Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"double membrane vesicles"”.
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Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum
… from its host cytosol which it transports within double membrane vesicles to the digestive vacuole, where digestion occurs and metabolites are used mostly for nutritional purposes. To gain a deeper understanding of the molecular basis and mechanisms of this vital process, a panel of inhibitors was …
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The Regulation of Autophagy and Its Role in Mitotic Exit
… in which cells enclose cytoplasmic contents in double membrane vesicles and deliver them to the lysosome for degradation. Autophagy plays critical regulatory roles in cancer, aging, neurodegeneration, immunity and many other physiological processes. Autophagy can be induced by multiple …
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Isolation and characterization of dengue virus membrane-associated replication complexes from Aedes aegypti
… have long observed proliferation of host membranes. Membrane-bound replication compartments have recently been isolated and characterized from flavivirus-infected mammalian cells, providing insight into the morphology, organelle of origin, and protein components of the flavivirus …
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Understanding the Host Cellular Response to Astrovirus Infection
… often exploit autophagy machinery to create double membrane vesicles (DMVs) as sites of replication and to protect viral RNAs from detection by innate immune sensors. In these studies, we provide the first evidence that astrovirus exploits some, but not all autophagy machinery to assist in …
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A study on non-canonical autophagy signalling
… the engulfment of intracellular content in double-membrane vesicles known as autophagosomes, which fuse with lysosomes for the degradation and recycling of the autophagic cargo. Nutrient starvation leads to the induction of autophagy by activating the master regulator AMP-activated protein …
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Coronavirus Replicase Proteins: Multifunctional Mediators of Replication and Innate Immunity Evasion
… 3C-like (3CLpro) proteases. The nsps modify host membranes to produce double membrane vesicles (DMVs) upon which the replicase-transcriptase assembles and synthesizes viral RNA. nsp3, nsp4, and nsp6 are integral membrane proteins believed to be involved in DMV formation. Work presented here …
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Characterisation of a novel interaction partner for Atg16L1 and its role in regulating autophagy
… to starvation, resulting in the formation of double-membrane vesicles known as autophagosomes. These sequester cytoplasmic contents to the lysosome, where they are degraded to generate amino acids which can be used for protein synthesis during periods of nutrient deprivation. Membrane …
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Role of BEC-1/Beclin 1 and Autophagy Genes in <i>C.elegans</i> Germline Cell Proliferation
… is characterized by the formation of distinctive double-membrane vesicles (autophagosomes) that engulf unnecessary cytoplasmic components, such as organelles and long-lived proteins. Failure to remove protein aggregates and/or damaged organelles, via autophagy, has been implicated in various …