Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"donor age"”.
-
Self-assembling peptide hydrogels promote in vitro chondrogenesis of bone marrow-derived stromal cells : effects of peptide sequence, cell donor age, and method of growth factor delivery
The inability of articular cartilage to heal after damage or disease has motivated investigation of novel cartilage tissue engineering technologies. The objective of this thesis was to advance the use of self-assembling peptide hydrogel scaffolds for cartilage repair by encapsulating …
-
Marginal donor characteristics and outcomes after liver transplantation
… and medical care mean a reduced pool of “ideal donors” and the population age is increasing rapidly over time. There is a growing need for donor livers as the number of critically unwell recipients awaiting liver transplantation increases. The extended criteria donor liver has been increasingly …
-
Diagnostik und Verlaufsbeobachtung der Proteinurie nierentransplantierter Patienten mit der SDS-Polyacrylamid-Gelelektrophorese : Vergleich der nephrotoxischen Einflüsse der Immunsuppression - Ciclosporin A versus FK 506 (Prograf) -
… influence of the two immunosuppressive agents, Ciclosporin A and FK 506, is defined and compared. The influence of donor age and time of ischaemia on the renal proteinuria is investigated. Possible application of the SDS polyacrylamide gel electrophoresis for long-term monitoring of …
-
The Assessment of Osteoinductivity of Human Allograft Demineralized Bone Matrix by <i>In Vivo</i> and <i>In Vitro</i> Assay Models
… production process, matrix characterization, and donor related factors on osteoinductivity of the DBM.</p> <p>Athymic mice were chosen as the animal model for use in the <em>in vivo</em> bioassay. Implantation of DBM in muscle pouches provided for much higher osteoinductivity (remineralization to …
-
Tensile Material Properties of Human Costal Cartilage Perichondrium
Rib and costal cartilage fractures are the most common injuries resulting from blunt thoracic loading scenarios, including motor vehicle collisions. The costal cartilage is a cylindrical hyaline cartilage composed of two layers: a core interstitial matrix enveloped by the perichondrium. The …
-
Characteristics of organ donors and logistics of organ procurement for short- and long-term outcomes in abdominal organ transplantation
… a graft that is usually received from an organ donor. Solid- organ transplantation is the best treatment option especially in end-stage kidney and liver failure. Pancreas transplantation, on the other hand, is the only curative treatment for Type I diabetes. To this day, most organs are gifted …
-
The Quantitative Assessment of Osteoinductivity of Human Demineralized Bone Matrix and cDNA Array Analysis of Osteogenic Differentiation in Human Periosteal Cells
… with the highest extractability of BMP-4. In the donor age study, the BMP-4 content in the protein extracts of DBM appears to be age-dependent, with DBM from younger donors being most likely to have greater BMP-4 quantity.</p> <p>In the <em>in vitro</em> dose-response studies, DBM-conditioned …
-
Mechanical and Biologic Impact of Dynamic Loading on Bovine and Human Models of Osteoarthritis
… (OA), a disease characterized by cartilage degradation. Additionally, dynamic loading has been demonstrated to affect chondrocyte metabolic activity, with mechanical stimuli acting as a therapeutic at specific amplitudes and frequencies. The goal of this thesis was to investigate the …
-
Novel Cryoprotective agents to improve the quality of cryopreserved mammalian cells
… tissues and organs. The use of cryoprotective agents (CPAs) in combination with extremely low temperatures is mandatory for optimum biopreservation. CPAs (e.g., glycerol, trehalose, dimethyl sulphoxide (DMSO)), however, are relatively cytotoxic and compromise biopreserved cell quality. This is …
-
Cytogenetic Analysis Of Depleted Uranium Exposure And Age-Dependent Susceptibility To Ionizing Radiation
… (U) body burden by measuring chromosome damage in peripheral blood lymphocytes with the cytokinesis blocked micronucleus assay (CBMN) and fluorescence in situ hybridization (FISH) whole chromosome painting. Study subjects are Gulf War I Veterans exposed to DU during friendly fire incidents …
-
Characterisation of T cell responses to proteins expressed during Human Cytomegalovirus latency
… in a large cohort of HCMV seropositive healthy donors. My results show that these viral gene products are also recognised by CD4+ T cells and are composed of distinct cellular populations secreting either IFN$\gamma$ or IL-10. The high sensitivity of this assay has also revealed previously …