Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"dose optimization"”.
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Radiation dose optimization in interventional radiology and cardiology using diagnostic reference levels
… optimize their radiation usage using DRLs. The Dose Area Product (DAP) quantity measured for each patient represents a dosimetry index, the value of which for the purpose of improvement should be optimized against the DRL. In this dissertation, I aim to establish if DRLs in the South African …
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Population pharmacokinetic modelling for dose optimization of esomeprazole to treat early-onset preeclampsia
… It was hypothesized that the 40 mg daily oral dose was not enough to achieve therapeutic exposure. This study investigated the pharmacokinetics of esomeprazole in patients with early- onset preeclampsia with the aim to optimize the dose for future clinical trials. Methods Pharmacokinetic data …
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Applications of Voronoi partitions in particle therapy
… in modern cancer management due to its increased dose to the targeted tumors and improved sparing of surrounding normal tissues and critical structures. Many challenging and interesting mathematical optimization problems arise in the planning of charged particle radiation therapy. In this thesis, …
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Antimicrobial Susceptibility of Listeria monocytogenes to Bacteriophage LISTEX™ P100 in Alfalfa Sprouts (Medicago sativa)
… illnesses, factors such as phage delivery and dose optimization in sprouts need to be further investigated.</p>
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Optimizing Laser and Liquid Nitrogen Treatments for Weed Control in Turfgrass Systems
… applicator was used to deliver precise doses of liquid nitrogen (LN) to individual plants of goosegrass (Eleusine indica) and annual bluegrass (Poa annua). Four field trials were conducted across two sites in Blacksburg, VA, testing seven LN doses (0–5.1 mL). LN reduced green cover …
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Nonlinear mixed-effects modelling of drug-drug interactions between antiretroviral therapy and tuberculosis treatment
… Our pharmacokinetic model of standard- and high-dose rifampicin in PWH identified lower bioavailability of the top-up capsule formulation as the cause of lower-than-expected drug exposures in participants on high-dose rifampicin. Furthermore, the reduced dolutegravir exposures in participants on …
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A scoping review on the use of telerehabilitation in physiotherapy in low and middle income countries
… drug, administered as part of a fixed-dose combination regimen for the treatment of tuberculosis (TB). Individuals with comorbid HIV have reported reduced serum concentrations of ethambutol. We aimed to evaluate the pharmacokinetics of ethambutol in individuals with both …
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Optimising therapeutic strategies for chronic rhinosinusitis
… poor awareness of treatment optimization options, and trivialization of symptoms by patients and physicians. Characteristically, these factors contribute to a typical remitting and relapsing disease course. The objectives of this work are to improve the therapeutic index and …
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Convex and Robust Optimization Methods for Modality Selection in External Beam Radiotherapy
… tumor while limiting toxic effects of radiation dose on the organs-at-risk (OAR). EBRT can be delivered via different modalities such as photons, protons, and neutrons. The choice of an optimal modality depends on the anatomy of the irradiated area, and the relative physical and biological …
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Innovative Methods for the Design and Analysis of Phase II Clinical Trials
… key challenges in phase II trials in terms of dose-ranging study, patient population selection, and decentralized clinical trials (DCTs). This dissertation presents a comprehensive set of methodologies that address these critical issues with three projects. The first project introduces a …
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Ein effektiver und verlässlicher Ansatz zur Reduktion der Strahlenexposition des medizinischen Personals im Kontext der Radiojodtherapie
Die Validierung der Aktivität der Jod-131-Kapseln vor der Radiojodtherapie ist gesetzlich vorgeschrieben. Die Anwendung des dargestellten alternativen Messverfahrens führt zu einer erheblichen Reduktion der Strahlenbelastung des medizinischen Personals und insbesondere der Hände. Es ermöglicht eine …