Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"dopamine transporter"”.
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Molecular Characterization of Dopamine Transporter Phosphorylation and Regulation
<p>The dopamine transporter (DAT) is a presynaptic membrane phosphoprotein that terminates dopaminergic synaptic transmission by clearing dopamine (DA) back into presynaptic neuron by a reuptake process. DAT is also a molecular target for psychostimulants such as cocaine, amphetamine (AMPH) and …
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Structural Determinants for Inhibitor Recognition by the Dopamine Transporter
… and our research progress in the areas of dopamine transporter (DAT). A 3-D DAT computer model was generated in our laboratory based on the X-ray crystal structure of the bacterial leucine transporter LeuT, a distant homolog of DAT. The ability of this LeuTAa-based 3-D DAT computer model to …
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Structural Determinants for Substrate and Inhibitor Recognition by the Dopamine Transporter
… holds that cocaine inhibits DAT-mediated dopamine transport via competition with dopamine for formation of an ionic bond with the DAT transmembrane 1 aspartic acid residue 79. A recent study from our laboratory indicated that mutation of this aspartate to glutamate (D79E) had little or no …
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Dopamine Uptake Inhibition Potency Fluctuations of Cocaine at the Dopamine Transporter
Cocaine and other dopamine transporter (DAT) inhibitors block synaptic dopamine uptake by binding to the DAT. Cocaine, a powerful psychostimulant, potentiates the dopamine mediated signal transduction in the reward areas of the brain resulting in physical dependence on the drug. Amphetamines are …
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The nongenomic effects of physiological and environmental estrogens on dopamine transporter function
… regulatory machinery such as the dopamine transporter (DAT). In this dissertation we tested the rapid nongenomic effects of several physiological estrogens [estradiol (E2) estrone (E1), and estriol (E3)] and xenoestrogens (XEs), such as organochlorine pesticides [dieldrin, …
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Dopamine transporter signal in patients with schizophrenia: relevance to clinical symptoms and pathophysiology
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Functional Alterations in the Dopamine Transporter of Rodents following Self-Administration of Cocaine, Heroin and Speedball
… induce a synergistic elevation in extracellular dopamine (DA) concentrations ([DA]<sub>e</sub>) in the nucleus accumbens (NAc) that can explain the continued patterns of abuse even after seeking treatment for heroin addiction. To further delineate the mechanism of this neurochemical synergism, in …
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Exploring The Ligand Binding Site On The Dopamine Transporter By Photoaffinity Labeling And Site-Directed Mutagenesis
<p>The dopamine transporter (DAT) is a neuronal presynaptic transmembrane protein that clears released dopamine (DA) from the synaptic space, regulating the neurotransmitter concentration and availability, DAT and the related serotonin (SERT) and norepinephrine (NET) transporters belong to the SLC6 …
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Dopamine Transporter (DAT) and Metabotropic Glutamate Receptor 5 (MGLU5) Irreversible Probes for Identifying Anti-Psychostimulant Therapeutics
Numerous behavioral studies indicate that dopamine transporter (DAT) inhibitors and metabotropic glutamate receptor 5 (mGlu5) negative allosteric modulators (NAMs) possess promising anti-addiction therapeutic properties. However, the lack of human DAT (hDAT) and mGlu5 X-ray crystal structures makes …
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Pharmacological Chaperones of the Dopamine Transporter: A Strategy for Increasing Function of Wild Type and Mutant Transporter
The dopamine transporter (DAT) is a membrane protein that is essential for regulating signaling and intracellular stores of the neurotransmitter dopamine. An array of pathological conditions have been linked to mutations in the dopamine transporter gene, including ADHD, bipolar disorder, autism, …
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Dopamine Transporter (DAT), Nicotinic Acetylcholine Receptor (nAChR), and Metabotropic Glutamate Receptor 2 (mGlu2) Irreversible Probes For Identifying Anti-Psychostimulant Therapeutics
Numerous in vitro and in vivo studies implicate that certain ligands that interact with DAT, nAChRs, and mGlu2 have tremendous potential as anti-addiction therapeutics. However, understanding how these promising anti-addiction compounds interact with their major drug targets at the molecular level …
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Effects of chemogenetic inhibition of dopamine transporter- or A2A-expressing neurons on spontaneous activity and motivation to consume a palatable food reward
<p>Dopamine (DA) transmission in the striatum influences the motivated pursuit of rewarding stimuli. Pharmacological and opto- and chemo-genetic studies have suggested that the release of DA onto D2+/A2A+-expressing striatopallidal neurons, plays a role in this process. To determine the potentially …
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Synthesis and Biological Evaluation of Novel GBR 12909 Tropane and Azetidine Hybrid Analogues
The high affinity, selective dopamine transporter ligand GBR 12909 has served as a template for the design of two novel classes of dopamine transporter ligands. A series of 3-[2- (diarylmethoxyethyidenyl)]-N-substituted tropane derivatives were synthesized and the binding affinities of these …
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Design and evaluation of novel PET and SPECT tracers for imaging the monoamine system and the P-gp transporter
… being the monoamine system and the P-gp transporter, were developed and evaluated in vivo. The first objective of this thesis was the design of radiotracers for the monoamine system more specifically, the norepinephrine transporter, monoamine oxidase and dopamine transporter which are all …
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Molecular genetic investigation of autosomal recessive neurodevelopmental disorders
… function mutations in the gene encoding the dopamine transporter (SLC6A3). Subsequent acquisition of a cohort of similarly affected children allowed detailed clinical and molecular characterisation of this novel disorder, dopamine transporter deficiency syndrome. Finally I have delineated the …
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Development of Receptor-Targeted Imaging Agents: Integrated Gallium Complexes and Conjugated Cyclopentadienyl Tricarbonyl Rhenium and Technetium Complexes
… analogs with high affinity for the dopamine transporter (DAT) would provide a useful tool for imaging disorders in this transporter system, such as clinical diagnosis of Parkinson's disease. The Direct Double Ligand Transfer (DLT) reaction was developed and utilized in the …
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Synthesis And Evaluation Of Novel Tropane Compounds As Potential Therapeutics For Drug Abuse
… was synthesized and evaluated for in vitro dopamine and serotonin transporter affinities. These unique 3ƒÀ-aryl-3ƒ¿-arylmethoxytropane analogues incorporated the structure of dopamine selective 2-substituted-3-phenyltropanes and the design of serotonin selective meperidine derivatives. In …
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Serotonin transporter import
… neurotransmission and members of this family of transporters are a popular target in the treatment of depression, addiction, obsessive compulsive disorder, and generalized anxiety disorder including the serotonin transporter and the dopamine transporter. These transporters have been the targets …
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