Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"dopamine D3 receptor"”.
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THE ROLE OF DOPAMINE D3 RECEPTOR IN ALCOHOL ADDICTION AND SCHIZOPHRENIA
Dopamine (DA) modulates several essential functions of the central nervous system (CNS), including reward and cognition. The dopaminergic neurotransmission in the CNS is mediated by two different classes of G protein- coupled receptors (GPCR), the D1R-like receptors (D1R and D5R) and D2R- like …
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Role of Dopamine D3 receptor in the regulation of memory related genes
Dopamine is postulated to be a key neurotransmitter that mediates human memory via signaling in the striatum, hippocampus and prefrontal cortex. The effects of dopaminergic system crucially depend on the different subtype of dopamine receptors involved and the brain regions in which they are …
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In Silico-Guided Design of Novel-Scaffold Therapeutics Targeting the Dopamine D3 Receptor
… determining the 3D structures of relevant drug receptors in the brain. A new computational technique, de novo fragment-based drug design (DFDD), was evaluated employing a dopamine D3 receptor (D3R) crystal structure. Three DFDD approaches - scaffold replacement, ligand building, and MedChem …
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Implications of dopamine D3 receptor for glaucoma: in-silico and in-vivo studies
… there are some interesting G protein coupled receptors (GPCRs) such as dopaminergic receptors. The work of the present thesis has been focused on GPCRs and in particular on dopamine D3 receptor as pharmacological target for ocular hypotensive drugs. Cabergoline, bromocriptine, cianergoline and …
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The Effects of Dopamine D3 Receptor Compounds on Oxycodone Self-Administration and Reinstatement in Female Cynomolgus Monkeys
… of substance abuse. Most drugs of abuse alter dopamine (DA) concentrations and recent studies indicate the DA D3 receptor (D3R) as a potential therapeutic target for OUD. In addition, sex differences have been identified in opioid pharmacology, yet few preclinical studies have examined opioid …
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THE ROLE OF DOPAMINE D3 RECEPTORS IN THE CONTROL OF ALCOHOL INTAKE
Background: Mesolimbic dopamine controls drug and alcohol seeking behavior. Stimulation of dopamine D3 autoreceptor reduces extracellular levels of dopamine. We tested the hypothesis that dopamine D3 receptor (D3R) gene deletion or its pharmacological blockade counteracts alcohol preference and …