Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"drug discrimination"”.
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Gabapentin Discriminative Stimulus Effects
<p>Gabapentin (Neurontin®), an anticonvulsant drug, is primarily prescribed for neuropathic pain and epileptic seizures. Gabapentin is an inhibitor of the voltage gated calcium channel (VGCC) subunit α<sub>2</sub>δ-1. Due to its unique binding site, gabapentin is widely thought to have low abuse …
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In vivo and in vitro aspects of imidazoline-2(1/2)sites within the central nervous system
… binding site were probed using the technique of drug discrimination and receptor autoradiography. Data presented in this thesis indicates the I2 ligand 2-BFI generates a cue in drug discrimination. Further studies indicated agmatine, a proposed endogenous imidazoline ligand, and a number of …
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Determinants of Abuse-Related Effects of Monoamine Releasers in Rats
… rats: intracranial self-stimulation (ICSS) and drug discrimination. First, this work confirmed and expanded upon previous findings that selectivity for promoting release of dopamine versus serotonin is one determinant of abuse-related effects produced by monoamine releasers. This was …
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The Discriminative Stimulus Properties of the Atypical Antipsychotic Clozapine in C57BL/6 Mice
… may contribute to atypical antipsychotic drug effects. Clozapine (2.5 mg/kg) drug discrimination in C57BL/6 mice may selectively screen atypical antipsychotic drugs. Previous data show that the atypical antipsychotics olanzapine, risperidone, ziprasidone but not the typical antipsychotic …
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Design, Synthesis, and Pharmacological Characterization of Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) Positive Allosteric Modulators
… health issues such as impulsivity disorders, drug addiction, depression, schizophrenia, and obesity. Therefore, restoration of the diminished signaling capacity through 5-HT2CR activation has therapeutic potential. A series of new molecules based on the 4-alkylpiperidine-2- carboxamide …
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Discriminative Stimulus Effects of Gabapentin
… mg/kg gabapentin from vehicle in a two-lever drug discrimination task. All of the ten rats tested were able to establish gabapentin as an interoceptive cue. Gabapentin produced full generalization (≥ 80% gabapentin-lever responding) for itself at 30.0, 60.0, and 120.0 mg/kg doses. …
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Discriminative stimulus properties of 3-substituent rimonabant analogs
… and produce antinociception and catalepsy. Drugs that produce this tetrad of effects within a limited dose range are likely to function as CB1 receptor agonists. A structure activity relationship study from our laboratory investigating analogs of the CB1 antagonist rimonabant revealed that …
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Characterisation of the role of peripheral μ-opioid receptors in the behavioural effects of heroin and their underlying neural systems in the rat
… of control. In Chapter 8, I demonstrate using a drug discrimination task that pΜOR antagonism enhances the discriminative properties of heroin as revealed by an increase in the response accuracy for the heroin-paired lever as compared to controls. This suggests that pMOR-dependent mechanisms and …
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CHARACTERIZING THE PHARMACOLOGICAL PROFILE OF MEPHEDRONE AND DETERMINING THE ABUSE LIABILITY MECHANISMS
Illicit drug use has been a growing concern over the past few decades. The rise in use of illegal drugs drove the government and law enforcement to aggressively tackle this problem and crackdown on the illicit use of drugs. However, this sparked a further interest in ‘legal highs.’ Before 2011, …
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Discriminative Stimulus Effects of Putative Antipsychotic Drugs
… stimulus properties of antipsychotic drugs, by establishing the typical antipsychotic drug chlorpromazine, and the atypical antipsychotic drug clozapine as discriminative stimulus in two different groups of rats. The rats trained to discriminate chlorpromazine from vehicle failed to do …