Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"dopamine levels"”.
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The Effect of Cholecystokinin Antagonist Lorglumide on Dopamine Levels in the Rat Caudate
… been shown to block voltammetrically detected dopamine (DA) signals associated with slow wave depolarization (SWD) in the rat caudate (CPu). Failure to elicit KC1-induced DA signals following lorglumide treatment may be due to a CCK-DA interaction. This possibility was investigated in this …
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Neurochemical Measurements in Rodents that Model Huntingtion's Disease and Oxidative Stress
… We used fast-scan cyclic voltammetry to measure dopamine release and reserve pool dopamine in genetically and chemically altered rodents that model HD. Genetic HD model mice and rats (R6/1 mice, R/2 mice, and HDtg rats) showed an age-dependent decrease in dopamine release in the dorsolateral …
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Alcohol-induced Locomotor Activity in Zebrafish is Mediated by Activation of the Dopaminergic System
… locomotor activity and whole-brain dopamine levels. We found that zebrafish developed tolerance to alcohol's effect on locomotor and dopaminergic activity when continuously exposed to alcohol, highlighting the importance of the dopaminergic system. We correlated the alcohol-induced …
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The Effect Of An Intermittent Manganese (ii) Exposure On The Striatal Dopamine System
… and Parkinson's disease are most likely due to dopaminergic alterations in the basal ganglia. Understanding the neurobiological consequences of overexposure to Mn is critical to develop better treatment strategies. The principle objective of this research is to study the impact of Mn exposure on …
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5-HT3 Receptor Ligands and Their Effect on Psychomotor Stimulants
… of the rewarding effects produced by increasing dopamine levels. 5-HT3 serotonin receptors have been shown to indirectly affect dopamine levels. Therefore, the effect of the 5-HT3 receptor partial agonist, MD-354, on the actions of psychomotor stimulants was analyzed in mouse locomotor activity …
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Putting 'Dopamine Overdose' To The Test: A Psychopharmacological Investigation in Parkinson's Disease and Healthy Volunteers
Dopaminergic therapy prescribed to address motor symptoms in Parkinson’s disease (PD) is done at the expense of some cognition functions. It has been hypothesized that whether a given function is improved or impaired by medication depends on the baseline dopamine levels within underlying brain …
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Effects of blockade of muscarinic receptors in the ventral tegmental area : attenuation of cocaine reward, but enhancement of locomotor activity and dopamine overflow in the nucleus accumbens
… techniques were used to assess extracellular dopamine levels in the shell of the nucleus accumbens, the terminal region for mesolimbic dopamine neurons originating in the ventral tegmental area. The injection of atropine methyl nitrate into the ventral tegmental area elevated extracellular …
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Biogenic Amines and Division of Labor in the Honey Bee Society
Brain levels of biogenic amines, dopamine, serotonin, and octopamine, were measured in relation to both age-related division of labor and differences in task specialization, independent of age, in honey bee colonies. There were distinct differences associated with age-related division of labor. …
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ETHANOL INHIBITION OF DOPAMINE TRANSMISSION IN ANIMAL MODELS OF ALCOHOL ABUSE LIABILITY
Mesolimbic dopamine neurons, originating in the ventral tegmental area (VTA) and projecting to the nucleus accumbens (NAc), have been heavily implicated in the reinforcing and rewarding properties of natural and drug rewards and cues that predict these rewards. Ethanol's effects on dopaminergic …
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Cell model of DJ-1-associated Parkinson’s Disease
… loss of motor function resulting from dopaminergic neuronal death in the substantia nigra pars compacta leading to subsequent decreased striatal dopamine levels. The majority of PD cases are diagnosed as sporadic in nature, however 10% - 15% of patients show a positive family history of …
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Testing the efficacy of LSN2463359, a metabotropic glutamate 5 receptor positive allosteric modulator, in animal models of schizophrenia
… cause of schizophrenia was focused on elevated dopamine levels found in critical areas of the brain. Recently a new theory has emerged pointing to elevated glutamate levels resulting from hypofunction of NMDA receptors and hypoactivity of GABAergic neurons which normally inhibit glutamatergic …
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Diverse Kappa Opioid Receptor Agonists: Relationships Between Signaling and Behavior
… Activation of the KOR causes a decrease in dopamine levels in reward-related regions of the brain, and can block the rewarding effects of various drugs of abuse, making it a potential drug target for addictive diseases. KOR agonists are of particular interest for the treatment of cocaine and …
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Assessment of sex differences and amphetamine on schedule-induced polydipsia
… pharmacological effect is to increase synaptic dopamine levels in the mesolimbic reward pathway, which in turn causes behavioral effects in animals, and subjective effects in humans. These reinforcing properties of AMPH trigger very strong levels of craving the drug, and eventually result in …
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Study on the Neuroprotective Effects of Ethyl pyurvate in MPTP-induced Mouse PD Models
… (EP) promotes the survival of nigrostriatal dopaminergic (DA) neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease. MPTP induced degeneration of nigrostriatal DA neurons and glial activation as visualized by tyrosine hydroxylase, macrophage …
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Blood and Lumbar Fluid Biomarker Changes in Patients with HIV-Associated Neurocognitive Impairment Treated with Lithium: Analysis from a Randomised Placebo-Controlled Trial
… degeneration. Investigated biomarkers included dopamine, BDNF, neurofilament light chain, and CD8+ lymphocyte activation (CD38+ HLADR+). Alzheimer's Disease (AD) biomarkers included soluble amyloid precursor protein alpha and beta (sAPPα/β), Aβ38, 40, 42, and ten other biomarkers validated as …
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Estrogen and Antiestrogen Action in the Medial Basal Hypothalamus and Pituitary: Dopamine-Prolactin Interrelationships (d-2 Receptors, Bromocriptine)
The actions of estradiol and antiestrogens on dopamine turnover and prolactin levels were studied in the medial basal hypothalamus (MBH), anterior pituitary, and serum of immature female rats. Estradiol increased MBH dopamine levels and turnover and pituitary and serum prolactin concentrations in a …
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Effetto nell’auto-somministrazione dell’agonista sintetico del recettore cannabinoide CB1, WIN 55,212-2, nel modello animale di depressione della bulbectomia olfattoria (OBX)
… was shown to be associated to an increased dopamine transmission in the shell of the nucleus accumbens (NAc) (Fadda et al., 2006), we used the in vivo microdialysis technique to test whether OBX and SHAM rats displayed similar increase in dopamine levels within the NAc shell in response to a …
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Interactions of Early-life Temperature Exposure, Offspring Genotype and Maternal Care on Later-life Maternal Care Provisioning in Female Rats
… with alterations in the oxytocinergic and dopaminergic systems in the maternal brain and, in turn, maternal care received by pups can alter oxytocinergic and dopaminergic systems in the rat pup brain. Though there has been progress in elucidating the biological mechanisms underlying the …
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Expectation, the placebo effect and Parkinson's disease : an investigation using high-resolution positron emission tomography
… expectation of symptom improvement stimulates dopamine release in the striatum. In the work described in this dissertation, positron emission tomography with [¹¹C] raclopride was used to investigate the relationship between the strength of expectation of benefit and the degree of dopamine …
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Dynamics of La Crosse virus: Surveillance, Control and Effect on Vector Behavior
… on mosquito host-seeking and neurotransmitter levels, and 3) to determine the effectiveness of barrier sprays to control infected mosquito vectors. Our surveillance study demonstrated the involvement of an invasive species, Aedes japonicus, in the transmission cycle of Cache Valley virus (CVV). …
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