Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"drug conjugate"”.
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The Development of a Novel Peptide-Drug Conjugate for Treating Triple-Negative Breast Cancer
… like hormone therapies and targeted HER2 drugs are ineffective. The use of chemotherapies in treating TNBC is an effective option instead. However, chemotherapies are not selective, thus they cause severe side effects such as cardiotoxicity, myelosuppression, alopecia and gastrointestinal …
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The Development of a Cancer-Targeting Peptide-Drug Conjugate for the Treatment of Melanoma
… to over 2 years as a result of this concerted drug development effort; however, this rapid development of treatment technologies come with new severe adverse effects, as well as increased opportunity for toxicity and drug resistance. It is not uncommon for a treatment to switch before …
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Epiregulin as a Novel Target for Antibody-Drug Conjugate Development for the Treatment of Colorectal Cancer
<p>Antibody-drug conjugates (ADCs) are a fast-growing class of molecularly targeted therapies with 13 currently approved and over a 100 in clinical trials. ADCs consist of a monoclonal antibody (mAb) conjugated to a potent cytotoxic payload to selectively target tumor antigens highly expressed on …
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Characterizing ALCAM as an oncoprotein and immunotherapeutic target in neuroblastoma
… exploiting these findings with a novel antibody-drug conjugate platform to avoid on-target, off-tumor toxicities. We generated inducible ALCAM knockdown cell lines using CRISPR inhibition and profiled the effects on neuroblastoma growth and survival using live-cell monitoring assays, …
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Drug Delivery Strategies Using Light Sensitive Molecules
… chemotherapy. In chemotherapy, an anti-tumoral drug is used to treat the tumor either by killing or stalling the growth of the tumor cells. In certain types of cancer, for e.g. metastatic breast cancer, the first line of therapy is often chemotherapy. But the inability of current clinically …
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The development of functionalised stapled peptides as chemical tools to modulate biological processes in platelets and as novel antimicrobial therapeutics targeting Pseudomonas aeruginosa
… 2. The development of cleavable stapled peptide-drug conjugates to target Pseudomonas aeruginosa Antimicrobial resistance (AMR) is a major healthcare threat, and Gram-negative bacteria such as Pseudomonas aeruginosa pose a significant therapeutic challenge. Antimicrobial peptides disrupt …
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Bioengineering functional polymer systems for glycan-based targeting and drug release
Bioengineering drug delivery facilitates re-potentiation of existing drugs and drug candidates, bypassing hurdles in novel drug development and accelerating the advance of medicine. Drug delivery strategies aim to enhance therapeutic effect by enhancing delivery to the target cells or tissues, …
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Evaluation of Peptides and Peptide–Doxorubicin Conjugates Designed and Synthesized for Targeting Triple-Negative Breast Cancer via Cell-Surface Receptors
… This forms the foundation of ligand-targeted drug delivery. Among different breast cancers, treatment of the triple-negative breast cancer (TNBC) subtype has been particularly challenging, largely due to the absence of a well-defined biomarker to exploit for targeted drug delivery. This has …
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Design and applications of antibody mimics against epidermal growth factor receptor
… a number of monoclonal antibodies and their drug conjugates have been approved as therapeutic agents. While these molecules have great potential in various applications and therapeutics, extensive use of full length antibodies has been hampered by the high cost of production, large molecular …
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Rapid, Efficient and Versatile Strategies for Functionally Sophisticated Polymers and Nanoparticles: Degradable Polyphosphoesters and Anisotropic Distribution of Chemical Functionalities
… transformed into a multifunctional Paclitaxel drug conjugate by densely attaching the polyphosphoester block with azide-functionalized Paclitaxel by azide-alkyne Huisgen cycloaddition. This Paclitaxel drug conjugate provides a powerful platform for combinational cancer therapy and bioimaging …
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Novel sustained release formulation of leveodopa-dendrimer conjugate
… these disease symptoms. Levodopa is the current drug of choice for the treatment of PD. The effectiveness of any investigative PD drug is compared with that of levodopa. However, its dose needs to increase with chronic use and there are some side effects like nausea and vomiting are associated …
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Metal Mediated Mechanisms of Drug Release
… reactions, and their applications in targeted drug delivery (Figure 1). The first project relates to the development of a palladium mediated bond-cleavage or “decaging” reaction which can cause a propargyl carbamate to decompose and release an amine. This was further developed by the …
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Design of smart linkers and their applications in controlled-release drug delivery systems
Antibody drug conjugates (ADC) represents an interesting strategy in tumour targeted therapy . The approach is based on the combination of the high affinity of an antibody towards its antigen and the high cytotoxicity of a drug, leading to a selective therapuetic agent with improved efficacy and …
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Peptide-Based Platform For Cancer Therapeutics And Drug Transportation Across Blood-Brain Barrier
… inadequate availability to the tumor tissue, drug resistance, and the complicated microenvironment in tumor tissues. As a result, there is a great need to develop targeted delivery systems for chemotherapy agents for prostate cancer therapy. One objective of this dissertation is to develop …
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Metabolic vulnerability in HER2-positive Breast Cancer
… kinase inhibitor (lapatinib) and an antibody-drug conjugate (trastuzumab emtansine), have significantly prolonged the overall survival of HER2-positive breast cancer patients. However, almost all patients develop resistance either from the beginning of therapy or with prolonged treatment in …
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Synthesis and biological evaluation of auristatin-F recombinant antibody-drug conjugates for cancer therapy
… a contribution to the emerging field of antibody-drug conjugate (ADC) therapeutics, in which novel ADCs were generated and biologically evaluated for therapeutic potential and specificity towards cancer cells. SNAP-tag site-directed conjugation was employed in order to overcome the current …
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Targeting the actin cytoskeleton in HER2+ metastatic cancer cells using a macrolide toxin
… as a potential warhead for a novel antibody drug conjugate (ADC) to target highly metastatic HER2+ breast and ovarian cancers. We found that MycB treatment of HER2+ breast (SKBR3, MDA-MB-453) and ovarian (SKOV3) cancer cells led to loss of viability (IC50 values ≤ 64 nM). Sub-lethal doses of …
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Targeting the B-Cell Receptor in Diffuse Large B-Cell Lymphoma
… platforms. Next, I used the anti-CD79B antibody drug conjugate Polatuzumab-Vedotin (POLA-V) as a tool to study regulators of surface BCR. By combining drug CRISPR screens with surface-CD79B sorted screens, I uncovered both regulators of synergy and resistance to an important therapeutic and …
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Design and Synthesis of Novel Small Molecule Drugs for the Treatment of Cancer and Osteoporosis
… of hepatocellular carcinoma. To construct the drug, we utilized a technique called small molecule drug conjugate, which combines the potency of the payload and the selectivity of the targeting moiety. We designed the conjugate using a potent tubulin inhibitor, veru-111, a targeting moiety …
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