Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"drug disposition"”.
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Equilibrative Nucleoside Transporter Mediated Drug Disposition Across the Blood-Testis Barrier
… barrier poses a problem for therapeutic disposition to the male genital tract, which may allow viruses or cancer to persist in the testis, and impedes the development of male contraceptives and fertility treatments. Drug transporters present at the basal and apical membranes of testicular …
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The use of MALDI-MS for imaging drug disposition in respiratory disease models.
… of standards for use in the quantification of drugs in tissue sections.MALDI-MSI has been used to acquire data from serial sections obtained at equal intervals through control mouse lung tissue, homogenate registration markers were incorporated in order to aid the final 3D image construction. …
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Role of Membrane Transporters in Drug Delivery, Drug Disposition And Drug-Drug Interactions
… membrane transporters which play a vital role in drug absorption, distribution, metabolism and excretion. Understanding of functionality and molecular expression of drug transporters can prove to be of utmost importance in drug delivery or drug design by targeting specific transporter proteins. …
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Drug Metabolizing Enzyme, Drug Transporter Expression And Drug Disposition Are Altered In Models Of Inflammatory Liver Disease
… is based on the idea that too much of a drug will cause toxicity, while too little will result in failure to elicit the desired response. A major factor in the ability of a patient to handle any dose of a drug is the capacity to metabolize and eliminate that drug from the body. For the …
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Investigation of ocular drug metabolism and pharmacokinetics using multi-omics and in-situ microdialysis
Ocular drug disposition is governed by a complex interplay of anatomical barriers, local metabolic activity, transporter expression, and tissue-specific physiological processes. However, quantitative understanding of drug-metabolizing enzymes and transporters in ocular tissues remains limited, …
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Age-Associated Expression Patterns of OATP 1B1 and OATP 1B3 and Their Effect on the Disposition of Fexofenadine
As part of the drug disposition process (absorption, distribution, metabolism, excretion), an often overlooked aspect is transport. In order for drugs to be metabolized and excreted from the body they go through the liver or other drug removal organs. For drugs that are polar or are large they must …
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Applications of Physiologically Based Pharmacokinetic Models in Veterinary Medicine.
… are unable to predict possible adverse drug reactions due to drug interactions. As combination drug therapy is rapidly increasing, so too does the chance for an adverse drug reaction due to drug interactions. There is a need within veterinary medicine for more predictive and flexible …
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Gut microbiota-mediated bile acid metabolism: implications for oral drug absorption
… pharmacokinetic variability. As newly emerging drug candidates trend toward low solubility and/or permeability, biopharmaceutical properties that prolong gastrointestinal residence time, and thereby microbial contact, identifying and manipulating the microbial processes influencing drug …
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To Investigate The Impact Of Gut Bacteria On Efflux Transporter Expression And Function In Gastrointestinal Mucosae
… and contribute to individual variations in drug therapy. Therefore, understanding molecular links between the gut microbiome and oral drug disposition is critical for realizing the goals of precision medicine. The purpose of the study was to characterize the function of P-glycoprotein (P-gp) …
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Renal Drug Transporters – Clinical Significance and Role in Drug-Drug Interactions
Drug transporters play an important role in drug disposition and can be major determinants of drug pharmacokinetics, pharmacodynamics and toxicity. In contrast to drug metabolizing enzymes, which mainly concentrate in the liver and small intestine, drug transporters are expressed ubiquitously …
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Studies of the expression and characterization of various transport systems at RBE4 cells, an in vitro model of the blood-brain barrier
… to provide a basis for strategies to regulate drug disposition into the brain. Immortalized rat brain endothelial cells (RBE4 cells) have been used in this study as an in vitro model of the BBB. The present study has shown that the RBE4 cells are a suitable model of the BBB for transporter …
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Regulation of Hepatic Drug Transporters Expression in Mice During Acute Inflammation
… of several hepatic ABC and SLC transporters and drug-metabolizing enzymes. These pronounced changes in hepatic transporters contribute to altered drug disposition; therefore, understanding the molecular mechanisms would aid in identifying potential sources of drug variability in diseases …
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Establishing Decision Limits for Therapeutic Drugs Detected in Animals Exhibited at Livestock Shows
… in the livestock show industry often involves drug testing. Detection of therapeutic drugs at very low concentrations in approved animal species raises questions about current anti-doping regulations in exhibition animals. Therefore, the purpose of this research was to identify and address data …
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Development of genotyping systems for pharmacogenomics profiling
Genetic variability in genes encoding drug metabolizing enzymes, transporters and targets are known to be the main factors of inter-individual differences in therapeutic outcome. Genetic factors are estimated to be responsible for about 15-30% of inter-individual variation in drug disposition and …
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Effect of penicillin G on the reproduction of Salmonella cholerasuis in the presence and absence of porcine alveolar macrophages in a pharmacodynamic model
… the influence of host defenses, the dynamics of drug disposition, or the interaction between changing drug concentrations and a bacterium in a host environment. The purpose of this research project was to modify an in vitro model for examining the effects of changing penicillin G concentrations …
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IN-VITRO PK/PD PROFILING AND MODELING OF THE ANTI-SICKLING AGENTS, 5-HYDROXYMETHYL FURFURAL (5-HMF) AND NOVEL SYNTHETIC ALLOSTERIC EFFECTORS OF HEMOGLOBIN (AEH) IN HUMAN WHOLE BLOOD
… Time- and concentration-dependent in-vitro disposition of 5-HMF in human whole blood was fully characterized and quantitatively modeled. In-vitro time- and concentration-dependent pharmacodynamic (PD) profiling of AEH (0.5 – 5 mM) was carried out in normal whole blood. 5-HMF binding to …
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Hybrid modeling techniques to support drug-development and post-market analysis of anti-infectives
… predictive platforms in any discipline. In drug development and global health fields, massive use of in silico tools deals with the anticipation of plausible scenarios, which overall inform on best therapeutic options. The thesis exemplifies this model-based contribution by addressing two …
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Structural and functional investigation of the organic anion transporting polypeptide 1B1 (OATP1B1)
… salts, thyroid hormones, statins and anti-cancer drugs. Therefore this protein family play an important role in cell homeostasis and drug disposition, and are implicated in disease and drug-drug interactions. However there is little information available regarding the structural properties of …
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