Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"driver gene mutations."”.
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Analysis of driver gene mutations in oesophageal squamous cell carcinoma
… on 67 samples. The mRNA levels of selected genes in OSCC were quantitated by RT-qPCR. KYSE30 cells were used for siRNA-mediated knockdown experiments targeting p14ARF and p16INK4a in OSCC. In silico structural analysis of missense mutations in p14ARF and p16INK4a was conducted using UCSF …
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Resolving the evolution of Oesophageal Adenocarcinoma using spatial and temporal sampling
… Metaplasia with GM (IM). Both BO and OAC are genetically heterogeneous lesions and little is known about the genetic relationship between OAC and pre-cancerous BO, as well as the clinical significance of GM which is not considered to be BO in the US guidelines. Furthermore, the considerable …
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Clonal Dynamics in Barrett's Oesophagus and Oesophageal Adenocarcinoma
… Both IM and OAC are known to be highly heterogeneous, but while this heterogeneity has been well studied for IM, little is known about the clonal dynamics in GM and OAC. Clonal dynamics can be explored through longitudinal or multi-sample genomic studies, or experimentally. There is no …