Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"dopaminergic system"”.
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Interactions of the Striatal Gene Rhes with the Dopaminergic System in Rodents
Mice that are incapable of expressing the small G protein Rhes have been generated and have shown to have abnormalities in behaviors mediated by the striatum, a region in which Rhes is highly expressed. Moreover, conditions that result in dopamine supersensitivity and a breakdown in D1/D2 synergism …
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Parkinson's disease and the influence of the forebrain dopaminergic system on dreaming
… by Solms (2000) to the effect that a forebrain dopaminergic mechanism is the final common path to dreaming. It was hypothesised that sufferers of Parkinson's disease (PO) would have decreased intensity and frequency of dreams - that is that PO disease may lead to cessation or reduced dreaming, …
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Alcohol-induced Locomotor Activity in Zebrafish is Mediated by Activation of the Dopaminergic System
… tolerance to alcohol's effect on locomotor and dopaminergic activity when continuously exposed to alcohol, highlighting the importance of the dopaminergic system. We correlated the alcohol-induced increase in dopamine levels with increased tyrosine hydroxylase activity and protein expression, …
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Interactions between the cholinergic and dopaminergic system during the production of ultrasonic vocalizations in rats
… into the ascending mesolimbic cholinergic system that terminates in the anterior hypothalamic-preoptic area (AH-MPO) and lateral septum (LS). The other group of USVs contains 50-kHz USVs, characterized by high peak frequency, ranging from 39 to 90-kHz, short duration ranging from 10-90 ms, …
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Methamphetamine-induced neuroadaptations in the rat: Effects of adolescent use on the dopaminergic system and drug taking behaviors
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-03-28 without embargo terms
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Alcohol-induced activation of the mesocorticolimbic dopaminergic system and its modulation by energy drinks and caffeine: neurochemical, behavioral, and immunohistochemical analysis
… on the responsivity of the mesocorticolimbic dopaminergic system, a neural circuit critically involved in reward processing and motivated behavior. During adolescence, this system is characterized by high vulnerability, which may lead to abnormal maturation in adulthood, resulting in …
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A study of the neuropharmacology and genetics of dopamine: using common, preclinical behavioral techniques, cognitive batteries, and genetic analyses to unravel the dopaminergic system
… behaviors. Through the use of animal models, the dopaminergic system has been implicated in several neuropsychiatric disorders. Furthermore, the application of genetic technologies has helped uncover how modulation of dopaminergic signaling leads to modification of normal behavior and contributes …
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A COMPARISON OF 2D IMAGE ANALYSIS AND DESIGN-BASED STEREOLOGY FOR EVALUATING MORPHOLOGICAL AND ANATOMICAL CHANGES IN THE DOPAMINERGIC SYSTEM OF THE RODENT MIDBRAIN
Background. 2D analyses produce systematic errors in quantifying anatomical and morphological features in the brain. Design-based stereology overcomes this limitation by applying probability theory, yet many neuroscience investigators still use 2D analyses. The purpose of this study is to compare …
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Tyrosine hydroxylase immunoreactive fibers in the upper layers of the adolescent rat medial prefrontal cortex
… of the medial prefrontal cortex by the dopaminergic system contributes to some of these maturing behaviors and the dopaminergic system is implicated in mental illnesses. However, much previous work on medial prefrontal cortex development over adolescence has considered only one sex or …
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Role of Dopamine Receptor 3 in Cardiac Fibrosis
… known to exist primarily in the central nervous system and have been extensively studied there. However, other organ systems in the periphery, such as the kidney, have been shown to express these receptors as well. Studies on dopamine receptors in the cardiovascular system are both lacking and …
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NEURAL BASIS OF PERFORMANCE EVALUATION IN BIRDS
… by representation of a key variable in the dopaminergic system, the reward prediction error. Yet most studies of the dopaminergic system have been in situations where an animal is motivated by external rewards, such as food or juice. Does RL apply to learning of complex behavior without …
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Serotonergic and dopaminergic systems as targets for exogenous neurotoxins causing a parkinsonian syndrome
… MPP⁺ had a higher inhibitory potency in the dopaminergic system, while MPTP had a higher inhibitory potency in the serotonergic system. Haloperidol metabolites (HPP⁺, R-HPP⁺, and HPTP) also inhibited both amine transport systems with a greater affinity for the serotonergic system. Additional …
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Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder
… and impulsivity and is theorised to be caused by dopaminergic dysregulation. Developmental stress interrupts vulnerable periods of neural developmental and has also been found to induce disturbances in dopamine. ADHD and developmental stress are both associated with a higher risk of abusing …
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Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΚΕΤΑΜΙΝΗΣ ΣΤΟ ΜΕΛΑΙΝΟΡΑΒΔΩΤΟ ΝΤΟΠΑΜΙΝΕΡΓΙΚΟ ΣΥΣΤΗΜΑ ΤΟΥ ΕΓΚΕΦΑΛΟΥ
… DAYS ONE OF THE FOLLOWING DRUGS THAT AFFECT THE DOPAMINERGIC TRANSMISSION. KETAMINE (20 MG/KG), AMPHETAMINE (2 MG/KG), APOMORPHINE (0,5 MG/KG), HALOPERIDOL (0,5 MG/KG), ATROPINE (1 MG/KG), AMPHETAMINE+KETAMINE, APOMORPHINE+KETAMINE, HALOPERIDOL +KETAMINE, ATROPINE+KETAMINE. KETAMINE AND …
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Investigation Of Dopamine Dynamics In Bdnf+/- Mice Using In Vivo Microdialysis And Electrochemical Analysis Of Purine And Monoamine Molecules Using A Boron-Doped Diamond Electrode
… in female mice lead to a dysregulation in their dopaminergic system. Through a series of <i>in vivo</i> microdialysis and slice voltammetry experiments, we have discerned that female BDNF<sup>+/-</sup> mice are hyperdopaminergic similar to their male BDNF<sup>+/-</sup> counterparts. The <i>in …
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Serotonergic modulation of cognition
… of two anatomically distinct decision-making systems, namely goal-directed and habitual behaviour. Goal-directed behaviour is characterized by the consideration of future choices and respective outcomes whereas habitual responding is driven by stimulus-response associations. Response …
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The role of Ubiquitin ligases Nedd4-1 and Nedd4-2 in the brain and their crosstalk with alpha-synuclein and other dementia-related proteins
… levels are increased in substantia nigra (SN) dopaminergic neurons, causing cell death. Current PD and DLB treatments are symptomatic and do not target the disease at its source or prevent its progression.<br/>In order to develop protective treatments for PD and DLB, it is important to first …
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MOTOR SEQUENCE LEARNING IN ADULTS WITH ADHD
"A healthy motor system is able to switch and adapt to different environmental contexts and select the most suitable strategy, thus maximizing the efficiency of the movements and save time or energy. Motor hyperactivity in individuals with ADHD is clinically well recognized and can be understood as …
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Cognitive Neurostimulation: Learning to Volitionally Invigorate Mesolimbic Reward Network Activation
<p>The brain’s dopaminergic system is critical to adaptive behaviors, and is centrally implicated in various pathologies. For decades, research has aimed at better characterizing what drives the mesolimbic dopamine system and the resulting influence on brain physiology and behavior in both humans …
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Neuroprotective Effect of Human Mesenchymal Stem Cell on Dopaminergic Neurons by Anti-inflammatory Action
… neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra (SN). Numerous studies have provided evidence suggesting that neuroinflammation plays a critical role in the pathogenesis of PD. The present study was to evaluate effect of human bone marrow-derived …
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