Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"drug efflux transporter"”.
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Three-dimensional Hyaluronan-based Hydrogels Designed for Breast Cancer Spheroid Formation
… extract without HA. Breast CS expressed multidrug resistance protein 1, a drug efflux transporter on bifunctional HA hydrogels, and showed decreased doxorubicin drug penetration. Secondly, HA-oxime hydrogels were designed with tunable gelation to encapsulate breast cancer cells. We compared …
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Advancing Precision Medicine in Psychiatry: Genetic Insights into Antidepressant Treatment Outcomes
… in pharmacokinetic genes such as CYP2C19 (drug metabolizing enzyme) and ABCB1 (encoding the drug-efflux transporter P-glycoprotein), and broader polygenic liability may partly explain this variability. Recent advances in psychiatric genomics have enabled the use of polygenic risk scores …
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Combating HIV-1 by Targeting Drug Efflux Transporters on the Macrophage Reservoir
… reside and replicate even under antiretroviral drug therapy (ART). Infected macrophages, which represent a long-term viral reservoir have been shown to lead to viral rebound independently. In response to the environmental stimuli, macrophages can be polarized into different phenotypes: the …