Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 136 for “"downstream signaling"”.
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Unraveling the intricacies of spatial organization of the ErbB receptors and downstream signaling pathways
… receptor aggregation and predict the effects of downstream signaling. The coupled spatial non-spatial simulation algorithm, CSNSA is a tool that I took part in developing, which implements a spatial kinetic Monte Carlo for capturing receptor interactions on the cell membrane with Gillespies …
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The serotonin (5-HT) 2C receptor (5-HT2CR) and its downstream signaling components: Distinct adaptations in cortical circuits associated with cocaine exposure
… regimen, suggesting that 5-HT2CR function or its downstream signaling components are significantly altered. Cortical brain areas, including motor cortex and prefrontal cortex (PFC), are important sites of action for 5-HT2CR control of cocaine-induced behaviors and are strongly implicated in …
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Proteogenomic Insights Into The Nature Of Chemoresistance In Chronic Myelogenous Leukemia
… uncontrolled cell proliferation by deregulating downstream signaling pathways.
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Oncogene-Induced Signaling Heterogeneity in Lung Cancer
… genes can be targeted therapeutically. Study of downstream signaling alterations of these oncogenes and tumor suppressor genes may identify novel therapeutic targets. Although studies on genetic heterogeneity in subclonal populations within one tumor using deep sequencing and multiple sectioning …
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Functional characterization of human and chicken TLR3
… viral double-stranded RNA (dsRNA) and initiating downstream signaling pathways, including activation of the transcription factor NF-κB. While TLR3 function has been extensively characterized in humans and other mammals, little is known about its activity in avian species such as chickens, which …
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Toward the understanding of TIR-NB-LRR–mediated immunity; study of the AvrRps4 recognition model in Arabidopsis
… NB-LRR proteins recognize effectors and induce downstream signaling events are poorly known. This PhD work focused on the characterization of TIR-NB-LRR–mediated immnunity in plants. In Arabidopsis, two TIR-NB-LRR encoding R genes, RRS1 and RPS4, are in a head-to-head arrangement on chromosome …
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The Role Of Pkc Epsilon In Breast Cancer Cell Surface Polyfibronectin Assembly And Pulmonary Metastasis
… cell surface polyFn. In order to investigate the signaling pathways involved in polyFn assembly, we utilized pharmacological inhibitors for various signaling pathways that have been proposed to regulate cellular function. Mutant plasmid expression, siRNA knockdown of proteins and biochemical …
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Dual mTOR/HDAC Inhibition: Preclinical Development of a Novel Breast Cancer Therapy
… resistance often develops due to activation of downstream signaling pathways, including phosphoinositide 3 kinase-AKT/protein kinase Bmammalian target of rapamycin (PI3K/AKT/mTOR), despite effective upstream receptor inhibition. Activation of this pathway increases ribosome biogenesis and …
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Angiotensin Type-2 (At2) Receptor Modulation of Nmda-Mediated Current, Signaling and Apoptosis
… with Ang II regulates NMDA-mediated current, signaling and apoptosis. Western blot analysis revealed that Ang II, acting primarily through AT2 receptor activation of the protein phosphatase 2A (PP2A), attenuated NMDA-mediated increases in extracellular regulated kinase-2 (ERK-2) activity. We …
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Investigation of the Function and Regulatory Mechanisms of the Mammalian Target of Rapamycin
… this shuttling is required for its cytoplasmic signaling. I have further investigated the regulation and function of mTOR cytoplasmic-nuclear shuttling. A systematic screen of mTOR revealed a rev-like NES sequence within mTOR at amino acids 1281--1289, which displayed robust nuclear export …
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Tetraspanin CD9: Contributions to Cancer Cell and Vascular Cell Phenotypes from the Sixth Man
… organization is a prerequisite for cellular signaling to occur. Deregulation of cellular signaling often precedes the formation of cancer or vascular disease phenotypes. This insinuates the necessity to understand how tetraspanins contribute to membrane organization and subsequent downstream …
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The Role of Erbb2 in Ultraviolet-Induced Nonmelanoma Skin Carcinogenesis
… 1. Determine biological processes and downstream signaling modulated by Erbb2 in response to UV irradiation. (Chapter 2) 2. Determine the biological significance of Erbb2 activation during UV- induced tumorigenesis. (Chapter 3) 3. Determine the mechanisms through which Erbb2 enhances …
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Involvement of The Receptor For Advanced Glycation End Products (Rage) In Progression of Pancreatic Cancer
… agonists were found to increase Ras activity and downstream signaling in a time- and dose-dependent manner. Likewise, inhibition of RAGE decreased Ras signaling activity and downstream signals in multiple PDAC cell lines. In vivo, inhibition of RAGE activity using an antagonist inhibited tumor …
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Investigating The Role of Cd109 In Pancreatic Ductal Adenocarcinoma
… cancer progression through activation of downstream signaling. We believe therefore that targeting CD109 could improve PDAC patients’ survival. Here we report that CD109 plays a role in cell proliferation, viability, and clonogenicity in vitro. We also find that it promotes tumor formation …
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Quantitative analysis of the T cell receptor signaling network in response to altered peptide ligands
… ligands. We investigated how the consequent downstream signaling networks integrate to ultimately govern avidity-appropriate T cell responses in this hybridoma system. Here, we hypothesized that a quantitative combination of key downstream network signals can effectively represent the …
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EFFECT OF ANGIOTENSIN PEPTIDES ON VASCULAR REMODELING
… by dephosphorylating MAP kinase to inhibit downstream signaling pathways.
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The Role of the ITAM-containing CEACAM3 Receptor in the Neutrophil Response to Infection by Neisseria gonorrhoeae
… of the tyrosine kinase, Syk, which initiates downstream signaling responsible for the antimicrobial responses of neutrophils. These data contribute to the knowledge of how seemingly unrelated receptors of neutrophils (such as the IgG-binding Fcγ receptors, the fungal receptor Dectin-1, and the …
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Dhhc5 Regulates Beta-Adrenergic Signaling In The Heart Through Palmitoylation of G Alpha Proteins
… after cellular stimulation supporting a direct signaling role for this posttranslational modification. The work in this dissertation investigated whether β-adrenergic stimulation led to stimulus-dependent palmitoylation of downstream signaling proteins in immortalized and primary cell models. I …
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Investigating the role of ICL3 in β1-adrenergic receptor activation
… energy landscape as they regulate complex downstream signaling processes. The thermostable turkey β1-adrenergic receptor (tβ1AR) is a prototypical class A GPCR widely used in structural studies and is activated by catecholamine ligands, adrenaline, and noradrenaline. Although many crystal …
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