Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"dorsal horn neurons"”.
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Encoding of periodic skin stimuli by spinal dorsal horn neurons
The encoding of vibrotactile pitch by neurons of the somatosensory system has been investigated at many levels of the neuraxis. These studies, however, have not extended to the spinal dorsal horn, which is known to process low threshold mechanoreceptive input. The studies presented here were …
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Mechanisms of rapid receptive field reorganization in rat spinal cord
… field (RF) reorganization of somatosensory neurons in the rat dorsal horn was examined using extracellular single unit recording. Subcutaneous injection of lidocaine into RFs of dorsal horn neurons results in expansion of their RFs within minutes. The expanded RFs appear adjacent to or/and …
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Reactive Oxygen Species and Lipid Peroxidation Products Contribute to Neuropathic Pain in Chronic Spinal Cord Injured Rats
… reactive oxygen species (ROS) generated in neurons as a result of spinal cord injury contribute to the chronic neuropathic pain measured in rats. When ROS was reduced in chronic SCI by using PBN, a ROS scavenger, there was a reduction in neuropathic pain behaviors and a reduction in …
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The role of Substance P and its signaling pathways in central sensitization
Central sensitization of nociceptive dorsal horn neurons is an underlying mechanism of behavioral phenotype, such as secondary hyperalgesia. Substance P (SP) is regarded as an important neuropeptide and mainly exists in primary afferent fibers in the superficial dorsal horn. Release of SP in the …
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Reactive oxygen species involvement in gabaergic dysfunction in neuropathic pain
… loss of inhibition by spinal GABAergic neurons and more importantly, the development of central sensitization—increased sensitivity of dorsal horn neurons to stimuli. Oxidative stress due to excessive levels of reactive oxygen species (ROS) has been implicated in the development and …
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A Study of Pro- and Anti-Nociceptive Factors In A Model of Colitis-Associated Visceral Pain
… and anti-nociceptive factors regulating colonic dorsal root ganglion (DRG) neurons, which synapse onto second order dorsal horn neurons, are known to regulate chronic pain but the mechanisms are poorly understood. This thesis examined whether neuroanatomical remodeling of DRG central nerve …
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Critical role of ROS in capsaicin-induced hyperalgesia
… in a dose dependent manner. MitoSox positive dorsal horn neuron numbers were increased significantly after capsaicin treatment. This study suggests that ROS mediates the development and maintenance of capsaicin-induced hyperalgesia in mice, mainly through central sensitization and the …
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Modulation of synaptic transmission by TRP channels
… make synaptic connections with second order neurons. Somatic and craniofacial afferents terminate in spinal cord dorsal horn (SDH) and caudal spinal trigeminal nucleus (CSTN). Neurotransmitter release from first order nerve terminals regulates ascending sensory transmission. Several lines of …