the relationship between the phase …
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Chitosan-Cellulose Nanocrystal Polyelectrolyte Complex Particles: Preparation, Characterization, and In Vitro Drug Release Properties
… surface, have potential applications in oral drug delivery. The purpose of this research was to develop an understanding of the formation and properties of chitosan–cellulose nanocrystal PECs and determine their in vitro drug release properties, using caffeine and ibuprofen as model drugs. …
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