Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"dried blood spots"”.
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Measuring steroids from dried blood spots using tandem mass spectrometry to diagnose congenital adrenal hyperplasia
… system. As CAH is diagnosed in neonates, using dried blood spot (DBS) as specimen of choice can further improve patient care due to the very small sample volume. This study aimed to develop a more specific and rapid assay to measure seven steroids using liquid chromatography mass spectrometry …
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The Development and Validation of a Direct LC-MS/MS Assay for the Determination of Tenofovir-diphosphate in Dried Blood Spots for the Analysis of Clinical Samples
… utilising tenofovir-diphosphate (TFV-DP) in dry blood spots (DBS) through LC-MS/MS analysis, to replace the current costly and laborious indirect method currently used to elucidate adherence of patients. This indirect method faces challenges, due to the polar nature of TFV and its metabolites, …
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Α-ΦΕΤΟΠΡΩΤΕΙΝΗ ΚΑΙ ΣΥΓΓΕΝΗΣ ΥΠΟΘΥΡΕΟΕΙΔΙΣΜΟΣ
A-FETOPROTEIN (A-FP) WAS MEASURED IN DRIED BLOOD SPOTS TAKEN BY HEEL PRICK FROM525 NORMAL, 77 HYPOTHYROID AND 213 TRANSIENT HYPERTHYROTROPINAEMIC (TH) NEONATES. THE BLOOD SPOTS WERE COLLECTED AT THE TIME THE NEONATES WERE DISCHARGED FROM THE MATERNITY UNIT, I.E. BETWEEN 3RD AND 7TH DAY OF LIFE. …
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The association between circulating vitamin d levels and body composition in collegiate female athletes
… vitamin D levels determined via fingerstick and dried blood spots, followed by liquid chromatography/tandem mass spectrometry (LC-MS/MS). In addition, sunlight badges worn during a 24-hour period assessed sunlight exposure in fall and spring seasons. Estimated dietary vitamin D intake assessed …
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Population genetics and transmission dynamics of Plasmodium falciparum in the Kavango East and Zambezi regions of Namibia
… tested with rapid diagnostic tests (RDTs) and dried blood spots (DBS) were collected with corresponding epidemiological data from health districts in the Kavango East and Zambezi regions of Namibia. DNA was extracted using the chelex DNA extraction method, the parasite DNA was genotyped with …
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Longitudinal latent class and joint modelling of antiretroviral adherence
… (EAM) and tenofovir diphosphate levels in dried blood spots were more strongly associated with viral non-suppression than self-reported adherence; joint modeling revealed a stronger association between EAM adherence and viral outcomes compared to traditional survival models, with each …
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Microfluidic Interfaces for Mass Spectrometry: Methods and Applications
… used for inline quantification of amino acids in dried blood spots that have been processed by digital microfluidics. The third interface was formed by sandwiching a pulled glass capillary emitter between two digital microfluidic substrates. This method is a simpler and more direct coupling of …
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An Investigation into the Use of Dried Blood Spot Analysis in Pharmacokinetic Studies
The ethical and practical issues of obtaining a blood sample pose a significant challenge to performing pharmacokinetic studies in children, infants and neonates. Dried blood spot analysis, based on the collection of a micro blood sample has potential to overcome these difficulties. There are at …
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Dried spot cards to analyse biologic fluids for diagnostic investigation of patients
… for subsequent analysis. Methods: Samples (blood, buffy coat, serum, plasma and urine) were collected into various tubes and spotted onto filter paper cards. Concentrations of total cholesterol, triglyceride, phospholipids, glucose, lactate, and protein were measured in the original sample …
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Printable graphene sensing systems for drug and alcohol detection
… also used to analyse and detect amitriptyline in dried saliva spots and dried blood spots. Some of the advantages of the developed sensors and methods in this project are their fast response, exceptional selectivity and significantly high sensitivity that can compete with methods such as gas …
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Stability of drugs and pesticides of forensic toxicological interest and their metabolites in biological samples
… of some important drugs and compounds in blood under different storage conditions in order to optimize the preservation of these compounds. A second aim was to evaluate a new method of stabilizing these compounds in blood by storing them as dried blood spots on filter paper. The third aim …
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Study of Fat Metabolism and the Interplay with Insulin in Preterm Infants in the First Year of Life
… Feeding (CBGS-BF) at equivalent age. Dried blood spots (DBS) samples were collected and analysed for lipid metabolism using high performance - liquid chromatography mass spectrometry (HP-LCMS) at four timepoints and the analytical work is presented in Chapter 4. The ratio of specific …
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The Investigation and Application of Alternative Strategies for LC/MS based Bioanalytical Research
… plasma prepared by protein precipitation, and dried blood spots. This device was successfully utilized for the profiling of metabolites from the beta blocker drug, propranolol. Further separation of complex biofluid samples derived from axenic rats and bile from dogs again illustrated the …
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Classification of HIV virological failure using whole blood versus plasma viral load
… in low and middle income countries are whole blood testing through point of care (POC) viral load assays or dried blood spots (DBS) collected at the health facility. Utilization of whole blood instead of plasma would simplify sample collection, storage and transportation requirements and be …
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The development, validation, and evaluation of quantitative assays for determining adherence of heart failure patients to carvedilol, enalapril and perindopril
… carvedilol, enalaprilat and perindoprilat in dried blood spots (DBS) and correlated with plasma. Carvedilol, enalapril and perindopril are medications commonly used to treat HF, with enalaprilat and perindoprilat being the active metabolites of enalapril and perindopril, respectively. The …
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Rethinking Psychosocial and Energetic Influences on Cortisol, Testosterone, and Hormonal Coupling among Jordanian, Syrian, and Indigenous Qom Adolescents
… assays. Jordanian and Syrian participants had dried blood spots, which were analyzed for free cortisol and testosterone using multiple reaction monitoring mass spectrometry. I used Bayesian hierarchical models with age, log cortisol, and an age-specific log cortisol slope to estimate …
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ESTABLISHING DRIED MATRIX SPOT PROTEOMICS FOR DISCOVERY IN VARIOUS BIOLOGICAL MATRICES
… δειγμάτων σε στερεή μήτρα, γνωστή ως Dried Matrix Spots (DMS). Η μέθοδος αυτή βασίζεται στην εναπόθεση μικρής ποσότητας βιολογικού υλικού πάνω σε υποστρώματα κυτταρίνης, όπου το δείγμα αφήνεται να αποξηρανθεί πλήρως. Κατά τη διαδικασία της ξήρανσης μειώνεται σημαντικά η ενζυμική …