Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"drug penetration"”.
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Analysis of anti-cancer drug penetration through multicell layers in vitro. The development and evaluation of an in vitro model for assessing the impact of convective fluid flow on drug penetration through avascular cancer tissues.
… (IFP) in tumours is recognized as a barrier to drug delivery resulting in reduced efficacy. High IFP impedes the normal process of convective fluid flow (CFF) from blood vessels into the interstitium. The aim of this study was to develop an in vitro model that could be used to measure CFF and to …
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Mechanical loading impacts intramuscular drug transport : impact on local drug delivery
Controlled-release drug-delivery systems enable efficient and defined administration of therapeutic agents to target tissues. However, ultimate drug distribution and pharmacologic effect are determined by target tissue pharmacokinetics. In muscular tissues, complex architecture that is further …
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Advances in targeted chemotherapy using MRI-guided focused ultrasound to disrupt the blood-brain barrier
… MRI-guided focused ultrasound for trans bbb drug delivery applications. This thesis demonstrates that MRI-guided focused ultrasound can be used to achieve consistent and reproducible BBB disruption without invasive craniotomy in rats, to enable doxorubicin to accumulate in normal brain at …
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Three-dimensional Hyaluronan-based Hydrogels Designed for Breast Cancer Spheroid Formation
… extract without HA. Breast CS expressed multidrug resistance protein 1, a drug efflux transporter on bifunctional HA hydrogels, and showed decreased doxorubicin drug penetration. Secondly, HA-oxime hydrogels were designed with tunable gelation to encapsulate breast cancer cells. We compared …
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Effect of Lactoferrin to Increase Drug Permeability of Primary Pulmonary Mycobacterial Granulomas
… and serves as a physical boundary to limit penetration of drugs during therapeutic treatment. In order to demystify the complicated relationship between the host and pathogen, many studies have been performed around the primary <em>Mtb</em>-induced granuloma to combat the challenges that …
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Modeling HIV-1 Infection in the Brain: The Effect of the Blood-Brain Barrier
… concern among HIV infected patients. As many ART drugs may fail to penetrate the blood-brain barrier (BBB), the long-term presence of viral RNA in the brain is considered to be associated with these disorders, such as early-onset dementia. \textit{In vivo} study of HIV infection in the brain is …
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Cavitation monitoring and spatial mapping for pulsed high-intensity focused ultrasound enhanced drug delivery
… the tissue at the focus. Ultrasound-enhanced drug delivery is an active and promising area of research. Enhanced drug diffusion and vascular permeability following HIFU is largely attributed to mechanical tissue disruption caused by ultrasound-induced bubble activity- cavitation. Although …
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Aerosolizable Drug-Loaded SPIONs for Treatment and Diagnosis of Pulmonary Tuberculosis
… infectious diseases, with the rise of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains presenting significant challenges to current therapeutic strategies. Existing treatment regimens are prolonged, systemically toxic, and poorly targeted, often resulting in poor …
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Development of Nanomedicine to Simultaneously Target Pancreatic Cancer Cells and Stroma
… a barrier that impedes the delivery of antitumor drugs into the tumor microenvironment and reduces the therapeutic efficacy. The objective of this dissertation is to develop combination therapies for pancreatic cancer by simultaneously targeting pancreatic cancer cells and the stroma. In Chapter …
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Investigating permeation of anti-mycobacterial agents in Mycobacterium tuberculosis and M. tuberculosis-infected macrophages in vitro as a model for early stage tuberculosis drug discovery
… public health. The increasing emergence of multi-drug resistance to current anti-TB drugs, exacerbated by the long treatment duration, highlights the need for new effective treatments or strategies to shorten the treatment duration, improve patient adherence and curb the alarming rates of …
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Addressing challenges in the treatment of tuberculosis and tuberculosis meningitis: a pharmacometric approach
… in treatment failure or the development of drug resistance. Secondly, TB management in hospitalised patients becomes more difficult since they often face more advanced stages of the infection, as well as physiological changes that could impact the pharmacokinetics of anti-TB drugs. Lastly, …
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Factors Influencing Topotecan CNS Penetration in Mouse Models
… Bcrp1 and P-gp in determination of topotecan CNS penetration in mouse models by using cerebral microdialysis. Microdialysis sampling of drugs in ventricular cerebrospinal fluid (vCSF) provides insight into drug penetration into the brain across the blood CSF barrier (BCB); however, this method has …
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Drug Delivery and Anti-Vascular Effects of Temperature Sensitive Liposomal Doxorubicin
… to decrease normal tissue toxicity by improving drug specificity to tumor. Relying on the EPR effect (Enhanced Permeability and Retention), a host of nanoparticles (from micelles and dendrimers to liposomes and lipidic nanoparticles) have been developed and tested for passive accumulation into …
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CNS Penetration of Tyrosine Kinase Inhibitors in Mouse Models
… barriers restrict the passage of anti-cancer drugs into the brain via several protective mechanisms.</p> <p>In the present study, we used cerebral microdialysis sampling, a technique for sampling unbound molecules in brain extracellular fluid (ECF) via semi-permeable probe, to assess the role …
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Development and Evaluation of a Niosome Carrier for Topical Use of Antioxidant
… if the antioxidant is incorporated into a lipid drug carrier to facilitate its transport across the skin and protect it from degradation. The carriers that are made up of non-ionic surfactants, having the similar bilayer structure to liposomes are niosomes. Theses carriers are widely used …