Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"dorsal root ganglia"”.
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A microfluidic culture for two populations of dorsal root ganglia for differential staining
… to visibly distinguish the two populations of dorsal root ganglia (DRGs) by differential staining. Polydimethylsiloxane (PDMS) is the most widely used silicon-based organic polymer, and is particularly known for its wide spread use in microfluidics. Various methods have been employed to pump …
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Characterization of neural progenitor cells of the embryonic and adult dorsal root ganglia
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Neurochemical characterization of the rodent primary sensory system
… the full content of peptides within the dorsal root ganglia, which houses the cell bodies of the primary sensory neurons, as well as other related tissues of rat and to detect changes in the peptide content of the dorsal root ganglia and dorsal horn upon generation of an itch model in …
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UCHLI in the Mammalian Nervous System
… of UCHLO1 in brain, spinal cord, and lumbar dorsal root ganglia, described degeneration of muscle spindles, and established a timecourse of degeneration of neuromuscular junctions. Presented in this thesis is the culmination of these studies.
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The Expression of Copper Transporters in Rat Dorsal Root Ganglion Neurons and its role in Oxaliplatin Neurotoxicity
… is associated with peripheral neuropathy and dorsal root ganglia neurons are the putative target, however the mechanism of toxicity is currently unknown. Recent evidence suggests that copper transporters may be implemented in the transport and neurotoxicity of platinum drugs. We hypothesis …
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Role of Cyclooxygenase Isoforms in Peripheral Neuropathic Pain Model
… The ligation of L5 spinal nerve entering the dorsal root ganglia developed mechanical hyperalgesia within 1 day, and showed similar symptoms as in human with neuropathic pain. We investigated whether COX isoforms, rate-limiting enzymes that synthesize the prostaglandins, were involved in the …
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Opto-mechanical control of nerve growth
… than commonly used electrical stimulation. Using dorsal root ganglia (DRGs) expressing channelrhodopsin 2 (ChR2) as a test system, I have investigated a broad range of optical stimulation parameters and identified conditions that enhance neurite outgrowth by three-fold as compared to unstimulated …
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Identification and characterization of a novel neurotrophic factor secreted by a mouse Schwann cell line
… nor did it have survival effects on 1-day-old dorsal root ganglia or E13 spinal cord culture. Thus, we conclude that the trophic factor in MCM is a novel and specific survival factor for dopaminergic neurons.
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Magnetothermal Modulation of Nerve Growth
… wireless, magnetothermal modulation of dorsal root ganglia (DRG) explants, sensory neuronal structures that are a critical target for nerve therapy. Calcium influx into neurons plays a key role in many processes necessary for axonal regeneratiton. Using magnetothermal modulation, we …
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The extraction of type 1 collagen and the fabrication of multi-filament embedded hydrogels for guided nerve regeneration
… on 2D and 3D environments revealed that dorsal root ganglia (DRGs) slightly favored 3D collagen gels compared to 2D collagen substrates after 9 days of culture. DRG neurites grown on 3D collagen gels exhibited optimal growth on a 0.8 mg/ml collagen gel concentration. Extracted type I …
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Glia-neuron signaling
… and aspartate, from glial cultures obtained from dorsal root ganglia (DRG) together with an increase in the cytoplasmic level of glial free calcium. Perturbations which inhibited bradykinin-induced calcium mobilization prevented the release of EAAs from glia. The addition of ionomycin caused a …
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Restoring bladder function by promoting neuronal regeneration
Following dorsal root injury, dorsal root ganglion neurons can regenerate their severed axons but are unable to cross the dorsal root entry zone (DREZ) due to the presence of an inhibitory environment produced in part by chondroitin sulfate proteoglycans (CSPGs) manufactured by reactive astrocytes …
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Group III mGluR8 negatively modulates TRP channels
… axons and is co-localized with TRPV1 in the dorsal root ganglia (DRG). In behavior studies, peripheral activation of group III mGluRs had no effect on paw withdrawal latency (PWL) to heat in naïve rats. However, local peripheral activation of group III mGluRs significantly attenuated …
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Investigating intrathecal adeno-associated virus vectors for the study of analgesic interactions at the spinal level
… of primary afferent sensory neurons residing in dorsal root ganglia (DRG). Inhibition of pain signals directly at the spinal level provides an opportunity to reduce pain at the most basic level. Several G protein-coupled receptors, including opioid and adrenergic receptors, are known to be potent …
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Stabilization of the Cardiac Nervous System During Cardiac Stress Induces Cardioprotection
… the MI-induced activation of both nodose and dorsal root ganglia cardiac-related afferents, doing so without antidromic activation of the primary cardiac afferents. Instead, thoracic SCS acts through altering the cardiac milieu thereby secondarily affecting the primary afferent sensory …
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Non-Psychotropic cannabinoids attenuate visceral pain in colitis
… marker c-Fos in neurons of the lumbosacral dorsal horn. A single injection intraperitoneal injection of 10 mg/kg of either CBD or CBG was found to reduce both nocifensive behaviors in the functional assay and c-Fos activity in spinal cord in animals with colitis. Similarly, a combination of …
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Ubiquitin Targets and Molecular Mechanisms of Herpes Simplex Virus 1 Infection in Adult Sensory Neurons
… We utilized primary adult sensory neurons of the dorsal root ganglia and HSV-1 viral strains KOS, wild-type virus encoding a fully functional ICP0, and HSV-1 n212, encoding a truncated ICP0 protein, to illuminate the mechanisms involved in establishing and maintaining HSV latency. By using adult …
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Sensory Neurogenesis and the Role of PRDM12 in Nociceptor Development and Function
… neurons, with an as-yet unknown role in dorsal root ganglia. Altogether my work highlights the role of Prdm12 in nociceptor development and lays the groundwork for additional studies to investigate the clinical relevance of this gene.
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Trpv1 Channels Contribute to Behavioral Hypersensitivity and Spontaneous Activity In Nociceptors After Spinal Cord Injury
… vanilloid 1 (TRPV1) has been observed in the dorsal horn of the spinal cord after SCI, and reduction of SCI-induced hyperalgesia by a TRPV1 antagonist has been claimed. However, the possibility that SCI enhances TRPV1 expression and function in nociceptors has not been tested. I produced …
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