Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 9728 for “"drug"”.
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Role of Membrane Transporters in Drug Delivery, Drug Disposition And Drug-Drug Interactions
… membrane transporters which play a vital role in drug absorption, distribution, metabolism and excretion. Understanding of functionality and molecular expression of drug transporters can prove to be of utmost importance in drug delivery or drug design by targeting specific transporter proteins. …
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Renal Drug Transporters – Clinical Significance and Role in Drug-Drug Interactions
Drug transporters play an important role in drug disposition and can be major determinants of drug pharmacokinetics, pharmacodynamics and toxicity. In contrast to drug metabolizing enzymes, which mainly concentrate in the liver and small intestine, drug transporters are expressed ubiquitously …
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Drug-drug interactions between antiretrovirals and bedaquiline
… for multiple reasons, including potential drug-interactions. Drug-resistant TB is difficult to treat and is associated with high treatment failure rates, mainly because the antimycobacterial drugs currently available are ineffective against drug-resistant TB. Bedaquiline is a new …
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Drug identification and processing of military drug offenders
The problem of drug abuse, particularly among young people, has become a major national concern. The public expects the Federal Government to provide primary leadership in solving such problems. In response, the Government has developed a number of initiatives within the military designed to …
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Remote controlled drug release in drug-eluting stents
… the most successful coronary intervention, drug-eluting stents are placed within obstructive arteries to restore blood flow to the heart and reverse life-threatening consequences. However, it is still plagued by the resurrection of artery occlusion, resulted by stent-induced restenosis.This …
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Drug discovery against malaria parasite: drug repositioning strategy
… year and there are ever present problems due to drug resistance. In this work, I used drug-repositioning strategy with bisphosphonates to discover a lead that is active against malaria in vivo. The developmental procedures include, in vitro high throughput screening, x-ray crystallography and …
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Diffusivity of drug actives in transdermal drug delivery (TDD)
Transdermal Drug Delivery (TDD) through skin patches has many advantages including the following: slow and continuous administration of the therapeutic over long periods of time, timely dosage, accessibility, kinetic maneuverability, elimination of the "First Pass Effect" and negative side effects …
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Biophysical Techniques of Transcutaneous Drug Sampling and Drug Delivery
Monitoring the time course of drug in the skin is critical for determining the frequency and dose of drug administration from safety and efficacy perspectives. Intermittent blood sampling is used as a surrogate for approximating concentration of drugs in the tissues, which leads to blood loss and …
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America's Hidden and Ignored Drug Problem: Prescription Drug Abuse
… started in the very late 1990's, is prescription drug abuse. This new epidemic not only affects the medical industry, but the criminal justice community as well. Further, in terms of prescription narcotics, primary research and media coverage into this topic revealed that numerous rural areas of …
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Evaluation of drug-drug interaction in the EHR data
Drug–drug interactions (DDIs) caused by co-prescriptions can alter the effectiveness of treatment or occurrence of adverse drug events (ADEs). Also, it in itself could be life-threatening to patients. An electronic alert for DDI is one of the most successful components of electronic medical record …
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Drug eluting prosthetic joints through drug cluster morphology control
… involving arthrodesis and amputation. Most drug eluting polymers that were in development to address this problem failed due to toxic degradation products, insufficient drug release, and insufficient mechanical strength. The gold standard of treatment uses antibiotic eluting bone cement …
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Drug Metabolizing Enzyme, Drug Transporter Expression And Drug Disposition Are Altered In Models Of Inflammatory Liver Disease
… is based on the idea that too much of a drug will cause toxicity, while too little will result in failure to elicit the desired response. A major factor in the ability of a patient to handle any dose of a drug is the capacity to metabolize and eliminate that drug from the body. For the …
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Antibiotic Drug Discovery with an Eye Towards Overcoming Drug Resistance
… of innovation and production of novel antibiotic drugs, threatens to return humanity to an era similar to one before the discovery of the first antibiotics. The need to find new agents to be used in this fight is paramount, as well as learning from our recent failures to produce such compounds. …
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Identifying drug-target and drug-disease associations using computational intelligence
Background: Traditional drug development is an expensive process that typically requires the investment of a large number of resources in terms of finances, equipment, and time. However, sometimes these efforts do not result in a pharmaceutical product in the market. To overcome the limitations of …
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Drug use and drug dealing in the rave club culture
This thesis is a ‘descriptive analysis’ of drug use and drug selling as it occurred in different leisure venues and settings and among different audiences participating in the London rave dance culture. It is an ethnographic study informed through a ‘participant observer’ approach. The main methods …
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Pharmacoepidemiology and Drug Safety: Examining Clinical Drug Trials Via Technology
This thesis provides a succinct analysis on the use of Information Technology (IT) in the fields of clinical research and pharmacoepidemiology. The primary research project explores a means of identifying a cost effective, and robust mechanism for conducting large scale clinical study using IT. The …
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CYP2D6 Inhibitory Activities of Sarpogrelate hydrochloride and Drug-Drug Interaction
… metabolite of sarpogrelate) on CYP isoforms or drug–drug interactions. Using a cocktail assay, the effects of sarpogrelate and M-1 on nine CYP isoforms were measured by specific marker reactions in human liver microsomes. Nine healthy male subjects genotyped for CYP2D6*1/*1 or *1/*2 were …
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Drug Substance and Drug Product Manufacturing Strategy Assessment for siRNAs
… Until recently, Amgen has been outsourcing the Drug Substance (DS) and Drug Product (DP) manufacturing to external manufacturers, but with a growing siRNA portfolio even beyond Asset #1, the building of a new facility is of great interest and value. As there are hundreds of potential …
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Drug of Preference
Novel excerpt
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