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Showing 1 to 20 of 20 for “"dosage compensation"”.
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Targeting the dosage compensation complex to the chromosome in Drosophila melanogaster
Contains fulltext : 65589_targthdoc.pdf (Publisher’s version ) (Open Access) Contains fulltext : 72554.pdf (Publisher’s version ) (Open Access)
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Rox1 function in dosage compensation: structural / functional analysis of a non-coding rna
… gene regulation that occurs during dosage compensation in Drosophila. Dosage compensation in Drosophila melanogaster occurs by a global two-fold increase of transcription from the single male X chromosome. This essential process compensates for X chromosome monosomy. The …
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Investigation Of X Chromosome Recognition: The Role Of Small Rna In Drosophila Dosage Compensation
… is critical for survival. This process is termed dosage compensation. Flies increase expression from the male X chromosome two-fold. This is achieved by the Male Specific Lethal (MSL) complex, which consists of two large, non-coding RNA on the X transcripts (<i>roX1</i> and <i>roX2</i>) and five …
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Investigation of the roX RNAs and the RNA Helicase MLE in Dosage Compensation in Drosophila melanogaster
… where males are XY and females are XX, dosage compensation is acheived by approximately two-fold upregulation of transcription of the single male X chromosome. This upregulation is mediated by the dosage compensation complex (DCC), which is assembled in a sequential manner on the male X …
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DNA Replication of the Male X Chromosome Is Influenced by the Dosage Compensation Complex in Drosophila melanogaster
… on the X chromosome in males is a consequence of dosage compensation in D. melanogaster. Like many organisms, D. melanogaster females have two X chromosomes while males have one. To compensate for this difference, males upregulate the genes on the X chromosome two-fold. This upregulation is …
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The Mechanism Of Regulation Of Autosomal Heterochromatic Genes In drosophila Melanogaster Males By rox Rna And Msl Proteins
… gene expression. To equalize X-linked gene dosage between sexes, both humans and flies developed independent strategies which are called dosage compensation. Human females randomly inactivate one of their X chromosome into barr body and <i>Drosophila</i> males up regulate their single X …
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Genomics and Transcriptomics Analysis of the Asian Malaria Mosquito Anopheles stephensi
… we demonstrated the presence of complete dosage compensation in An. stephensi by determining that autosomal and X-linked genes have very similar levels of expression in both males and females. The uniformity of average expression levels of autosomal and X-linked genes remained when An. …
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Studies on the mechanisms of action of the male specific lethal complex in Drosophila
… THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Dosage compensation is achieved by a twofold up-regulation of the single X chromosome in male Drosophila. The inverse dosage effect produced by the single dose of the X chromosome increases the expression of the X chromosome and autosomes. In order …
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Sex And Heterochromatin: An Investigation Of Sexual Dimorphism In Drosophila Melanogaster
… Lethal (MSL) proteins, all components of the dosage compensation complex, are required for full expression of autosomal heterochromatic genes in male flies but not in females. This was surprising since heterochromatin is generally not thought to be sexually dimorphic. The genetic basis for the …
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Sex chromosome evolution of papaya: Dynamic structural and expression changes and identification of associated traits
… in hermaphrodites and in all flower tissue. Dosage compensation is a phenomenon utilized by many organisms with sex chromosomes to account for the heterogametic sex having only one allele for many of the genes on the sex chromosome. While many organisms compensate expression levels in the …
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Autosomal random asynchronous replication is analogous to X-chromosome inactivation
… of random X-chromosome inactivation, the dosage compensation machinery in mammals. We have shown that autosomal coordination responds to trisomy in a fashion similar to X inactivation, with one copy of the trisomic chromosome marked for early replication and the other two rendered late …
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Aneuploidy reveals insights into control of protein complex stoichiometry
… aneuploidy simultaneously alters the gene dosage of hundreds to thousands of genes. The outcome is an imbalanced proteome, which has a negative impact on cellular physiology and places intense demand on the protein quality control system of the cell to effectively fold and/or degrade …
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Mutational analysis of JIL-1, a tandem kinase in Drosophila
… polytene chromosome morphology maintenance, dosage compensation pathways, and homeotic transformation pathways. Due to the limitation of deletion/insertion mutations, EMS mutagenesis was performed to induce point mutations of JIL-1 and the mutation screen was designed to recover …
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Histone modification and the epigenetics of X chromosome inactivation
Dosage compensation serves to equalise the levels of X-linked gene products between males and females. In mammals this occurs through the transcriptional silencing of the majority of the genes on one of the two female X chromosomes. The inactive X chromosome (Xi) differs from its active homologue …
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Adaptive evolution, sex-linkage, and gene conversion in the voltage-gated sodium channels of toxic newts and their snake predators
… of these sex-linked sodium channel genes are dosage compensated in embryos, adult muscle, and adult brain. In contrast, two channels show sexual dimorphism in their expression levels in the heart, which may indicate differences in dosage compensation among tissues. I then use comparative …
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Genomic characterization and comparative analysis of the Xce candidate region
<p>Mechanisms of sex chromosome dosage compensation vary widely between different vertebrate species. All eutherians, including humans, other primates, and rodents, undergo random X chromosome inactivation in early female embryos, a process by which the majority of the genes on one X chromosome in …
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RNA in the nucleus: insight into location and biological function
… biogenesis, regulation of gene expression, and dosage compensation. Currently used technologies to study RNA chromatin interactions pull down individual RNAs and sequence the associated DNA. However, it remains challenging to identify chromatin associated RNAs and their genomic target sites. In …
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The effects of aneuploidy on gene expression in a dosage series of maize chromosome arm 1L /
… conditions necessarily involve a change in the dosage of those genes which are located on the varied chromosome. However, the dosage level of a gene does not automatically correspond to the amount of RNA or protein that will be produced in vivo. Based on previously published studies, the impact …
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RNA Helicase 1 interacts with an ABCRNAi Transporter: Genetic Interactions with haf-6
… gene(MLE), an essential component of the dosage compensation machinery that leads to a two-fold increase in transcription of genes located on the single X chromosome of males in comparison to the transcription rate of homologous genes located on an X chromosome in females. The human …