Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 82 for “"drug effects"”.
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The role of mitochondrial transporters in human physiology and adverse drug effects
… of human mitochondrial transporters in adverse drug effects, to overcome the technical challenges in their functional characterisation and to identify compounds that can inhibit substrate transport. So far, most drug interactions have been reported for the mitochondrial ADP/ATP carrier (AAC), …
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Associating adverse drug effects with protein targets by integrating adverse event, in vitro bioactivity, and pharmacokinetic data
Adverse drug effects are unintended and undesirable effects of medicines, causing attrition of molecules in drug development and harm to patients. To anticipate potential adverse effects early, drug candidates are commonly screened for pharmacological activity against a panel of protein targets. …
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Single-cell transcriptomics identifies key components in metabolic pathways of drug perturbed activated CD4+ T cells
… memory human CD4+ T cells. I proceed to describe drug effects on CD4+ T cell day 3 proliferation and gene expression by single cell transcriptional profiling at resting state, 16 hours and 3 days after stimulation with aCD3/aCD28. My observations reveal cell subpopulations present only at certain …
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The reduction of tolerance to the anticonvulsant effects of antiepileptic drugs
… has been shown to develop to the anticonvulsant effects of many different antiepileptic drugs. In some cases, tolerance to antiepileptic drug effects is so complete that the drugs become clinically ineffective, even at toxic doses. This is clearly problematic for the treatment of epilepsy. The …
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Predicting drug interactions with a three level causal model
… system is described. TLCM traces causal paths of drug action through up to three levels of drug action. The three levels which are molecular/receptor level, physiological level and clinical level provide both deep and shallow reasoning in order to overcome the problem of unknowns in medical expert …
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The Discriminative Stimulus Properties of the Atypical Antipsychotic Clozapine in C57BL/6 Mice
… may contribute to atypical antipsychotic drug effects. Clozapine (2.5 mg/kg) drug discrimination in C57BL/6 mice may selectively screen atypical antipsychotic drugs. Previous data show that the atypical antipsychotics olanzapine, risperidone, ziprasidone but not the typical antipsychotic …
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Cultural differences on placebo effects elicited by pharmaceutical ads
Placebo and nocebo effects have been a widely concerning issue, as they describe the psychological factors influencing medication outcomes. Previous research mostly focused on how placebo and nocebo effects occur, offering explanations for their mechanisms. Individual differences, especially at the …
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Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum
… actin disrupting and PI (3) kinase inhibiting drug effects on haemoglobin endocytosis and transport vesicle trafficking within the malaria parasite Plasmodium falciparum.
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Prenatal Cocaine Exposure and Cardiac Programming
… but mechanisms underlying the detrimental effects of cocaine on the developing heart are not fully understood. The central hypothesis is that cocaine exposure during fetal development may cause <em>in utero</em> programming of apoptotic pathways, which may has lasting and prolong effect on …
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The Social Economy of Buying, Selling, Trading, and Consuming Drugs: A Comparison of Individual and Sub Cultural Strategies Among Methamphetamine Users and Dealers in Two Cities
… and collective meanings and functions of drug taking for research subjects including methamphetamine users and dealers in drug subcultural groups recruited in two major cities. Participant observation was conducted in the two cities among methamphetamine users and dealers. In depth …
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Elucidation of pharmacologically manipulated responding in the delay discounting task in high alcohol preferring mice
… the AA or ID method for 15 days to evaluate drug effects on impulsive behavior. <em>Results:</em> Stimulant administration resulted in a reduction of impulsivity in the AA group, but had no effect in the ID group. There was no effect on impulsivity of EtOH administration in AA or ID groups. …
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Drug prescribing and administration changes in hospitalized geriatric patients : analysis of three drug utilization review programs
… patients or 0.5% of the population. The use of drugs in this population comprises approximately 25% of the prescription drug market in the United States which is directly related to the greater occurrence of pathological problems associated with the aging process. While it is evident that the …
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Validating the therapy prediction model through a breakdown analysis on ICU patient medical records
… we developed a model for predicting therapy effects in heart disease using signal flow analysis that describes constraint relations among physiological parameters. In order to accurately describe and predict the therapy effects on a patient in heart failure, the model needs to be tested and …
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Discriminative Stimulus Effects of Gabapentin
… sought to evaluate the discriminative stimulus effects of the anticonvulsant gabapentin in rats trained to discriminate 30.0 mg/kg gabapentin from vehicle in a two-lever drug discrimination task. All of the ten rats tested were able to establish gabapentin as an interoceptive cue. Gabapentin …
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Behavioral assessment of the time course and relative intensity of acute lithium chloride toxicosis in adult and weanling rats
… of and developmental differences in the toxic effects of a single i.p. injection of LiCl. The studies examined LiCl' s effect on food reinforced bar pressing, open-field behavior, water intake, and taste aversion learning. Both experiments used a 2 x 3 x 21 mixed design which provided for the …
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Covalent Binding and other Mechanisms of Primaquine Toxicity
<p>A dose-dependent covalent binding of primaquine to mouse liver microsomal protein was found in both in vitro and in vivo studies. The binding in vitro was linear during the first 90 minutes of incubation and dependent on the concentration of mouse liver microsomal protein. The in vitro covalent …
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The renal effects of nonsteroidal anti-inflammatory drugs (NSAIDS) in dogs with chronic kidney disease (CKD)
… becomes critical to offset the vasoconstrictive effects of norephinephrine, angiotensin II, and vasopressin. Nonsteroidal anti-inflammatory drugs (NSAIDs) produce both their beneficial and detrimental effects through inhibition of the cyclooxygenase enzyme and subsequent interference with …
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Selective memory impairments produced by transient lidocaine-induced lesions of the nucleus accumbens
… prior win-shift experience. State-dependent drug effects were ruled out by replicating the disruptive effects of lidocaine-infusions into the N.Acc. on spatial win-shift performance in animals receiving this treatment prior to both training and test phases. Collectively, these results …
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Gabapentin Discriminative Stimulus Effects
<p>Gabapentin (Neurontin®), an anticonvulsant drug, is primarily prescribed for neuropathic pain and epileptic seizures. Gabapentin is an inhibitor of the voltage gated calcium channel (VGCC) subunit α<sub>2</sub>δ-1. Due to its unique binding site, gabapentin is widely thought to have low abuse …
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