Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 490 for “"drug development"”.
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Analytics for financing drug development
Financing drug development has a particular set of challenges including long development times, high chance of failure, significant market valuation uncertainty, and high costs of development. The earliest stages of translational research pose the greatest risks, which have been termed the "valley …
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The drug development process : evaluation of PDUFA I/II and investigation into reducing drug development times
… takes approximately eight years to bring a novel drug to market at an average cost of $800 million. Over the last ten years, the Food and Drug Administration (FDA) has helped to reduce the time from filing a new drug application (NDA) to granting marketing approval (i.e. the approval phase). …
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The globalization of clinical drug development
… clinical research of investigational drugs (also called clinical development) has traditionally been carried out in relatively developed countries in the North American, Western European, and Pacific regions. However, lately it has been widely reported that clinical trials starting now …
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Financial model of the drug development process
Thesis (S.M.M.O.T.)--Massachusetts Institute of Technology, Sloan School of Management, 1995.
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Project management and organization structure in drug development
Thesis (Ph. D.)--Massachusetts Institute of Technology, Sloan School of Management, 1995.
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Protein and Ligand Dynamics in Drug Development and Resistance
… therapeutics. In this work, we describe the development and implementation of novel techniques to study dynamics in proteins and protein-bound ligands, and discuss our investigation of the crucial role of dynamics in two disease-relevant systems.</p><p>First, we have expanded the utility of …
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Adaptive Designs and Methods for More Efficient Drug Development
The development of a novel drug is a time-consuming and expensive process. Innovative trial designs and optimal sequences of clinical trials aim to increase the efficiency of this process by improving flexibility and maximising the use of accumulated information throughout the trials while …
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Insights from biomolecular condensates into disease and drug development
… of the role of condensates in disease and drug development could facilitate similar paradigm shifts, with early evidence suggesting that condensate dysregulation may be a feature of many diseases, and that therapeutics can modulate condensates. In the studies presented in this thesis, we …
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Forecasting resource requirements for drug development long range planning
… and manufacturing capacity requirements for a drug development organization. A pharmaceutical drug development group is responsible for designing the manufacturing process for new potential drug products, testing the product quality, and supplying product for clinical trials. The drug …
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Engineering Liver and Cardiac Models for Drug Development and Regenerative Medicine
… data for preclinical evaluations of drug-induced liver injury and cardiotoxicity, speeding up the notoriously lengthy and inefficient drug development pipeline, as well as fundamental investigations into stem cell behavior and cell-cell interactions. Tissue engineering is also …
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Topical pharmacokinetics for a rational and effective topical drug development process
Topical drugs are not developed by the same process as oral drugs. The process is more uncertain and contains gaps. This leads to a poor discharge of risks before going to the clinical phases. The topical drug development process is reviewed in the introduction of the thesis. In particular, past …
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Altering the Regiospecificity of C6 Indole Prenyltransferase Enzymes Towards Drug Development
… us to utilize PTs as a unique approach towards drug development. PriB PT is an example of aromatic PTs that has been characterized previously as a L-tryptophan (L-Trp) C6 <em>C</em>-prenyltransferase (C6-<em>C</em>-PT). Analysis of PriB binding pocket, highlighted key residues that might play an …
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Portfolio valuation in early drug development : a systematic accounting of utility
Pharmaceutical drug development is exhibiting a consistent trend of increased R&D investment required per successful therapy brought to market. Simultaneously, cultural and political sentiment is increasingly putting downward pricing pressure on new therapies. In this difficult environment it is …
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Amplifying signals in the tumor microenvironment for drug development and diagnostics
… the pace of biological discovery leading to the development of targeted therapies and immunotherapies, which have resulted in unprecedented survival benefits for patients. Additionally, they have also materialized in how disease is diagnosed and monitored, which increasingly involves genomic …
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Assessing the impact of tumor evolution on oncology drug development and commercialization
… developing and commercializing targeted oncology drugs directed at a specific tumor mutation instead of all forms and mutations of a single target. While oncologic drugs targeted to aberrant or overexpressed pro-proliferative proteins have revolutionized cancer treatment, tumors treated for long …
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Targeting protein: protein interaction sites for drug development against voltage-gated sodium channels
… including psychological, neurological and developmental disorders. Unfortunately, currently available drugs targeting Nav channels are directed against highly conserved domains of the α-subunit of all Nav channels, and as such they have severe side effects, including cardiac malfunction. …
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The role of subgroups and sub-populations in drug development and drug regulation
… the role of subgroups and sub-populations in drug development and regulation and includes the critical appraisal of regulatory guidance.<br></br><br></br>Chapter One introduces clinical trial methodology and describes the current regulatory environment.<br></br><br></br>In Chapter Two, …
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