Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"drug mode-of-action"”.
-
Deconvoluting drug mode-of-action : transcriptomic evaluation of novel clinical lead antimalarials
… necessitates the discovery and development of effective antimalarials that target both the proliferative asexual parasite stages and the sexual asymptomatic stages that facilitate transmission to a new host. Furthermore, the immense replicative rate and thus mutational capacity of Plasmodium …
-
Application and Evaluation of a Chemical Modification- and Mass Spectrometry-Based Thermodynamic Assay for the Study of Protein-Ligand Interactions in Complex Mixtures
<p>While a number of different proteomic, genomic, and computational approaches exist for the characterization of drug action, each of the experimental approaches developed to date has both strengths and weaknesses. Currently, there is no one "perfect" assay for drug mode-of-action studies. A …
-
Investigating small-molecule inhibitors of platelet aggregation
… infarction, remains the number one cause of worldwide morbidity and mortality. The major cause of myocardial infarction is arterial thrombosis, driven by platelet aggregation. Adenosine diphosphate (ADP)-induced platelet aggregation is mediated by the Gi-protein-coupled receptor (GPCR), …