Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"drug carrier"”.
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A Study of HPMC-PEG Matrix as Drug Carrier in Spray Congealing
… of advantages in the development of specialised drug delivery systems. In this study, various grades of polyethylene glycol (PEG) and types of additives commonly used in formulating modified release dosage forms were screened for suitability as matrix material and matrix modifier for spray …
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Assembly, characterization and evaluation of a 3rd generation nanoparticle based drug carrier for metastatic breast cancer treatment
… of the patients. Low aqueous solubility, multi-drug resistance, degradation of drug, limited intra-tumor diffusion and etc. are other limitations of conventional chemotherapies and endocrine therapies. Nanoparticle based drug carriers were extensively studied for therapeutic drug delivery. Many …
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Manipulation of carrier particles for inhalation
… the relative performance of these materials as drug carriers in a dry powder inhaler (OPI). The main aim of the research was to establish whether a relationship exists between the surface characteristics of a material and the performance of the material as a drug carrier in a OP!. A fundamental …
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Synthetic polymer-collagen composite hydrogel for drug delivery and tissue engineering
… ultrastructurally and evaluated as a drug carrier by performing drug release kinetics test using FITC-dextran as a drug model. To explore its potential use as extracellular matrix in tissue engineering, the influence of composite hydrogel on cell proliferation and viability was also …
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GLYCOSAMINOGLYCAN COATED GOLD NANOPARTICLES FOR TARGETED BREAST CANCER THERAPY
… AuNP-oHA can also be used as a targeted drug carrier due to its selective cell uptake in CD44-overexpressed cells.
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Ultrasound mediated Targeted Drug Delivery In Vitro: design, evaluation and application
Background Targeted Drug Delivery (TDD) is a therapeutic modality which allows an increase in the medication dose at a treatment site, while simultaneously avoiding effects in the rest of the human body. This can be achieved via different types of delivery vehicles or carriers which encapsulate the …
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Drug-encapsulating EGF-sensitive liposomes for EGF-overexpressing cancer therapies
'Smart' targeted drug carriers have long been sought after in the treatment of epidermal growth factor (EGF)-overexpressing cancers due to the potential advantages, relative to current clinical therapies (generally limited to surgery, radiation therapy, traditional chemotherapy, and EGF receptor …
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DEVELOPMENT AND CHARACTERIZATION OF POLYMER-OIL NANOSTRUCTURED CARRIER (PONC) FOR CONTROLLED DELIVERY OF ALL-TRANS RETINOIC ACID (ATRA)
… systems are often limited by their inadequate drug loading and release properties. This study reports the integration of oil into PLGA to form the prototype of a hybrid drug carrier PONC. Our primary goal is to confer the key strength of lipid-based drug carriers, i.e. efficient encapsulation …
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Bacteria-Enabled Autonomous Drug Delivery Systems: Design, Modeling, and Characterization of Transport and Sensing
… and the low selectivity of anti-cancer drugs with respect to cancerous tissue, which also leads to high levels of systemic toxicity in patients. Thus, chemotherapy can be enhanced through improving anti-cancer drug carrier selectivity and transport properties. Several strains of gram …
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Molecular Simulation For Neurodegenerative Diseases: From Modelling Alpha-Synuclein In Aqueous Solutions To Drug Delivery Systems
… aggregation as well as amantadine for drug delivery systems. The aggregation and fibrillation of alpha-synuclein, a brain protein of 140 residues, has been linked to several neurodegenerative diseases, including Parkinson's and Alzheimer's diseases. Using molecular dynamics, …
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The characterisation of a fenoprofen prodrug
The term "prodrug" refers to a pharmacologically inactive compound that is converted to an active drug by a metabolic biotransformation. A nonenzymatic process, such as hydrolysis, can activate a prodrug via several routes. Prodrugs are mostly used to improve a drug's physical and chemical …
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Fluorinated Graphene Oxide: structure, morphology and its potential use in biological applications
… time as a potential multimodal contrast agent, drug carrier as well as a photothermal therapy. FGO is a sheet like material with oxygen and fluorine functional groups present in the structure, a complete characterization of the material is offered in the following pages. Non-cytotoxic FGO …
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Biologically Inspired Design of Protein-Silica Hybrid Nanoparticles for Drug Delivery Applications
<p>The design and application of effective drug carriers is a fundamental concern in the delivery of therapeutics for the treatment of cancer and other vexing health problems. Traditionally utilized chemotherapeutics are limited in efficacy due to poor bioavailability as a result of their size and …
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Synergistically active curcumin resveratrol solid lipid nanoparticles for treatment of melanoma
… solid lipid nanoparticles were introduced as a drug carrier to enhance the skin penetration of the aforementioned polyphenols and exploit their anti-cancer activity. Small, negatively charged curcumin and resveratrol loaded SLNs (Cur-Res SLNs) with a mean diameter of 180.17 ± 7.69 nm were …
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Development of a Dry Powder Inhaler and Nebulised Nanoparticle-Based Formulations of Curcuminoids for the Potential Treatment of Lung Cancer. Development of Drug Delivery Formulations of Curcuminoids to the Lungs using Air Jet Milling and Sonocrystallisation Techniques for Dry Powder Inhaler Preparations; and Nanoemulsion and Microsuspension for Nebuliser Formulations
… size of curcuminoids were prepared in two drug-carrier ratios (1:9 and 1:67.5). The best performance of the DPI formulations of the sonocrystallised particles, which exist in crystal structure form1, were obtained from ethanol- heptane, as illustrated FPF 43.4%, 43.6% and 43.4% with MMAD of …
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Development of Multifunctional Drug Delivery Systems for Locoregional Therapy
… systemic adverse effects. In this approach, drug is administered through topical instillation, inhalation, intra-lesional or intra-arterial injection. Decades of experience in locoregional treatment have delivered meaningful benefits to patients with localized diseases (e.g., osteoarthritis, …
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Controlled growth factor delivery from biodegradable hydrogel scaffolds for articular cartilage repair
… glycol) fumarate) (OPF) hydrogels as carriers of growth factors for articular cartilage repair has been investigated. In vitro release studies examined release of transforming growth factor-beta1 (TGF-beta1) directly from OPF hydrogels and also from gelatin microparticles encapsulated …
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Novel Implant Designs In Magnetic Drug Targeting
<p>The lack of drug selectivity to a specific site has been one of the major limitations in current therapeutic treatments. To overcome these limitations, many approaches have been proposed, one of which is magnetic drug targeting (MDT). The concept of MDT is to use drug carriers that contain a …
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Towards an improved ocular drug delivery system
… which will improve the efficiency of ocular drug delivery systems. Initially, it was necessary to review the information available on the nature of the tear fluid and its relationship with the eye. An extensive survey of the relevant literature was made. There is a common belief in the …
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Hot-melt extrusion: A versatile pharmaceutical technology
… production of solid lipid nanoparticles (SLN) as drug-carrier systems via hot-melt extrusion (HME) using Quality by Design (QbD) principles. Fenofibrate SLN were prepared by combining two processes: HME technology for melt-emulsification and high-pressure homogenization (HPH) for size reduction. …
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