Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 429 for “"dose-response"”.
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Personalising Inhaled Corticosteroid Dose Response in Persistent Asthma
… theme of inhaled corticosteroid (ICS) dose response effects on a variety of asthma outcome measures; with further importance placed on the application of these findings to personalising ICS dosing for the individual asthmatic.<br/><br/>The introduction provides a detailed summary of the …
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Improving The Accuracy of Radiation Pneumonitis Dose Response Models
… been reported to be 15%. Studies have shown that dose escalation to the tumor can lead to better local control and subsequently better overall survival. However, dose to lung tumor is limited by normal tissue toxicity. The most prevalent thoracic toxicity is radiation pneumonitis. In order to …
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An Adaptive Dose Finding Design (DOSEFIND) Using A Nonlinear Dose Response Model
… trials are the first time that an NCE is dosed in human subjects, the designs used in these trials are unique and geared toward patient safety. We develop a method for obtaining the desired response using an adaptive non-linear approach. This method is applicable for studies in which MTD, …
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Dose-Response Association Between Acute Exercise Duration, Exercise Recovery and Cognitive Function
Previous studies have shown moderate intensity exercise to be a desired intensity level to optimize cognitive function, however, this research has mostly been conducted among older adults despite the claim that cognitive function may start to decline in the early years (i.e., 20s). Another research …
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Efficient Design Of Biological Experiments For Dose-Response Modeling In Nanomaterial Toxicology Studies
… proposed design method adopts suitable nonlinear dose response curve and non-constant variance model in experimental modeling, which more adequately represents the desirable properties of bioassay-experiment. A multiple objective genetic algorithm were used to select best set of non-dominated …
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Development of CPAP Dose Response for Patients with Obstructive Sleep Apnea: Secondary Analysis
… to be arbitrary. We aimed to characterize a CPAP dose response for short term outcomes, including sleepiness severity and quality of life. Methods We performed secondary analysis on a prospective, observational cohort study of adult patients (≥18 years old) with newly diagnosed OSA (no CPAP, …
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Dose-Response Effects of Lithium on Spatial Memory in the Black Molly Fish.
… animal model, the black molly fish, to study dose-response effects of lithium on short-term (STM) and long-term (LTM) memories. We developed a method utilizing capillary ion analysis (CIA), to measure plasma and brain lithium levels employed in our behavioral studies. We then developed an …
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Dose-Response Effects of Working Memory Training Among Adolescents with Type 1 Diabetes
… measures and treatment adherence would have a dose-dependent relationship with n-back training. However, no association was found between training dosage and EF outcomes or treatment adherence. The study’s limitations include a relatively small sample size along with low participant compliance …
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Improving Dose-Response Correlations For Locally Advanced Nsclc Patients Treated With Imrt Or Pspt
… patients remains below 28 months. Higher tumor dose has been found to increase survival but also a higher rate of radiation pneumonitis (RP) that affects breathing capability. In fear of such toxicity, less-aggressive treatment plans are often clinically preferred, leading to metastasis and …
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Training load monitoring in soccer : the dose-response relationships with fitness, recovery and fatigue
… determine the magnitude of the physiological responses on an individual basis. Therefore the major aim of this thesis was to examine the dose-response relationships between measures of training load and the physiological and biochemical responses used as markers of recovery from match-play. …
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The relative dose response to a small oral dose of vitamin A in cystic fibrosis
Thesis: M.S., Massachusetts Institute of Technology, Department of Nutrition and Food Science, 1980
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Novel Approaches to Exposure Assessment and Dose Response to Contaminants in Drinking Water and Food
… novel methods for exposure assessments and dose responses to contaminants in drinking water and foods. Factors that greatly impact contaminant exposures and human dose response include: population susceptibility (i.e., healthy adults or children), different routes of exposures (i.e., …
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The Dose Response Effect of Almonds on Serum Vitamin E, Plasma Lipid Fractions and Erythrocyte Phospholipids
… consuming the low and high almond group, and a dose response effect was found. A 1 % increase of energy from almonds resulted in a 0.5μmol/L increase in α-tocopherol in plasma and a 0.005μmol/L increase in red blood cells in subjects that did not take vitamin E supplements prior to the study. …
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A Bayesian Approach to Dose-Response Assessment and Drug-Drug Interaction Analysis: Application to In Vitro Studies
… and minimizing or delaying drug resistance. Dose-response assessment and drug-drug interaction analysis play an important part in the drug discovery process, however analysis are often poorly done. This dissertation is an effort to notably improve dose-response assessment and drug-drug …
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Urinary phthalate exposure and reproductive outcomes in U.S. women: evidence of dose-response associations in NHANES 2003-2014
Phthalates are a group of endocrine-disrupting chemicals widely used in consumer products and consistently detected in human populations. Although experimental studies suggest that phthalate exposure may affect reproductive function, evidence in women at the population level remains limited and not …
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Benefits of Quercetin on Metabolic and Inflammatory Biomarkers in High Fat Diet Induced Obesity: A Dose Response Study
… We examined the effects of three different doses (0.02%, 0.2% & 2%) of quercetin on obesity markers, macrophage populations, and inflammatory mediators in a mouse model of high fat diet induced obesity. Our high fat diet treatment was 16 weeks and based on the American Standard Diet that …
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Penalized spline modeling of the ex-vivo assays dose-response curves and the HIV-infected patients' bodyweight change
… The first part discusses the modeling of the dose-response relationship with correlated data by introducing overall drug effects in addition to the deviation of each subject-specific curve from the population average. Here, a penalized spline regression method that allows modeling of the …
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A Dose -Response Investigation of Patterns and Correlates of Affective Responses to Acute Exercise: The Dual -Mode Hypothesis
"Affective responses to single bouts of exercise are likely to influence the long-term adherence to exercise programs. It is, therefore, important from a public health perspective to understand the factors that influence these affective responses. One factor that has received relatively little …
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