Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 4459 for “"dose"”.
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An Adaptive Dose Finding Design (DOSEFIND) Using A Nonlinear Dose Response Model
… trials are the first time that an NCE is dosed in human subjects, the designs used in these trials are unique and geared toward patient safety. We develop a method for obtaining the desired response using an adaptive non-linear approach. This method is applicable for studies in which MTD, …
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Dose Calculation For Electron Therapy
<p>The dose delivered by electron beams has a complex dependence on the shape of the field; any field shaping shields, design of collimator systems, and energy of the beam. This complicated dependence is due to multiple scattering of the electron beam as the beam travels from the accelerator head …
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Dose-banding studies on oxaliplatin
… This thesis evaluates whether a specific dose-banding scheme for oxaliplatin could replace the individual dosing method that is currently used in the oxaliplatin administration. Dose-banding was introduced into UK clinical practice in 2001, as it reduces delays in patients receiving their …
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Contributions to Clinical Dose Individualisation
… and prevention of many diseases. Tailoring dose size and frequency to achieve a therapeutic target that meets the needs of an individual patient is a fundamental objective of treatment. Pharmacokinetic-pharmacodynamic models allow for the dose-concentration-effect relationship, and …
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The relative dose response to a small oral dose of vitamin A in cystic fibrosis
Thesis: M.S., Massachusetts Institute of Technology, Department of Nutrition and Food Science, 1980
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Effect of dose and dose rate on benzo[a]pyrene induced mutational spectra in human cells
Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Civil Engineering, 1994.
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14 MeV neutron generator dose modeling
Modeling and understanding the doses around the neutron generator provides insightful data in regard to radiation safety and protection precautions. Published data can be used to predict doses, but realistic data for the Nuclear Engineering Teaching Laboratory’s Thermo MP 320 Neutron Generator …
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Dose reduction of biologics in psoriasis
Contains fulltext : 240236.pdf (Publisher’s version ) (Open Access)
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Clarithromycin nanocrystals for high-dose inhalation
… / i.v. antibiotics often require high systemic doses to reach effective lung levels, increasing adverse effects, lowering adherence and fostering resistance. This work developed a high-dose inhalable dry-powder approach to deliver clarithromycin locally. Poorly soluble clarithromycin (BCS II) …
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A systematic review and meta-analysis of fractional dose compared to standard dose inactivated polio vaccination in children
… the introduction of at least one single dose of inactivated polio vaccine (IPV) in routine immunisation schedules to mitigate the risk of a polio virus type 2 reintroduction or re-emergence. As a result, there has been an increased demand and concurrent supply shortages of IPV worldwide …
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Characterizing canine dose from external beam irradiation
Absorbed dose from Computed Tomography (CT) is a major concern on an individual basis as well as for the collective population due to increased frequency of and dependency on CT scans for diagnostic and therapeutic imaging. Colorado State University recently integrated a large bore multi-slice …
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Radiation dose assessment : measurement, estimation and interpretation
… are often accompanied with additional radiation dose yet this can be justified through the consideration of the benefit it brings. Examples include the use of CT colonography instead of double contrast barium enemas, CT urography replacing intravenous urography and, in nuclear medicine imaging …
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Discrete ordinates CT organ dose simulator (DOCTORS)
… CT has raised concerns regarding long term low-dose radiological risks.</p><p>Currently, the dose to patients is computed using Monte Carlo methods and experimental tests. In other areas of radiation transport, deterministic codes have been shown to be much faster than Monte Carlo …
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Adaptive designs for complex dose finding studies
… phase clinical trial is to find the regimen (dose, combination, schedule, etc.) satisfying particular toxicity or (and) efficacy characteristics. Designs for trials studying doses of a single cytotoxic drug are based on the fundamental assumption "the more the better", that is, the toxicity …
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Epigenetic Response to Low-Dose Ionizing Radiation
<p>Low-dose ionizing radiation (LDIR) exposure (under 10.0 centigray (cGy)) from man-made sources, such as diagnostic imaging, predominates in the US population and comprises nearly 50% of an average individual's yearly radiation exposure (Ullrich, Brooks et al. 2009). The increase in such …
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Radiation dose to the global flying population
… Previous studies have assessed the radiation dose received in particular cases or for cohort studies. Here we present the first estimate of the total radiation dose received by the worldwide civilian flying population. We simulated flights globally from 2000 to 2013 using schedule data, …
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The pharmacokinetics of single oral dose extended-release topiramate and adverse effects after multi-dose administration in healthy cats
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01
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