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Showing 1 to 8 of 8 for “"domino reaction"”.
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Cascade Annulation and Ring-Opening Reactions of Castagnoli-Cushman-Derived Allylic and Benzylic Thiomorpholinonates
… precursor. When a DOS features a cascade or domino reaction in the key steps, the process becomes even more cost- and time-efficient. In this embodiment, a transition metal-free, base-mediated cascade reaction featuring methylesterification of allylic thiomorpholinonyl acids and concomitant …
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New Methods for the α-Functionalization of Thioesters and Activated Hydrazones and an Application Toward the Total Synthesis of Apratoxin D
<p>Cascade reactions, also referred to as domino reactions, have been widely used for the formation of carbon-carbon bonds. This type of reaction has the potential to circumvent protection and deprotection steps, shortening an overall synthetic process.</p><p>The Morita-Baylis-Hillman (MBH) …
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Fused and spiro furanones from tetronic acid synthons: Oxa and azacycles featuring the butenolide ring
Diverse 4-O-allyl tetronates were obtained by reaction of allyl (alpha-hydroxy)carboxylates with keteneylidenetriphenylphosphorane (Ph3PCCO) in a domino reaction (addition – Wittig olefination) and by direct allylation of tetronic acid via Fischer esterification. 3-Allyl tetronic acids were …
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The development and synthetic applications of Ti- and Pd-catalyzed processes
… of this chemistry, we also developed a one-pot domino reaction of 2-bromoanilines with P,y-unsaturated ketones for the preparation of indolines. Further, use of the chiral ligand DTBM-SegPhos allows for asymmetric induction with excellent levels of enantioselectivity.
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Rhodium-catalyzed Asymmetric Carbon-Carbon Bond Formation Leading to the Development of Rhodium/Palladium Multi-metal Catalysis
… and palladium catalysis in the development of domino reactions. The contents are divided into 4 chapters. Chapter 1 describes the rhodium-catalyzed asymmetric ring opening (ARO) of strained bicyclic alkenes using silyl enolates. The development of this method achieved a highly enantioselective …
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NATURAL PRODUCT INSPIRED METHODOLOGIES: ADVANCES IN DIASTEREOSELECTIVE N-SULFINYL IMINE AND TRIFLUOROPYRUVIC ACID REACTIONS
… a good understanding of the diastereoselective reaction with NSMD and NSMEs, I joined with Dr. Po-Cheng Yu to develop a highly diastereoselective domino Michael/Michael/Mannich reaction for the concise total synthesis of (+)- epiibogamine. The domino reaction enabled us to set all the …
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Asymmetrische Synthese ausgehend von allylischen Sulfoximinen: neuartige Gamma-Aminosäuren und cyclische Aminosulfoxonium Ylide
… steps were a titanium mediated hydroxyalkylation reaction under selective construction of two stereo centers and a double bond, a highly diastereoselective aza-Michael-cyclisation and the creation of the acid moiety by oxidative degradation of a furan ring. The employed chiral auxiliary …
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Asymmetrische Organokatalyse zu Alpha-Fluorierung von Aldehyden und Ketonen und zur Synthese von Cyclohexencarbaldehyden via Dominoreaktionen
… capable to catalyze a broad variety of different reactions, which explains increasing application of these catalysts in organic synthesis. In particular, amine-catalyzed domino reactions can be easily designed by combination of the enamine and iminiumion activation steps to assemble complex …