Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"dopamine neuron"”.
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A role for Dopamine neuron NMDA receptors in learning and decision-making
Midbrain dopamine has demonstrated roles in locomotion, motivation, associative learning, habit formation, action selection and cognition. The many functions of dopamine can be attributed to the multiple projection targets of midbrain dopaminergic nuclei and to the multiple characteristic modes of …
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Identification of dopamine neuron progenitors in the embryonic midbrain and stem cell cultures - Studies on the role of neuronal subtype and differentiation state for cell replacemen in a rodent model of Parkinson's disease
… (PD) is a neurodegenerative disorder where the dopamine producing neurons in the ventral mesencephalon (VM) progressively die and result in symptoms such as resting tremors, muscle rigidity, slowness and difficulties in initiating movements.Currently there is no cure for PD and the available …
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Exercise induced neuroprotection in spontaneuosly running rats
… after unilateral lesions with 6-hydroxydopamine. Rats were divided into runners (had access to running wheel) and non-runners (their running wheels were immobilised). Two weeks after injection of the neurotoxin, the rats were injected with apomorphine and the number of ipsilateral and …
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Simulating the Affects of Glutamatergic Afferents on the Firing Pattern of Midbrain Dopamine Neurons
A computational model of a midbrain dopamine neuron was extended in this study to include a response to random excitatory afferent input by incorporating the receptor components AMPA and NMDA. In a diagonal band where average glutamatergic and tonic gabaergic input is roughly balanced, both single …
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FUNCTIONAL ROLES OF MIDBRAIN DOPAMINE NEURONS IN ASSOCIATIVE LEARNING
Dopamine signaling is thought to play a critical role in reward-related learning, and the predominant hypothesis proposes that dopamine neurons signal the expected reward values of sensory stimuli in the form of a short-latency phasic burst. Thus, the reward prediction hypothesis assumes that …
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Investigations into the Neuroprotective Effects of Osteopontin in In Vitro and In Vivo Models of Parkinsons Disease
… found in brain, is reduced in the surviving dopamine-containing neurons in the SN (SN) in Parkinson’s disease (PD). OPN prevents the death of dopaminergic neurons in cell culture and animal models of PD. This effect may be mediated through interactions between the RGD binding domain of OPN …
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The Role of ERK5 in Dopamine Neuronal Survival
… roles in neurogenesis, neutrite outgrowth, and neuronal viability in the central nervous system. In this study, ERK1, 2, and 5 expression and activation were examined in the substantia nigra (SN), striatum (STR), and ventral tegmental area (VTA) during postnatal development and normal aging …
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Effects of MPTP, MPP(+) and Adreno-Medullin on Dopamine Metabolism in the Rat Corpus Striatum
… selective destruction of the nigrostriatal dopamine neuron and severe motor impairments. That peripheral administration of a single substance selectively destroys the nigrostriatal dopaminergic system and produces symptoms and pathology comparable to parkinsonism has ignited a lot of …
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Neuronal and Mitochondrial Protection in Chronic Parkinsonism
… studies linking mitochondrial dysfunction to neuronal degeneration have been carried out in vitro or in acute in vivo studies. It is not known whether mitochondrial dysfunction is an immediate response to cytotoxic-inducing agents or is sustained as a long-term consequence of neuronal death. …
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The role of the immune system in Parkinson’s Disease: from neuropathology to treatment.
… disorder characterised by progressive loss of dopaminergic neurons (DAn) in the substantia nigra. In the first part of this thesis (chapters 3-4) I describe the immune characterisation of a human embryonic stem cell (hESC)-derived dopamine neuron progenitor cell (NPC) ahead of its use in the …
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Neuronal and Molecular Adaptations of GABA Neurons in the Ventral Tegmental Area to Chronic Alcohol
… excitability and molecular adaptation of GABA neurons of the ventral tegmental area (VTA). GABA neurons are of interest with regards to ethanol intoxication, reinforcement, and dependence due to their widespread distribution and connectivity to mesocorticolimbic dopamine (DA) neurons implicated …
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CELL REPLACEMENT THERAPY FOR PARKINSON’S DISEASE: The importance of neuronal subtype, cell source and connectivity for functional recovery
… symptoms is the selective loss of mesencephalic dopaminergic (mesDA) neurons, located in the substantia nigra (SN). These neurons project axons to the striatum where they release dopamine, a neurotransmitter that controls voluntary movement. Current drug treatments restore the lost dopamine, …