Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"dose enhancement"”.
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Effective dose enhancement using gold as a radiation sensitizer: a Monte Carlo study
… to dramatically increase the amount of effective dose received by the tumor without increasing the amount received by the surrounding healthy tissue. Several contrast materials have been explored for this application with iodine and gadolinium receiving generating significant interest. Following …
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Radiation Dosimetry in the Presence of Gold Nanoparticles
… use of gold nanoparticles (GNPs) to enhance the dose due to radiation, through increased photoelectric effect interactions, has shown promise in vivo and in vitro. Monte Carlo studies have worked towards quantifying the dose enhancement and the dosimetry surrounding GNPs. This thesis investigates …
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Nanoparticles for Simultaneous Assessment of Ros and Radiosensitization of Brain Cancer Cells for Improved Radiotherapy Outcomes
… cancerous tumour. Nanoparticle Mediated Dose Enhancement of Radiation Therapy is emerging as a favourable modality for enhancing radiotherapeutic ratio through local tumour dose enhancement and radiosensitization. This is due to the ability of specific nanoparticles (NPs) to increase …
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Measurement of The Electron Return Effect Using Presage Dosimeter
… as superior soft tissue contrast, no imaging dose, and functional imaging capacities, but it also has concerns to be addressed. The electron return effect (ERE) refers to dose enhancement at the interface between different media, caused when radiation is delivered in the magnetic field. The …
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Design of an Ytterbium-169 brachytherapy source for gold nanoparticle-aided radiation therapy
… Ytterbium-169 is a strong candidate for a high dose rate brachytherapy implementation of gold nanoparticle-aided radiation therapy. Therefore, the current study focuses on the design of a high dose rate Ytterbium-169 source that would maximize dose enhancement during gold nanoparticle-aided …
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Macrophage regulation of T lymphocyte subsets in normal and tumor- bearing hosts
… and TBH Lyt-1⁺ T cells were inhibited by high doses of normal or TBH MΦ culture supernatants. This inhibition could be removed by dilution of the MΦ supernatants. TBH MΦ culture supernatants exhibited high dose inhibition and low dose enhancement of slowly proliferating normal and TBH Lyt-2⁺ T …
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Inactivation synergy between high energy neutrons and ⁶⁰Co gamma rays
… quantified in terms of molecular yield per unit dose absorbed in a ferrous sulphate xylenol orange solution and was found to vary inversely with the mean LET of the radiation field. Inactivation parameters determined for mammalian and meristematic cells were not significantly different following …
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Nuclear-Targeted Gold Nanoparticles Enhance The Effects of Radiation Therapy With and Without Liposomal Delivery
… administrations of AuNPs prior to each radiation dose during a course of fractionated radiotherapy. To overcome these challenges, the next generation of AuNPs should be engineered with 2 design criteria: compatibility with multiple radiation platforms, and appropriate <em>in …
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Accelerator-Based Neutron Branchytherapy
… tumors which limits the diameter of the dose delivery needle tube to 6 mm. A prototype needle tube, a tube-in-tube design with cooling water running in between the inner and outer tubes to cool the beryllium target located at the tip of the inner tube, has been tested to a heat load near …
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Reduction of Dose Calculation Errors For Patients With Metal Implants Receiving Photon Radiation Therapy
… these metal implants can degrade the accuracy of dose calculations. Dose calculation errors result from limitations of modern dose calculation algorithms in modeling metal/tissue interface effects. Metals also cause streak artifacts in the computed tomography (CT) images that are used for …
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A Monte Carlo-based Model Of Gold Nanoparticle Radiosensitization
… within the therapeutic window - delivering doses of ionizing radiation to achieve locoregional tumour control, while minimizing normal tissue toxicity. A greater therapeutic ratio can be achieved by utilizing radiosensitizing agents designed to enhance the effects of radiation at the tumour. …