Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"double strand DNA breaks"”.
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Quantitative, Comparative Toxicity and Toxicogenomic Analyses of Nitrogenous Drinking Water Disinfection by-Products
… genotoxicity involves the generation of double strand DNA breaks. The work presented in this dissertation filled a large void in drinking water disinfection toxicity literature. This work serves as a foundation for future mechanistic toxicology of DBPs.
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BIOLOGICAL CHARACTERIZATION OF TWO PUTATIVE DNA METABOLISM ENZYMES IN DEINOCOCCUS RADIODURANS
… FtsK is a bacterial protein that translocates double-stranded DNA during cell division. In archaea, herA is an essential gene that encodes an enzyme believed to be important for recombinational DNA repair. It is typically found in an operon with a gene that codes for a nuclease, nurA. Homologs …
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The role of the human endonuclease VIII-like 1 and 3 in the repair of DNA replication blocking lesions
The endonuclease VIII family of DNA glycosylases initiate repair of oxidative DNA base damage through BER and have been shown to resolve DNA inter-strand crosslinks (ICLs), arising from exogenous agents. Human NEIL1 (hNEIL1) activity on psoralen generated mono-adducts (MAs) and three-stranded DNA …
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Dose-rate-effects in XRCC1 wild-type and mutant CHO cell lines using An ²⁴¹AM source
… since the inability to rapidly respond to DNA damage would result in the gradual accumulation of cytotoxic double strand DNA breaks and/or chromosome exchanges/aberrations. The cells were irradiated for 7 days with photons from unencapsulated 241Am plate sources for chronic, low-dose-rate …
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Identifying a role for Ciz1 in the DNA damage response
In proliferating cells, cell cycle arrest and DNA repair are induced upon detection of DNA damage. The DNA damage response (DDR) to double strand DNA breaks is mediated by phosphatidylinositol 3-kinase-like protein kinases (PIKKs), which propagate DDR signalling by phosphorylating SQ/TQ motifs in …
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Effects of altered expression of the sumo conjugating enzyme, UBC9 on mitosis, meiosis and conjugation in Tetrahymena thermophila
… regulate nuclear events such as transcription, DNA repair and mitosis. The segregation of the <em>Tetrahymena thermophila</em> genome into two different nuclear compartments provides an unusual context for the analysis of SUMOylation. Each cell contains a transcriptionally silent, diploid germ …
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The anti-cancer activity of extracts derived from millets and Kraalbos
… with antibodies to γH2AX showed that KB2 induced double strand DNA breaks in breast cancer cells. Flow cytometry and western blotting with antibodies to p53, p21, cyclin A and cyclin B1 further revealed that KB2 causes breast cancer cells to arrest in the S and G2/M phases. A sub-G1 peak, …
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PARP inhibition in combination with radiation therapy for the treatment of feline oral squamous cell carcinoma
… (PARP) is a key molecule involved in single stranded DNA break repair. PARP inhibitors (PARPi) are predicted to amplify RT-induced lethal DNA damage, and combinatorial strategies with PARPi and RT are being investigated for treating human solid tumors. We hypothesized that Olaparib, an orally …
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The nature of the synergistic lethality of nitric oxide and hydrogen peroxide in Escherichia coli and its effect on chromosome fragmentation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01