Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"drug mechanism"”.
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QUANTITATIVE PROTEOMIC APPROACHES TO STUDY DRUG MECHANISM OF ACTION
… is usually obtained by introducing in these drugs an electrophilic warhead able to bind specific nucleophilic sites in the protein target. Covalent inhibition of oncogenic protein kinases allows to obtain a stronger and prolonged therapeutic effect compared to reversible inhibition; however, …
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Using biological and chemical information to improve understanding of drug mechanism of action on the systems-level
The understanding of a therapeutic compound’s mechanism of action (MoA) can provide great benefits to the drug discovery process. Biological and chemical information e.g., transcriptomics data is increasingly becoming easier to measure by high throughput methods, and large amounts of this type of …
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Functional genetics reveals surprises about the mechanisms of action of chemotherapeutics
… benefit, another primary consideration of drug use was based on combinations of drugs with non-overlapping toxicity; that way patients could withstand more chemotherapy without succumbing to the side effects. Additionally, new drugs were developed with an eye largely toward reducing …
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Functional ionic liquids for use in pharmaceutical applications
… (APIs) that can be approved by the Federal Drug Administration (FDA) as neutral compounds, salts, or solvates of said neutral compounds and salts. Yet, the solid crystalline form can have unexpected and unfavorable effects on properties such as solubility, bioavailability, efficacy, etc., …
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To Develop a Small Interfering RNA (siRNA) Design and Information Resource to Facilitate Genetic Manipulaton of Human Cells
… patients, whose tumors do not respond to one drug, would respond to another. Thus, it would be very useful if one could rationally select the appropriate chemotherapy for each patient's tumor. We are asking is whether tumor gene "expression signatures" detected by microarray analysis could …
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Investigating small-molecule inhibitors of platelet aggregation
… thrombotic events. However, current antiplatelet drugs have several drawbacks such as the increased risk of bleeding, difficulty in fine-tuning the antiplatelet effects of irreversible antagonists, and variability in patient response. Furthermore, the nucleoside-based, reversible drug ticagrelor …