Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"dorsal raphe"”.
-
Regulation of dorsal raphe serotonergic neurons by histamine
… structures. Serotonergic neurons located in the dorsal raphe nucleus (DRN) are currently accepted to be wake-promoting however their precise regulation by other neurotransmitter systems during the sleep-wake cycle is currently unknown. The main aim of this study was to utilise in vitro and in …
-
Control of intertemporal choice by dorsal raphe serotonergic neurons
… future rewards is critical for survival. The dorsal raphe serotonergic neurons have been long implicated in the control of temporal discounting of reward [3] [4], but it is not clear whether their activities in fact direct the decision making process. In this thesis, I designed a cued …
-
The effects of intra-dorsal raphe administration of strychnine on rat behaviour and its interactions with ethanol
… serotonergic neurons which originate from the dorsal raphe nucleus. In addition, the serotonergic neurons of the dorsal raphe nucleus, which mediate the release of the neurotransmitter serotonin, have been implicated as a component of the neurocircuitry which underpins the generation of an …
-
The Effect of Electrical Stimulation of the Dorsal Raphe Nucleus on Local Cerebral Glucose Metabolism and Epileptogenesis in the Rat
<p>Anatomic connections between the dorsal raphé and the hippocampus have been described in the literature; however, the understanding of the functional importance of these connections is not complete. In these studies the "functional" raphé-hippocampal pathway was elucidated first by the …
-
Neuromedin U Acts via the Paraventricular Nucleus of the Hypothalamus and the Dorsal Raphe Nucleus to Regulate Motivation for High-Fat Food
… response to peripheral NMU indicated the PVN and dorsal raphe nucleus (DRN) as sites of action for NMU. NMU infusion into either region mimics the effects of peripheral NMU on food intake and operant responding for food. Moreover, NMUR2 knockdown in the PVN inhibited the incubation of craving-like …
-
Functional Dissection of Brainstem Circuitry
… this work describes the functional dissection of dorsal raphe cell types to elucidate their role in modulating survival functions. The second part outlines the development of a novel technology, Retro-TRAP, which we developed to address a critical, unmet need in neuroscience: molecular profiling …
-
Neural Computation Through Synaptic Dynamics in Serotonergic Networks
… network computations in the serotonergic dorsal raphe nucleus through a dynamical lens, exploring the role of short-term synaptic dynamics at sparse recurrent connections, and of distinct long-range synaptic inputs, in shaping the output of spiking populations. 1. Simulation-based …
-
Characterization of genetically distinct neuronal subtypes in the lateral habenula using Cre mouse lines
… projects to the ventral tegmental area (VTA) and dorsal raphe nucleus (DNR), and is thus involved in both dopaminergic and serotonergic pathways. Recent single-cell transcriptomic profiling of the LHb has revealed that it consists of four neuronal subtypes that are localized into four subregions. …
-
Targeted Disruption of the Deaf1 Gene in Mouse Brain and the Effects on Behavior and Gene Expression
… expression in the prefrontal cortex and the dorsal raphe nucleus of females but not males, and therefore may function in sex-specific depression. Standard (whole body) knockout of <italic>Deaf1</italic> has been reported to alter 5-hydroxytryptamine (serotonin) receptor 1A …
-
Pathological changes in mesostriatal neurons in a PKC-gamma mutant rat
… of the nigrostriatal dopaminergic (DA) and raphe striatal serotonergic (5-HT) systems. The movement impairments including rigidity of the hind limbs, a staggering gait, a tendency to fall over every few steps, a slight whole body tremor and difficulty in initiating movements. The dysfunction …
-
An analysis of behavioral and serotonergic mechanisms in male rat copulatory behavior
… elecrolytic lesions of either the median or dorsal raphe nuclei. While there were no significant differences among the groups on measures of copulatory or non-copulatory social behav- iors, a pattern of differences in those behaviors emerged which suggested that the serotonergic system may …
-
Intermittent swim stress effects on anxiety behavior
… and noradrenergic neurons were assessed at the dorsal raphe nucleus and locus coeruleus, respectively, through immunohistochemistry techniques. Results indicated ISS-induced deficits were noted for social exploration, but not with the open field test. No apparent cellular differences were …
-
Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation
… projections to the medial preoptic area (MPOA), dorsal raphe nucleus (DRN), and substantia nigra (SNR). Interestingly, transsynaptic retrograde tracing further demonstrated that these brain regions send projections to inguinal white adipose tissue (iWAT), suggesting potential ERαvlVMH-originated …
-
Using A Novel Optogenetic Approach To Directly Assess 5-Ht1a Somatodendritic Autoreceptor Function In Response To Chronic Selective Serotonin Reuptake Inhibitor Treatment
… autoinhibition in serotonergic neurons of the dorsal raphe nucleus (DRN). However, technical limitations have prevented direct testing of this hypothesis. In the current study we took advantage of optogenetic strategies to assess the effects of the classic SSRI fluoxetine on 5-HT1A …
-
Hormone Regulation of NPY Neuron Activity in the Arcuate Nucleus of the Hypothalamus
… regions including serotonergic neurons from the dorsal raphe. These inputs modify both long-term changes in gene transcription and acute changes in the electrical activity of these neurons, leading to a coordinated response to maintain energy and glucose homeostasis. While the regulation of …
-
CHRONIC LOW-LEVEL LEAD EXPOSURE AFFECTS THE MONOAMINERGIC SYSTEM IN THE MOUSE SUPERIOR OLIVARY COMPLEX
… innervation from the locus coeruleus and the dorsal raphe respectively. While the physiological role of the noradrenergic input has yet to be defined, serotonin is involved in auditory temporal processing. Because Pb exposure modulates auditory temporal processing, the serotonergic system is a …
-
CHRONIC LOW-LEVEL LEAD EXPOSURE AFFECTS THE MONOAMINERGIC SYSTEM IN THE MOUSE SUPERIOR OLIVARY COMPLEX
… innervation from the locus coeruleus and the dorsal raphe respectively. While the physiological role of the noradrenergic input has yet to be defined, serotonin is involved in auditory temporal processing. Because Pb exposure modulates auditory temporal processing, the serotonergic system is a …
-
Serotonergic Circuits Mediating Stress Potentiation of Addiction Risk
… conditioned place preference (CPP). Within the dorsal raphe nucleus (DRN), two overlapping populations of KOR-expressing neurons: Slc17a8 (VGluT3) and SERT, were distinguished functionally and anatomically. Optogenetic inhibition of these SERT+ neurons potentiated subsequent cocaine CPP, whereas …
-
Molecular Regulation of Opioid Receptor Signaling
… were used to show that KOR expression in the dorsal raphe is sufficient for KOR-mediated analgesia and aversion.
-
Stress, Monoamines, and Cognitive Flexibility
… coeruleus norepinephrine (LC-NE) system and the dorsal raphe-serotonin (DRN-5-HT) system. CRF actions on these systems may underlie cognitive symptoms of stress-related disorders. The age at which stress occurs can determine its impact, and adolescent stress has been linked to adult …
Page 1 of 2