Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 667 for “"drug discovery"”.
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Halogenated Heterocycles for Drug Discovery
Within a number of industries, and particularly within the pharmaceutical industry, there is a desire for reliable, high yielding routes towards large numbers of valuable small molecules that allow a wide range of products to be synthesised. Heterocyclic compounds are particularly sought after as …
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Probabilistic methods for drug discovery
… and domain knowledge driven task such as drug discovery. We also derive a generative topographic mapping (GTM) based data visualisation approach which estimates feature saliency simultaneously with the training of a visualisation model.
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Process optimization in drug discovery
… I explore Novartis's process for developing drugs, specifically the earlier stages of research leading to high throughput screening. During the course of a 6.5 month, on-site project, Novartis's processes were identified, data were collected and relevant literature in product development and …
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Inventory management for drug discovery
This thesis documents a study carried out at the Novartis Institutes for BioMedical Research (NIBR) in Cambridge, MA. The study focused on the development of inventory management processes for laboratory consumables. The pharmaceutical R&D process is characterized by a dynamic project portfolio, …
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Antibiotic Drug Discovery Targeting Bacterial Metabolism
… mortality, and financial burden associated with drug resistant infections. The antimicrobial resistance crisis presents an urgent need for new antimicrobials with distinct mechanisms of action from existing drugs. The current pharmaceutical pipeline of new antibiotics is limited due to three …
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Accelerating antimalarial drug discovery through repositioning
… measures have been hampered by the emergence of drug resistance to most antimalarial therapies. Early signs of drug resistance to the current frontline option, the artemisinins, make it imperative that novel drug candidates are discovered. One possible short-term solution is drug repositioning, …
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Trpv5: Structure, Function And Drug Discovery
… studies including but not limited to rational drug design, molecular dynamics investigations and targeted biochemical probing.
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Natural product chemistry in drug discovery
… aspects of natural product research: the discovery and biological evaluation of plant-derived specialized metabolites as potential drug leads, and the verification of their botanical sources to ensure chemical and taxonomic accuracy. It comprises three publications. The first is a …
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Targeting isoprenoid biosynthesis for drug discovery
… threats to human beings. With the rapid rise in drug resistance, there is a need for new drugs, and isoprenoid biosynthesis is an attractive target for drug discovery. In chapter 1, I briefly introduce the isoprenoid biosynthesis pathway and two important drug targets: a trans-prenyl transferase …
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Graph Representation Learning for Drug Discovery
Drug discovery is an expensive and labor-intensive process, typically taking an average of 10–15 years. The goal of this thesis is to substantially accelerate this process by developing machine learning (ML) algorithms for three key steps in drug discovery pipeline. First, we develop better …
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OPENING NEW CHEMICAL SPACE IN DRUG DISCOVERY
Small molecules have always been of interest in chemistry and biology because of their ability to exert powerful effects on the functions of macromolecules comprising living systems. Screening collections or libraries of small molecules is the most common way to identify new chemical modulators of …
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Computer-Aided Drug Discovery for Helicobacter pylori
<p>Helicobacter pylori is a high-priority drug-resistant pathogen and is currently the only bacteria considered to be a class I carcinogen and there is a critical need to identify novel chemical matter to treat H. pylori infections. Hp is responsible for greater than 60% of gastric cancer related …
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Data-driven peptide drug discovery and design
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
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Machine learning for drug discovery and beyond
The student, Wei Qian, accepted the attached license on 2022-07-01 at 14:44.
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Drug discovery against malaria parasite: drug repositioning strategy
… year and there are ever present problems due to drug resistance. In this work, I used drug-repositioning strategy with bisphosphonates to discover a lead that is active against malaria in vivo. The developmental procedures include, in vitro high throughput screening, x-ray crystallography and …
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Machine learning for 3D small molecule drug discovery
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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Creating effective drug discovery methods in Mycobacterium abscessus
… efficacy is through continued development of new drugs capable of evading resistance mechanisms. However, over the past 30 years the antibiotic drug development space has been characterised by the withdrawal of recourses, large pharmaceutical companies, and funding. This is a result of a mismatch …
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Drug discovery at the site of pulmonary tuberculosis
… suggests the inadequacy of current first line TB drugs to eliminate the causative agent Mycobacterium tuberculosis (Mtb). Among multiple potential causes, this may be due to poor distribution of TB drugs into the pulmonary lesions in which the bacilli reside. In attempting to explore this …
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Antibody drug discovery: From Idea to Biotherapeutic Molecule
… Group (APEG) is responsible for early stage drug development of biotherapeutic molecules. Part of this responsibility is delivering high quality molecules while meeting tight deadlines. Across the industry there is constant pressure to decrease timelines, while at the same time the complexity …
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