Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"doxycycline"”.
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Polymer Based Delivery Of Doxycycline Hyclate For The Prevention Of Peri-Implant Mucositis Infection
… in patient compliance. Local delivery of doxycycline may decrease the systemic toxicity of the drug and can also save time and money for the patient in the long run. The aim of my study is to formulate and characterize the release of doxycycline from the polymer matrix and also to reduce …
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Understanding the Influence of Bureaucratic Caring on Implementation of Doxycycline Post-Exposure Prophylaxis: A Multiple Case Study
Despite its demonstrated effectiveness, doxycycline post-exposure prophylaxis (doxyPEP) has not been included in local response strategies for STI outbreaks. The challenges surrounding doxyPEP implementation are not fully understood in the southern United States, and further research is needed to …
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Trends in Chlamydia trachomatis Treatment Prescribing Practices in King County, Washington, 2010 - 2018
… either azithromycin (1 gram as a single dose) or doxycycline (100mg twice daily for 7 days) to only recommending doxycycline as first line treatment after 2021.We conducted a trends analysis using the Washington STD surveillance database to understand which patients and providers may be most …
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Does the human skin microbiome adapt to antibiotic exposure?
… to antibiotics such as erythromycin and doxycycline, and later formed adaptive resistance. Erythromycin adapted strains were found to be resistant to erythromycin and cross- resistant to doxycycline based on both disk diffusion assay and MIC results. Doxycycline adapted strains formed …
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Matrix metalloproteinases in the equine systemic inflammatory response: implications for equine laminitis
… MMP activity in all studies. The abilities of doxycycline, oxytetracycline, and flunixin meglumine to inhibit LPS-induced equine MMP-2 and MMP-9 activities in vitro were investigated using a digital laminar explant model. The structural integrity of the explants was tested using an Instron …
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Structure-Based Drug Design Against a Biosecurity Pathogen
… C. burnetii is sensitive to the antibiotic doxycycline, which can clear acute disease. However, extended combinatorial treatment with hydroxychloroquine is required to manage chronic Q-fever. As a result, there is interest in developing novel anti-Coxiella inhibitors. Here, we approach this …
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PREPARATION AND CHARACTERIZATION OF AN ELECTROSPUN GELATIN/DENDRIMER HYBRID NANOFIBER DRESSING
… non-toxic, and easily available. The antibiotic, doxycycline, has the ability to inhibit matrix metalloproteinases. Matrix metalloproteinases, which occur in excess in chronic wounds, degrade the reconstituted ECM. Starburst™ polyamidoamine (PAMAM) dendrimer G3.5, which provides a versatile and …
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Autophagy maintains the homeostatic environment in the male reproductive organs playing a key role in fertility
… accessory sex organs remains unknown. Using a doxycycline-inducible short hairpin (shRNA) mouse model (called ATG5i) targeting Atg5, we created a mouse model that demonstrates ubiquitous inhibition of autophagy. With this model, we investigated the effects of autophagy inhibition and …
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Defect of Mitochondrial Translation Machinery Enhances Hepatoma Cell Invasiveness
… 4. Mt-TMD-related invasive behavior induced by doxycycline in SNU-387 cells 20 5. Claudin-1 regulates Mt-TMD-induced hepatoma cell invasiveness. 26 6. Impact of doxycycline on gene expression 30 IV. DISCUSSION 33 V. CONCLUSION 36 REFFERENCE 37 국문요약 43
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Investigating the functions of PGC-1 isoforms in retinal pigment epithelia metabolism and their implications on age-related macular degeneration
… cells. The cells were exposed to 0.01-100µg/ml doxycycline for 48-hours and qPCR was used to measure gene expression. Transfected cells were treated with ZLN005 and cell death upon exposure to oxidative stress was quantified. RESULTS: Gene expression analysis on ARPE-19 cells treated with ZLN005 …
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In Vitro Models of Cellular Dedifferentiation for Regenerative Medicine
… this will be achievable. Second, we used a doxycycline-inducible lentiviral vector encoding the transcription factors Oct4, Sox2, cMyc, and Klf4 to create a line of naive-like porcine induced pluripotent stem cells (iPSCs). This reprogramming vector was verified first in murine cells, the …
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Improvement and establishment of the tTA-dependent inducible system in the mouse brain
… htTA was efficiently suppressed by addition of doxycycline. To express the htTA in a neuron- and region-specific manner in mouse brain, the region-specific promoter of the KA1 was chosen. The htTA gene under the KA1 promoter appears to be expressed too low to induce tTA responsive genes (e.g. …
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Transgenic use of SMAD7 to suppress TGFß signaling during mouse development
… system, expression of Smad7 was induced via doxycycline in the majority of pre- and post-migratory NCC lineages (via Wnt1-Cre mice). Further, expression of Smad7 was induced via doxycycline in a subset of post-migratory NCC lineages (via Periostin-Cre mice, after the NCC had reached their …
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Targeting Coenzyme A Biosynthesis for Antifungal Development.
… contrast, the growth of C. albicans strains with doxycycline repressible expression of PAN6 (PTETO-PAN6) or CAB1 (PTETO-CAB1), was arrested in the presence of doxycycline, even in medium supplemented with pantothenate. Furthermore, overexpression of C. albicans FEN2 was not sufficient to restore …
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Coronary Artery Outcome in Kawasaki Disease: The Role of Matrix Metalloproteinase-9 and Therapeutic Modulation of Its Activity
… directly inhibited by the metal-chelating drug doxycycline. Treatment of affected mice with doxycycline significantly improved coronary outcome. Inhibiting both the inflammatory response as well as the downstream effects of inflammation were of therapeutic value in this model of KD. These …
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The Role of FGF Signaling in the Regulation of Adult Murine Cardiomyocyte Contractility and Pathologic Hypertrophy
… reactivated following injury. I utilized a doxycycline-inducible, cardiomyocyte-specific, constitutively-active FGF receptor (caFGFR1) mouse model to test whether the cardiomyocyte has the capacity to respond to a cell autonomous FGF signal. Induction of this transgene led to immediate …
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Impact loading and functional tissue engineering of articular cartilage
… IGF-I, or matrix metalloproteinase inhibitor doxycycline partially ameliorated cell death and sGAG loss, two detrimental changes that occurred following either Low or High impact. With 1 week of treatment after Low impact, P188 reduced cell death 75% and IGF-I decreased sGAG release 49%. …
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Approaches towards therapeutic development against chronic brucellosis in a mouse model
… for iron. Additionally, it was found that doxycycline-gentamicin (DG) treatment results in better clearance of Brucella from infected mice compared to doxycycline alone. Secondly, two vaccine candidates, irradiated B. neotomae (IBN) and outer membrane vesicles (OMVs), were tested as …
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Development of a tool for tracking H3K27 tri-methylation
… GFP that can be induced with treatment with doxycycline. Different numbers of guide RNAs were also used in an attempt to increase CRISPR/Cas9 efficiency. These cell lines were screened and analyzed for future use in live cell imaging and in vivo experiments concerning the interplay of H3K27 …
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The effects of some antibiotics and lipopolysaccharide on oxidative burst and phagocytosis of neutrophils
… Ceftriaxone, ciprofloxacin, clindamycin, doxycycline, enoxacin, imipenem, norfloxacin, pefloxacin, teicoplanin, tetracycline and vancomycin. Blood from healthy subjects was exposed to concentrations of the above antibiotics ranging from 0.1 to 200 μg/ml for 60 minutes. EDTA and bacterial …
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