Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"dried blood spot"”.
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Direct analysis of dried blood spot samples
… reported herein was to identify and develop a dried blood spot (DBS) direct analysis technique that could support high sample throughput quantitative bioanalysis in a regulated drug development environment. An initial literature review, coupled with proof of concept testing of the most …
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An Investigation into the Use of Dried Blood Spot Analysis in Pharmacokinetic Studies
The ethical and practical issues of obtaining a blood sample pose a significant challenge to performing pharmacokinetic studies in children, infants and neonates. Dried blood spot analysis, based on the collection of a micro blood sample has potential to overcome these difficulties. There are at …
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ANALYSIS OF ANIONS AND PROTEINS RELATED TO OXALATE METABOLISM IN HUMAN ERYTHROCYTES
… and less-invasive diagnostic assay called Dried Blood Spot Filter Paper Assay the detection of Primary Hyperoxaluria Type 2 (PH2), a disease characterized by the dysfunction of GR/HPR. GR/HPR activity was detected in erythrocytes at levels similar other blood components such as blood …
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Development and validation of blood-based proteomic biomarker-sociodemographic diagnostic prediction models to identify major depressive disorder among symptomatic individuals
… having or developing MDD based on their blood-based proteomic profiles and other characteristics, including sociodemographic and lifestyle factors. A targeted mass spectrometry approach was used to measure the abundances of a panel of peptides representing proteins, many of which have …
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Measuring steroids from dried blood spots using tandem mass spectrometry to diagnose congenital adrenal hyperplasia
… system. As CAH is diagnosed in neonates, using dried blood spot (DBS) as specimen of choice can further improve patient care due to the very small sample volume. This study aimed to develop a more specific and rapid assay to measure seven steroids using liquid chromatography mass spectrometry …
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MORPHOLOGICAL, MOLECULAR AND GENETICAL ASPECTS OF THE ORAL CAVITY IN COVID-19 DISEASE FOR DIAGNOSIS, SURVEILLANCE, AND TISSUE REGENERATION PURPOSES
… 401 children and later in 2021 and 2022, with Dried Blood Spot test, to assess the immunological profile of a sample composed by school personnel. Further, the presence of the virus in the oral cavity was described by comparing by RT-PCR samples of lingual tissues from corpses of individuals …
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The effects of lipid-based nutrient supplements containing vitamins and minerals on renal excretion of electrolyte and tenofovir concentrations in blood among Zambian HIV/AIDS patients
… of Electrolytes and Tenofovir Concentrations in Blood among Zambian HIV/AIDS Patients by Derick Munkombwe Background: Advanced HIV-infection combined with under-nutrition and anti-retroviral therapy (ART) places patients at high risk of electrolyte abnormalities and/or losses as well as increased …
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Acceptability, safety, and patterns of use of oral pre-exposure prophylaxis to prevent HIV in healthy, South African adolescents
… diphosphate (TFV-DP) levels as measured in dried blood spot samples were detectable (>16fmol/punch) in 92% (108/118)) of participants who reported PrEP use at week 12, 74% at week 24 (74/100), and 58% (22/37) by the end of the study. One HIV seroconversion occurred during the study (0.76/100 …
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Emerging Patterns of Substance Use and Buprenorphine Nonadherence
… different syringe service programs using a novel dried blood spot (DBS) assay. We found that methamphetamine use was more prevalent in the Western U.S. whereas cocaine use was higher in the Eastern U.S. Xylazine and fentanyl were predominantly found on the East Coast. Using DBS assays may be an …
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Contemporary challenges in clinical pharmacy practice - medicines optimisation and medication adherence
… direct measurement of metformin concentration in dried blood spot (DBS) samples, prescribing and dispensing records, and patient interviews. The DBS sampling approach was coupled with population pharmacokinetic (PopPK) modelling, which took account of patient characteristics, metformin dosage and …
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The Plasma, Whole Blood and Intracellular Concentrations of Antiretroviral Agents in South African Children Receiving Combination Antiretroviral Therapy with and without Concomitant Antitubercular Treatment
… friendly method which requires small volumes of blood, and inexpensive processing and storage conditions. Furthermore, because HIV replicates in the cells, efavirenz and lopinavir need to penetrate into these infected cells to inhibit viral replication. Therefore, directly measurement of …
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Development and Validation of Quantitative PCR Assays for DNA-Based Newborn Screening of 22q11.2 Deletion Syndrome, Spinal Muscular Atrophy, Severe Combined Immunodeficiency and Congenital Cytomegalovirus Infection
The development of new high throughput technologies able to multiplex disease biomarkers as well as advances in medical treatments has lead to the recent expansion of the newborn screening panel to include DNA-based targets. Four rare disorders; deletion 22q11.2 syndrome and Spinal Muscular Atrophy …