Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 602 for “"downregulation"”.
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Downregulation of Pax2 Suppresses Ovarian Cancer Cell Growth
… in apoptosis, which supports the fact that downregulation of PAX2 in PAX2-expressing ovarian cancer cells inhibits cell growth. We hypothesize that this growth inhibition is due to upregulation of the tumor suppressor gene <em>G0S2</em> via induction of apoptosis. PAX2 represents a potential …
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Metabolic downregulation during diapause in embryos of Artemia franciscana
… the embryos of <i>A. franciscana</i>, and hence downregulation of trehalose catabolism results in severe limitation of metabolic fuel available to the embryo during diapause. Western blot data demonstrates that pyruvate dehydrogenase becomes phosphorylated during entrance into diapause, and as a …
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The mechanism of HIV-1 Nef-mediated downregulation of CD4
… cells. Early studies suggested that Nef induces downregulation by linking the cytosolic tail of CD4 to components of the host-cell protein-trafficking machinery. However, the specific sorting pathway that Nef uses to modulate CD4 expression remained uncertain. According to one model, Nef was …
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Hypoxia Mediated Downregulation of Mirna Biogenesis Leads to Increased Tumor Progression
… leads to attenuation of miRNA biogenesis by downregulation of two key enzymes, Drosha and Dicer in cancer cells. Previous data from our laboratory had shown the clinical relevance of downregulated Dicer and Drosha in ovarian and other cancer types, but a clear mechanistic understanding is …
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Downregulation of Prdm16 Is Critical for HOXB4-mediated Benign HSC Expansion In Vivo
… by HOXA9 and HOXA10, suggesting that Prdm16 downregulation was involved in preventing leukemia in HOXB4 transplanted mice. Functional evidence to support this mechanism was obtained by enforcing co-expression of sPrdm16 and HOXB4, which led to myeloid expansion, and leukemia. Before the onset …
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Downregulation of reproductive homeobox gene 6 (RHOX6) interferes with male germ cell differentiation
… Rhox6 transcripts and we found that continuous downregulation of Rhox6 expression resulted in dramatic decrease in the number of germ cells differentiated. Collectively, these results suggest that downregulation of Rhox6 impairs differentiation of PGCs.
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Downregulation of miRNA expression in malignant germ cell tumours: mechanism and functional significance
Germ cell tumours (GCTs) are clinically and pathologically heterogeneous neoplasms that arise at gonadal (testicular/ovarian) and extra-gonadal sites. The chemotherapy burden for patients with malignant germ cell tumours (mGCTs) that require treatment results in substantial longterm side-effects, …
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Targeting Kremen1 Downregulation with RVG-9R/siRNA Complexes in the Triple-Transgenic Mouse Model of Alzheimer’s Disease
… for analysis. The brains were analyzed for Krm1 downregulation at the protein and mRNA levels via Western blot and qPCR, respectively. In 4 month old mice, WT mice showed the lowest levels of Krm1 protein and mRNA expression levels and 3xTg-AD CPep/siRNA treated mice showed the highest. The 4 …
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Downregulation of miR-10a-5p as a Potential Therapeutic Target to Improve the Detrimental Effects of Post-stroke Social Isolation
<p><strong>Introduction </strong></p> <p>Social isolation is detrimental to health. Isolation and loneliness are linked to all-cause mortality and accelerated disease progression in patients with cancer, dementia, and vascular disease. The number of individuals that live alone is increasing in our …
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CDDO-ME induces apoptosis in breast cancer cells via Ca2+ influx-mediated dilation of endoplasmic reticulum and c-FLIP downregulation
… and subsequent apoptosis 51 5.c-FLIPL downregulation plays a critical role in CDDO-ME-induced apoptotic cell death, but not in vacuolation 58 6.Higher increase in intracellular Ca2+ and ROS levels as well as c-FLIP downregulation may contribute to a more potent anti-cancer effect of …
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Elucidating the Function of Krüppel Homolog 1 (Kr-h1) Associated Proteins (KAPs) in Aedes aegypti Reproduction Through RNA Interference-Mediated Downregulation
The transcription factor Krüppel homolog 1 (Kr-h1) is crucial in multiple reproductive processes of Aedes aegypti mosquitoes, including previtellogenesis, vitellogenesis, and oogenesis. This study explores the interaction between Kr-h1 and its potential associated proteins (KAPs), with a specific …
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Real Time RT-PCR for Direct Detection of Viable Mycobacterium Avium Subspecies paratuberculosis in Chron's Disease Patients and Association of Map Infection with Downregulation in Interferon-Gamma Receptor (INFG1) Gene in Crohn's Disease Patients
… we previously demonstrated a possible downregulation in the Interferon-gamma receptor gene (IFNGR1) in patients with active Crohn's disease using microarray chip analysis. In this study, measurement of RNA by real time qRT-PCR indicated a possible downregulation in 5/6 CD patients …
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Characterization and informed design of downregulating anti-epidermal growth factor receptor antibodies
… clustering, leading to synergistic receptor downregulation and anti-tumor activity. The aim of this thesis is to elucidate the details of this phenomenon and to exploit this mechanism to design more effective therapeutic antibodies targeting EGFR. We first illuminate several key aspects of …
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Preneoplastic hepatocyte hypothyroidism underlies hepatocellular carcinoma progression
… (RH model) of rat hepatocarcinigenesis, we found downregulation of THRβ1 and THRα1 in most of early preneoplastic lesions and of HCCs. THRβ1 and, to a lesser extent, THRα1 downregulation was observed only in preneoplastic lesions positive for the progenitor cell marker cytokeratin-19 (KRT-19), …
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Functional Characterization of the HIV-1 NEF Acidic Cluster
… some of its in vitro effects including: (1) the downregulation of major histocompatibility complex I (MHC-I), (2) the downregulation of CD4, (3) infectivity enhancement, and (4) Pak2 activation. These in vitro effects, with the exception of CD4 downregulation, rely in part upon Nef's acidic …
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