Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 32 for “"dorsal striatum"”.
-
The influence of anesthesia and nicotine on dopamine signaling in the rat dorsal striatum
<p>The striatum is highly innervated by dopamine neurons and is involved in movement control (dorsal striatum) reward learning (ventral striatum). Fast-scan cyclic voltammetry (FSCV) is a technique that uses microelectrodes (diameter ~5 μm, length ~150 μm) to monitor dopamine signaling in the …
-
EFFECTS OF REPEATED ARIPIPRAZOLE TREATMENT ON THE cAMP AND AKT PATHWAYS IN THE DORSAL STRIATUM OF PREADOLESCENT AND ADULT RATS
… from an excess of D2-like receptors in the dorsal striatum. In order to examine the effects of repeated antipsychotic treatment on dopamine system functioning, this thesis compared the molecular effects of repeated haloperidol and aripiprazole administration on D2<sup>High </sup>receptors, …
-
Multiple Memory Systems in People With Schizophrenia: Possible Effect of Atypical Anti-Psychotic Medications
… the areas of the brain they affect including the dorsal striatum, a subcortical section of the forebrain, and the prefrontal cortex (PFC), located in the anterior part of the frontal lobes. Two different tests of implicit memory, the probabilistic classification learning (PCL) and the Iowa …
-
Effects of dopamine depletion in the nucleus accumbens on lateral hypothalamic self-stimulation in the rat
… destruction of dopaminergic projections to the dorsal striatum. In contrast, the changes in reward have been linked to changes in the dopaminergic input to the nucleus accumbens (NAcc). We reexamined the effects of dopamine depletion induced by 6-hydroxydopamine (6-OHDA) on lateral hypothalamic …
-
Haloperidol-Environment Interaction Modulates Expression of c-Fos Proteins in the Basal Ganglia in Rats
… showed evidence of lower c-Fos levels in the dorsal striatum and nucleus accumbens shell, possibly a result of daily haloperidol injections. No group differences in c-Fos expression were found in the piriform cortex, ventral hippocampus, ventral tegmental area or lateral habenula. The numbers …
-
Prostaglandin-Mediated Reinstatement of Drug Taking After Alcohol Drinking by Female Adolescent Rats
… alcohol drinking also had increased COX-2 in the dorsal striatum, regardless of subsequent Meth selfadministration. These findings demonstrate that a history of adolescent alcohol drinking does not alter Meth self-administration but persistently reduces cue-primed Meth seeking and increases COX-2 …
-
Striatal Microcircuits Underlying Control of Actions
<p>The striatum is the input nucleus of basal ganglia, a group of subcortical nuclei that includes the striatum, globus pallidus, subthalamic nucleus, and substantia nigra. These brain regions have been implicated in control and coordination of motor planning and action selection. Especially, the …
-
The Impact of Methylenetetrahydrofolate Reductase (MTHFR) Deficiency in a Paraquat Mouse Model of Parkinson’s Disease
… antioxidant activity were observed within the dorsal striatum of Mthfr+/- mice. These results suggest potential enhanced vulnerability to paraquat due to MTHFR deficiency through changes in such processes within this region.
-
The Effect Of An Intermittent Manganese (ii) Exposure On The Striatal Dopamine System
… excess Mn exposure on the dopamine system in the dorsal striatum, the following methods were used: ex vivo tissue content, in vitro fast scan cyclic voltammetry, in vivo microdialysis, and graphite furnace atomic absorption spectroscopy. The results demonstrate a bi-phasic striatal DA response …
-
EXAMINING THE NEUROBIOLOGY OF NON-SUICIDAL SELF-INJURY IN CHILDREN AND ADOLESCENTS: THE ROLE OF REWARD RESPONSIVITY
… between regions of interest (ROIs; ventral and dorsal striatum [VS, DS], anterior cingulate cortex [ACC], orbitofrontal cortex [OFC], ventrolateral and ventromedial prefrontal cortex [vlPFC; vmPFC], and insula) and whole-brain connectivity (utilizing bilateral DS, mPFC, and insula seed ROIs) in …
-
Estrogenic modulation of place and response learning via specific receptor-mediated mechanisms
… but impair the performance of tasks that tap the dorsal striatum. These memory systems do not act in isolation but rather appear to interact extensively when an animal attempts to learn a given task, with estrogens acting to shift the relative contributions of each neural structure for the …
-
Functional organisation of behavioural inhibitory control mechanisms in cortico-basal ganglia circuitry: implications for stimulant use disorder.
… with the control group. In contrast, the ventral striatum was linked to incentive specific activation to reward anticipation. Task-based fMRI demonstrated that interactions between dorsal striatum and cingulo-opercular “cold cognition” networks underlie failures of impulse control in the control, …
-
Selective memory impairments produced by transient lidocaine-induced lesions of the nucleus accumbens
… lesions, but is disrupted by lesions in the dorsal striatum. The present study utilized these two procedures, along with reversible lidocaine-induced lesions of the N.Acc., to determine whether the N.Acc. is part of the extra-hippocampal system that subserves efficient memory-based foraging …
-
Separating Within-trial Activities in the Stop Signal Task Using fMRI
… richly innervated by midbrain dopamine neurons (dorsal striatum and ventral anterior cingulate cortex (ACC)), followed by deactivations during post-error adjustment in structures that modulate the ascending dopamine response (ventral striatum and caudal orbitofrontal cortex), which encode error …
-
The Role of CLOCK in Regulation of Dopamine Neurotransmission in the CLOCKdelta19 Mutant Mouse Model
… dopamine and metabolites were performed in the dorsal striatum revealing significant increases in DOPAC and HVA. Dopamine receptor agonists and antagonists were used to pharmacologically probe dopamine receptor function. An enhancement of the locomotor suppressing response to dopamine …
-
The role of frontal cortical-basal ganglia circuits in simple and sequential visuomotor learning
… to elucidate the role of frontal cortex and striatum in visuomotor learning. Several tasks were used to characterize motor function including: a visuomotor reaction time (VSRT) task, measuring response speed and accuracy to luminance cues; simple stimulus-response (S-R) learning, measuring …
-
Examining cholinergic fuction in the ventral tegmental area and dorsal hippocampus
… (VTA) to the prefrontal cortex (PFC) and ventral striatum (NAc and OT) forming a key part of the well-defined mesocorticolimbic system, as well as the hippocampal-VTA loop. The mesocorticolimbic system, at least partly, mediates the rewarding effects of drugs of abuse, such as nicotine. The VTA …
-
The Effects of Nicotine Administration on Behavior and Markers of Brain Plasticity in a Rodent Model of Psychosis
… were dissected and the nucleus accumbens and dorsal striatum were analyzed for brain-derived neurotrophic factor (BDNF), phosphorylated cAMP response element binding protein (pCREB), and glial-cell derived neurotrophic factor (GDNF), all proteins involved in neuronal plasticity. Results: …
-
Adenosine monophosphate-activated protein kinase regulates reward regions of the brain during cocaine sensitization
… AMPK phosphorylation decreased in the dorsal striatum and increased in the prefrontal cortex, though only broad brain regions were investigated. Subregions of the prefrontal cortex, the prelimbic and infralimbic cortices, differentially regulate reward signaling. For example, the …
Page 1 of 2