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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 432 for “"down-regulation"”.

  1. Ubiquitination of EpoR and p85 in Ligand Induced EpoR Down-Regulation

    Bulut, Gamze Betul2016

    … cells EpoR signaling is also subject to negative regulation. Mutations in EpoR or JAK2 that abrogate negative regulation cause erythrocytosis in hematological malignancies. Primary familial and congenital polycythemia (PFCP) is a proliferative disorder characterized by erythrocytosis and …

    utswmed Repository record

  2. Down-Regulation of CXCR2 Expression on Human Polymorphonuclear Leukocytes by TNF-α

    Asagoe, KosukeKyoto University1998

    kyoto Repository record

  3. The down-regulation of Ku70, DNA-PKcs, and Parp-1 in mammalian cell lines

    Wickersham, Stephanie2012

    lethbridge

  4. The Role of B-Arrestin in Agonish-Induced Down-Regulation of the M1 mAChR

    Wilham, Laura Elizabeth

    … THE ROLE OF â–ARRESTIN IN AGONIST-INDUCED DOWN-REGULATION OF THE M1 mAChR Chair: Darrell A. Jackson G protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors. They mediate diverse cell signaling pathways and therefore are currently the target for 50% of all …

    montana-tech Repository record

  5. The Role of B-Arrestin in Agonish-Induced Down-Regulation of the M1 mAChR

    Wilham, Laura Elizabeth

    … THE ROLE OF â–ARRESTIN IN AGONIST-INDUCED DOWN-REGULATION OF THE M1 mAChR Chair: Darrell A. Jackson G protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors. They mediate diverse cell signaling pathways and therefore are currently the target for 50% of all …

    montana Repository record

  6. Characterization of the down regulation of antibody production in high cell density perfusion culture

    Morrill, Joyce CatherineMassachusetts Institute of Technology1994

    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Applied Biological Sciences, 1994.

    mit Repository record

  7. Down-Regulation of Natural Killer Cell Activation in Response to Influenza Virus in Older Adults

    Jing, Yu2019

    … soluble factors and cell-cell contact factors is down-regulated in elderly subjects compared to young subjects in response to influenza virus. As for soluble factors, IFN-o: and IFN- 7 are proven to be important in inducing NK cell to produce IFN-7 . The frequencies of IFN-a-producing plasmacytoid …

    odu Repository record

  8. Germ cell nuclear factor is not required for the down-regulation of pluripotency markers in fetal ovarian germ cells

    Okumura, Leah MMassachusetts Institute of Technology2012

    … It is not yet clear why pluripotency markers are downregulated with this particular timing, nor is it understood what factors are involved in their repression. I have examined in fetal ovarian germ cells the expression and function of Gcnf (germ cell nuclear factor), an orphan nuclear receptor …

    mit Repository record

  9. Vitamin D- induced down regulation of RAD51 in head and neck squamous cell carcinoma (HNSCC), In Vitro and In Vivo

    Hautea, Rhea P.2018

    … application of VD<sub>3</sub>to hamsters downregulates Rad51 expression in the buccal pouch and hinders the onset of tumor formation. Rad51 is a protein that plays a critical role in cell proliferation and homologous recombinational DNA repair. In the in vitro model, we show that Rad51 …

    u-pacific Repository record

  10. Intercellular adhesion molecule-1 mediates the inhibitory effects of hyaluronan on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts via down-regulation of NF-κB and p38

    Hiramitsu, TerukoKyoto University2006

    kyoto Repository record

  11. Role of Hydroxy acid oxidase 2 (Hao2) in hepatocellular carcinoma

    MATTU, SANDRAUniversità degli Studi di Cagliari2015

    … model, revealed that Hao2 was among the most down-regulated genes in HCCs developed, 14 months after initiation with a single dose of the hepatocarcinogen Diethylnitrosamine (DENA). Next, we investigated whether Hao2 down-regulation is an early event during liver carcinogenesis; to this aim, …

    cagliari Repository record

  12. Role of Cell Death Regulatory Genes and Radiation Response in Pancreatic Adenocarcinomas

    Alcock, Rachael AUniversity of Central Lancashire2002

    … ras inhibits TGF-P signalling through the down-regulation of RII expression and abrogates apoptotic pathways through down-modulation of PAR-4 gene expression. A majority of pancreatic turnours harbour K-ras point mutations and these mutations dysregulate, the growth inhibition and apoptosis …

    cent-lancashire Repository record

  13. Cellular regulation of platelet glycoprotein VI : in vivo and in vitro studies in mice

    Rabie, TamerUniversität Würzburg

    … presented here focused on studying the cellular regulation of GPVI. In addition, a possible role for GPVI in thrombus formation induced by atherosclerotic plaque material was investigated and it was found that GPVI plays an important role in this process. Using a recently published mitochondrial …

    wurz-thes Repository record

  14. FATE OF Cx43 IN CARDIAC AND EPIDERMAL TISSUES HARBOURING A DISEASE-LINKED Cx43 MUTANT

    Manias, Janet L.2007

    … mouse model of ODDD there would be significant down-regulation of total Cx43 yet minimal compromise to cardiomyocyte or kératinocyte function. Cardiac and epidermal tissue from Gjal* mice revealed a 60-75% reduction in Cx43 protein. Compensation via the up-regulation of Cx40 or Cx45 was not …

    uwo Repository record

  15. Down-modulation of the apoptosis receptor Fas and the EGF receptor by the adenovirus E3/10.4-14.5K proteins requires the concerted action of two distinct transport signals

    Hilgendorf, AnnetteLudwig-Maximilians-Universität

    … E3/6.7K. In a process referred to as receptor down-regulation, 10.4-14.5K relocates receptor targets from the cell surface to lysosomes for degradation. The aim of this study was to characterize functional determinants within the Ad2 10.4-14.5K proteins, that are required for down-regulation of …

    lmu-germany Repository record

  16. Functional role of GSK3β in p38MAPK mediated human amnion membrane senescence

    Lavu, NarmadaThe University of Texas Medical Branch at Galveston2021

    … glycogen synthase kinase (GSK) 3β and its regulation by p38MAPK in effecting senescence to further delineate the molecular mechanism involved in senescence. We report that OS resulted in phosphorylation of GSK3β (inactivation) and p38MAPK (activation) that was associated with cell cycle …

    utmb Repository record

  17. Targeted Inhibition of Sp1 Transcription Factor and Anti-Angiogenesis of Human Pancreatic Cancer

    Jia, Zhiliang2010

    … effect are unclear. The understanding of Sp1 regulation on VEGF and their interactions has significant clinical implications. Sp1 and VEGF expression and microvessel density (MVD) were analyzed using pancreatic cancer patients specimens through immunohistochemistry staining. The impact of Sp1 …

    uthsc Repository record

  18. The Role and Mechanism of Enhanced Met Expression in Pancreatic Cancer

    Hill, Kristen S 1982-The University of Texas Medical Branch at Galveston2016

    … tumor growth using shRNA mediated knock down of Met in two pancreatic adenocarcinoma cell lines. I showed that cells with reduced Met protein exhibited reduced growth in soft agar, cell motility and tumor growth in vivo; supporting the conclusion that the HGF/Met signaling axis functions …

    utmb Repository record

  19. The Role of Emotion Regulation in Promoting Prosocial Sibling Relationships

    Kubose, Denise KennedyUniversity of Illinois at Urbana-Champaign2015

    Emotion regulation has been recognized as a significant component of children's social development that plays a predominant role in helping to establish prosocial interactions with family members and peers (Blair, Denham, Kochanoff, & Whipple, 2004). Conflicts between siblings represent a …

    uiuc Repository record

  20. The immune-modulating activity of Sutherlandia frutescens

    Kisten, NajwaUniversity of the Western Cape2010

    … whole blood cell cultures reflects a significant down regulation of Interleukin(IL) 6 and IL-10 compared to the control (P<0.05) hence suppressed the inflammatory and humoral immune response. Results obtained for Inteferon-gamma (IFN ) shows that Sutherlandia frutescens is donor specific as it …

    western-cape Repository record

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