Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 374 for “"dopaminergic"”.
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Degenerative mechanism in dopaminergic neurons
The degenerative mechanisms of dopaminergic cells in Parkinsona??s disease (PD) remained elusive even after many years of research. However, many have hypothesized that the cell deaths in PD are via apoptosis and in particularly, by the mitochondrial-mediated apoptotic pathway. As such, the purpose …
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Dopaminergic modulation of hippocampal neural circuitry
Memory is a limited resource. Therefore, the circuitry that encodes memory must filter incoming information in accordance with its perceived value. The hippocampus, the hub of the declarative memory system, may achieve memory valuation using its rich variety of neuromodulatory afferent systems. The …
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Connectivity of olfactory bulb dopaminergic interneurons
… calbindin-positive, anaxonic dopaminergic and finally axon-bearing dopaminergic interneurons. Adding to the unusual features of olfaction, all of these interneurons, except the axon-bearing dopaminergic subtype, undergo continuous neurogenesis throughout life, yet their ratios …
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Dopaminergic modulation of prefrontal cortex subpopulations
… theory to biology, we lack direct evidence for dopaminergic modulation of signal-to-noise in neuronal firing patterns in vivo and a mechanistic explanation of how such computations would be transmitted downstream to instruct specific behavioral functions. Here, we demonstrate that dopamine …
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Dopaminergic modulation of risk-based decision making
Psychopharmacological studies have implicated the mesolimbic dopamine (DA) system in the mediation of cost/benefit evaluations about effort-related costs associated with larger rewards. However, the role of DA in risk-based decision making remains relatively unexplored. The present study …
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NOVEL DOPAMINERGIC SIGNALING MODULATING HIPPOCAMPAL SYNAPTIC TRANSMISSION
Dopaminergic systems regulate many brain functions and dysfunction of dopaminergic neurotransmission is thought to underlie numerous disorders, including schizophrenia, attention deficit hyperactivity disorder (ADHD), depression and Alzheimer’s disease. In the hippocampus, a dopaminergic projection …
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Dopaminergic modulation of reward and punishment learning
Contains fulltext : 128280.pdf (Publisher’s version ) (Open Access)
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Thyrotoxic and dopaminergic effects of polychlorinated biphenyls
Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:50:44Z Item is restricted indefinitely.
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Synthetic Investigation of Natural Products Causing Dopaminergic Neurodegeneration
… dose-dependent and selective degeneration of dopaminergic neurons. These molecules represent two possible tools that can be used to explore chemotoxic induction of Parkinson’s disease. In the case of SV-6, a newly isolated metabolite, total synthesis was undertaken to confirm its structure and …
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Dopaminergic modulation of basolateral amygdala for fear extinction
… We identify sources of dopamine and modes of dopaminergic action in the BLA, by showing that BLA fear and reward neuronal populations receive topographically divergent inputs from VTA dopamine (DA) neurons and differentially express dopamine receptors. Optogenetic activation of the VTA DA …
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The Neurotoxicity of Insecticides to Striatal Dopaminergic Pathway
… which is characterized by severe loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and consequent dopamine depletion in its projecting area. In this dissertation, I evaluated the neurotoxicity of several classes of insecticides/drugs/neurotoxins to the striatal …
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Seasonal plasticity of A15 dopaminergic neurons in the ewe
… to E2 negative feedback that is mediated by A15 dopaminergic neurons that are only responsive to E2 in anestrus. Experiment 1, tested the hypothesis that synaptic input on A15 neurons varies with season by examining synapsin-positive close contacts on A15 cells using immunofluorescence and …
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Dopaminergic Genetic Contributions to Obesity in Kidney Transplant Recipients
… recipients showed that expression of some dopaminergic pathway genes was negatively correlated with weight gain. Polymorphisms in some of these genes have been linked to weight gain by others. Taken together, these results suggest that genetic variation in some dopaminergic genes may …
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Representations of Reward and Movement in Drosophila Dopaminergic Neurons
… this dual role of dopamine involves the same dopaminergic pathways. Although reward-responsive dopaminergic neurons display movement-related activity, debate continues as to what features of an individual's experience these motor-correlates correspond and how they influence concurrent …
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Linking dopaminergic physiology to working memory related neural circuitry
Working memory is the ability to hold information "online" over a delay in order to perform a task. This kind of memory is thought to be encoded in the brain by persistent neural activity that outlasts the presentation of a stimulus. Interestingly, patients with schizophrenia, a heritable …
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Developmental Resilience to Dopaminergic Vulnerability Associated With Human Immunodeficiency Virus
… observations suggest a specific vulnerability of dopaminergic neurons, yet few studies have examined the possibility that these functional impairments may be associated with dopamine-specific pathology in pediatric patients. We utilized an in vivo model to 1) examine dopaminergic molecular …
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Dopaminergic Modulation Shapes Sensorimotor Processing in the Drosophila Mushroom Body
… structure essential for olfactory learning. Dopaminergic neurons convey salient information about reward and punishment to the mushroom body in order to adjust synaptic connectivity between Kenyon cells, the neurons representing olfactory stimuli, and the mushroom body output neurons that …
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Putative changes in dopaminergic neurotransmission following nicotine induced behavioural sensitisation
… used to assess and elucidate putative changes in dopaminergic neurotransmission of behaviourally sensitised animals. If so, this improved understanding of behavioural sensitisation could provide a better understanding of the pathophysiologies of neuropsychiatric disorders and provide more insight …
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Optogenetic dissection of the dopaminergic circuitry involved in memory consolidation
… & Grace 2005) points to the critical role of dopaminergic neurons in the ventral tegmental area (VTA), but recent evidence also implicates locus coeruleus (LC) as a potential source of dopamine in the hippocampus (Smith & Greene 2012). In order to identify the dopaminergic structure(s) that …
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