Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"drug bioavailability"”.
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Cellulose Esters and Cellulose Ether Esters for Oral Drug Delivery Systems
… dispersion (ASD) is a popular method to increase drug solubility and consequently poor drug bioavailability. Cellulose ω-carboxyesters were designed and synthesized specifically for ASD preparations in Edgar lab that can meet the ASD expectations such as high Tg, recrystallization prevention and …
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Development of Topical Ophthalmic In Situ Gel-Forming Estradiol Delivery System Intended for the Prevention of Age-Related Cataracts
… safety and to estimate ocular and systemic drug bioavailability of the formulation in rabbits. </p><p> An in situ gel-forming estradiol solution eye drop containing gellan gum polymer was developed as it offers a unique advantage of solution for easy handling which then undergoes a sol-gel …
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IN VITRO ΚΑΙ IN VIVO ΜΕΛΕΤΕΣ ΓΙΑ ΤΗΝ ΕΚΤΙΜΗΣΗ ΤΗΣ ΒΙΟΔΙΑΘΕΣΙΜΟΤΗΤΑΣ ΜΕ ΒΑΣΗ ΦΥΣΙΚΟΧΗΜΙΚΑ ΧΑΡΑΚΤΗΡΙΣΤΙΚΑ ΤΩΝ ΦΑΡΜΑΚΩΝ ΚΑΙ ΤΩΝ ΦΑΡΜΑΚΟΤΕΧΝΙΚΩΝ ΜΟΡΦΩΝ
… HAVE BEEN USED, IN ORDER TO ESTIMATE THE ORAL DRUG BIOAVAILABILITY: (A) IN VITRO DISSOLUTION STUDIES IN THREE DIFFERENT SYSTEMS AND IN VIVO BIOAVAILABILITY STUDIES HAVE BEEN PERFORMED. A MONO GENERAL APPROACH FOR IN VITRO-IN VIVO CORRELATIONS OF DISSOLUTION/RELEASE CHARACTERISTICS CONSIDERING …
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Non-ionic surfactant vesicles as an Amphotericin B inhaled delivery system for the treatment of leishmaniasis
Amphotericin B (AmB) is a drug used to treat visceral leishmaniasis and fungal infections. Current available AmB formulations are limited by instability at tropical temperature, parenteral administration, renal toxicity (Fungizone®) or cost (AmBisome®, Amphotec® and Abelcet®). In this study, …
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Experimental investigation of the effect of sonication on the precipitation of grieseofluvin by impinging jets
Almost 80% of drugs on the market are manufactured as solid dosage forms, such as tablets. Drug bioavailability increases as the particle size decreases and the surface area per unit volume of drug increases. Therefore, there is a keen interest by the pharmaceutical industry to develop techniques …
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Dissolution of disintegrating solid dosage forms in a modified dissolution testing apparatus 2
… Dissolution testing serves as a surrogate for drug bioavailability through in vitro-in vivo correlation (IVIVR), and it additionally helps in guiding the development of new formulations and in assessing lot-to-lot consistency, thus ensuring product quality. The United States Pharmacopoeia (USP) …
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Nanosized systems for efficient delivery of antitumoral and anti-inflammatory drugs
… nanosuspensions were proposed to enhance dermal bioavailability of Diclofenac acid, a potent nonsteroidal anti-inflammatory drug (NSAID) with a very low aqueous solubility. T3, is a thyroid hormone normally synthesized and secreted by the thyroid gland and through interaction with its nuclear …
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Model membrane interactions with ions and peptides at the air/water interface
… peptide action, hormone-receptor interactions, drug bioavailability across the blood-brain barrier and viral fusion processes. Alteration of peptide structure could be a cause of many diseases. Biological membranes are complex systems, therefore simplified models may be introduced in order to …
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Bypassing the Blood-Brain Barrier: Cucurbit[8]uril-based Hydrogels Towards Drug Delivery Reservoirs
… towards biomedical applications, specifically as drug delivery reservoirs. Dynamic crosslinks form materials that can be stimuli-responsive, shear-thinning and self-healing. It is the application of these materials in the local delivery of cargo to post-resection tumour cavities that is the focus …
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Drug Delivery and Anti-Vascular Effects of Temperature Sensitive Liposomal Doxorubicin
… to decrease normal tissue toxicity by improving drug specificity to tumor. Relying on the EPR effect (Enhanced Permeability and Retention), a host of nanoparticles (from micelles and dendrimers to liposomes and lipidic nanoparticles) have been developed and tested for passive accumulation into …
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The development of a liposomal form Secukinumab – an IL 17 pathway inhibitor in the treatment of psoriasis
… on the development of a new way to commence drug therapy to reduce the side effects of the treatment. Our work is based on the studies of the genotoxicity of the drug Secukinumab in its bulk and liposome form using comet and micronucleus assays on lymphocytes. The results from both assays …
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The development of a liposomal form Secukinumab – an IL 17 pathway inhibitor in the treatment of psoriasis
… on the development of a new way to commence drug therapy to reduce the side effects of the treatment. Our work is based on the studies of the genotoxicity of the drug Secukinumab in its bulk and liposome form using comet and micronucleus assays on lymphocytes. The results from both assays …
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Influence of novel techniques on solubility, mechanical properties and permeability via hot melt extrusion technology
… the physico-mechanical properties as well as the drug release behavior. Ketoprofen (KTP), used as a model drug, was incorporated with hydroxypropylcellulose (HPC) (Klucel™ ELF, EF and LF) as a polymeric carrier to produce KTP amorphous solid dispersion using HME technique. Thermal gravimetric …
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SMART POLYMERIC DRUG NANOCARRIERS FOR BIOMEDICAL APPLICATIONS
… forms for the delivery of a wide array of drug formulations, because of their ability to: (i) increase the drug half-life in the blood stream, (ii) enhance the solubility of poorly-water soluble drugs, which represents the main obstacle to their efficient administration (iii) improve drug …
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Novel Use of Dual Anti-Inflammatory Therapy to Overcome Drug Resistance and Improve Functional Recovery Following Spinal Cord Injury
… Pgp limits passive diffusion of blood-borne drugs into the CNS, by actively extruding drugs from the endothelial cell membrane. Pgp can become pathologically up-regulated, thus greatly impeding therapeutic drug delivery (‘multidrug resistance’). Importantly, many drugs that have been …