Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"drug Research"”.
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A Systems Approach to Understanding the History of U.S. Pediatric Biologic Drug Research and Labeling
… to analyze the intertwined elements of the drug development system and the potential influences of the environment. Thomas Hughes's Large Technological Systems (LTS) Theory is one that could be used for this purpose; however, it falls short in its ability to address the complexity of current …
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Stem Cell-Based Immune Modulation and Regeneration
Tendinopathies, including both degenerative and inflammatory-based diseases of tendon tissue, include a significant clinical challenge, impacting millions worldwide and imposing a substantial socio-economic burden. Tendinopathies are often chronic conditions induced by an unsolved healing process …
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Efflux-Mediated Multidrug Tolerance in Replicating Mycobacteria
… longer killed by currently used antitubercular drugs that target actively growing bacteria. The dormancy model of tolerance has been the center of antitubercular drug research with the pursuit of drugs to target bacterial determinants that are expressed in the nonreplicating phase of infection. …
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Electrohydrodynamic Atomization for Improved Macromolecular Drug Delivery
<p>With advances in drug research, the use of biological therapeutics is becoming a reality. Unfortunately, methods for processing and delivering these fragile macromolecules often limit their therapeutic potential. For this dissertation, we explore the aerosolization of macromolecules by way of …
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An analytics approach to designing clinical trials for cancer
… as a treatment for cancer in the 1940s, cancer drug development has become a multi-billion dollar industry. Combination chemotherapy remains the leading treatment for advanced cancers, and cancer drug research and clinical trials are enormous expenses for pharmaceutical companies and the …
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Pharmaceutical relationships : intersections of illness, fantasy, and capital in the age of direct-to-consumer marketing
… about how the pharmaceutical industry shapes drug research. Specifically this dissertation explores the role of direct-to-consumer drug marketing (DTC) in the consumption and experience of antidepressants, including a cultural shift in the U.S. towards how the consumer negotiates new ethical …
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Tandem mass spectrometry approaches to characterizing challenging biomolecules : stapled and cyclic peptides and variants of lipid A from gram-negative bacteria
… become an intriguing class of biomolecules in drug research afforded to them because of their biological stability and resistance to proteolytic digestions. However, challenges are presented in regards to the characterization of these molecules as traditional methods are ineffective in …
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CBD & Ethanol Disrupt Early Embryonic Development
… this system can be hijacked by psychoactive drugs which ultimately alter the expression of dopamine. <em>Cannabis sativa</em> has two main active ingredients, THC and CBD, which modify the ECS receptor’s ability to bind to hormones and neurotransmitters such as dopamine. The specific effects …
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The role of USP17 in lysosome trafficking and lysosomal function
… it is required for lysosome positioning. The research presented in this thesis further confirm the role of USP17 in lysosome trafficking and explore the impact upon lysosomal function as well as its potential mechanism.<br/><br/>The data presented in Chapter 3 of this thesis shows the impact …
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The molecular structures of chlorpromazine and thiethylperazine and a discussion of the action mechanism of the phenothiazine derivatives
… phenothiazine. It is the valuable drug Largactil used in general medicine (for relief of nausea and vomiting, and radiation sickness), psychiatry (to control schizophrenic or manic states), surgery and anaesthesia (to modify or prevent traumatic and haemorrhagic shock). The drug has …
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Development of New Synthetic Approaches to Biologically-Active Peptides
Synthetic peptides are widely used in drug research due to their high selectivity and efficaciousness, as well as in chemical biology as tools for modulating protein-protein interactions. While there are a large number of naturally occurring peptides, which can be used for the development of new …
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Mechanistic studies to evaluate the targeting specificity of novel RGD Micelles to the αVβ3 integrin receptor
… therapeutic index. To overcome these challenges, research has focused its attention on the development of nano-based delivery systems that can penetrate the leaky vasculature of tumor endothelium, use site-directed ligands that can bind with high affinity and specific ity to tumor cells, …
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Innovative microphysiological systems for long-term real-time imaging in biomedicine
The discovery and development of new drugs is a complex and highly regulated process that, since its dawn, is afflicted by an intrinsic and fundamental problem: how to maintain cells or tissues alive out of human body in such a way they could behave like in vivo. So far, identification and …
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Large–scale data–driven network analysis of human–plasmodium falciparum interactome: extracting essential targets and processes for malaria drug discovery
… especially in sub Saharan Africa. Falciparum drugresistant strains, notably, to chloroquine and sulfadoxine-pyrimethamine in Africa is traced mainly to Southeast Asia where artemisinin resistance rate is increasing. Although careful surveillance to monitor the emergence and spread of …