Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"drug library"”.
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Design of a Pragmatic Test Lab for Evaluating and Testing Wireless Medical Devices for Deployment on an Integrated IT Wireless Network
… test results to the EMR or remotely updating the drug library on numerous IV pumps. Each wireless application has varying demands on the connectivity infrastructure and will share radio frequency (RF) spectrum resources with a host of other non-medical device applications such as wireless phones, …
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Investigating FDA-Approved Drugs for Treatment of Multidrug-Resistant Neisseria gonorrhoeae
… Control and Prevention (CDC) have listed multi-drug resistant N. gonorrhoeae as an urgent threat that promptly requires the development of novel therapeutic agents. Traditional drug discovery and development is a time-consuming and costly process associated with high risks. To address the dire …
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In vivo identification of drug therapeutics for nemaline myopathy
… study employs the DiscoveryProbeTM FDA-approved drug library to perform a small molecule high-throughput drug screen as a strategy for developing therapies for Nemaline Myopathy (NM). Nemaline myopathy is a rare congenital neuromuscular disorder characterized by muscle weakness and the …
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Molecular Mechanisms in Amyloid Disorders. Novel Treatment Options in Hereditary Cystatin C Amyloid Angiopathy.
… used to test 12 monoclonal antibodies and 1040 drugs in a clinical drug library for their capacity to reduce cystatin C dimer formation in vitro. Several candidates for treatment of HCCAA could be identified. In a different set of patients, scheduled for elective surgery, the plasma levels of …
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Therapeutic targeting of DGKA-mediated macropinocytosis in lymphangioleiomyomatosis
… compound screen utilizing a repurposing drug library. We identified that ritanserin, a diacylglycerol kinase alpha (DGKA) inhibitor, synergizes with Chloroquine (CQ) to selectively inhibit proliferation of TSC2-deficient mouse embryonic fibroblasts (MEFs) compared to TSC2+/+ MEFs. …
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Zebrafish as a Model for Studying Estrogen Signaling and Estrogenic Endocrine Disruption
… screening of ToxCastTM Phase I pesticides library and NIH Clinical Collection drug library was performed using Tg(5xERE:GFP) reporter fish. A total of 26 environmental estrogens and 62 clinical drugs with estrogenic activities were identified from these two libraries. Then environmental …
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Drug repurposing against the store-operated calcium entry (SOCE) pathway and subsequent exploration of SOCE in oligodendrocyte progenitor cells
… conditions. In this study, the FDA-approved drug library was screened for agents that share significant similarity in 3D shape and surface electrostatics with few, hitherto best-known inhibitors of SOCE. This has led to the identification of five drugs that showed dose- dependent inhibition …
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Development of novel receptor tyrosine kinase inhibitors by a chemocentric approach
… target. This is referred to as target-based drug discovery. It was hoped that adopting this approach would usher in a new golden age of drug discovery. However, this has not been the case, with issues arising such as the target’s mechanism of action being poorly understood, with it not …
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Metabolomics and chemical library screening for antibacterial drug discovery
… This method can also be used to study effects of drugs on biosynthesis of DNA and can help in understanding the cellular biochemistry when organisms, such as bacteria are exposed to exogenous molecules interfering with DNA biosynthesis machinery. Part II of this dissertation describes the …
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Library Screening and Focused Multiomics of Antibacterial Action on Vancomycin-Resistant Enterococci faecium
… developing a two-dimensional chemical compound library screening strategy. The first screening was done using an FDA approved drug library that was screened against vancomycin-resistant Enterococcus faecium (VREfm) in both its original (unmetabolized; UM) and its microsome metabolized …
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Novel treatment strategy for ALK-positive Anaplastic Large Cell Lymphoma
… would be the introduction of a second targeted drug that has a different mechanism of action to be used in combination with ALK TKIs, which may potentiate these effects and could improve clinical outcomes. To identify alternative drug targets for ALK-positive ALCL in particular, those that may, …
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Identifying novel drugs for the treatment of rhabdomyosarcoma
… The aim of this study was to identify novel drugs for the treatment of the two major RMS subtypes viz alveolar (ARMS) and embryonal (ERMS) RMS and to do so it adopted a two-pronged approach. Firstly, a novel binuclear palladacycle, AJ-5, was investigated for its anti-cancer activity and its …
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Studying the Transcriptional and Epigenetic Perturbations of Haematopathologies Expressing NPM1-ALK
… NSCLC, and ALK-driven NB, a large-scale drug library comprising of approximately 300 clinically approved drugs and novel agents targeting transcriptional and epigenetic mediators was applied to several in vitro models. Such models included cell lines representing ALK-driven malignancies …