Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 30 for “"domain-3"”.
-
Role of SH3 and Cysteine-Rich Domain 3 (STAC3) in Skeletal Muscle Development, Postnatal Growth and Contraction
The SH3 and cysteine rich domain 3 (Stac3) gene is expressed specifically in skeletal muscle and essential for skeletal muscle contraction and postnatal life in mice. In this dissertation project, I conducted two studies to further understand the role of STAC3 in skeletal muscle development, …
-
Role of the Sh3 and Cysteine-Rich Domain 3 (STAC3) Gene in Proliferation and Differentiation of Bovine Satellite Cells
… predicted to encode a protein containing two SH3 domains and one cysteine-rich domain. In this study, we determined the potential role of the STAC3 gene in proliferation and differentiation of bovine satellite cells. We isolated satellite cells from skeletal muscle of adult cattle and transfected …
-
Correlated long-distance dynamics modulate monoclonal antibody binding resistance in flaviviral envelope pretein domain-3: A molecular dynamics simulations study
… have been localized to the envelope protein domain-3 (ED3) of flaviviruses. Previously it was shown that regions constituting antibody binding sites of dengue-2 (DEN2) and West Nile virus (WNV) ED3 were energetically coupled with the interior of the protein. Protein-protein interactions are …
-
Roles of Growth Hormone, Insulin-Like Growth Factor I, and Sh3 and Cysteine Rich Domain 3 in Skeletal Muscle Growth
… unknown gene named SH3 and cysteine rich domain 3 (STAC3) in myogenesis. In the first study, the myogenic precursor cells, satellite cells, were isolated from cattle and allowed to proliferate as myoblasts or induced to fuse into myotubes in culture. GH increased protein synthesis without …
-
Upstream conserved sequence element that regulates TIM-3 induction in CD4+ T cell
The T cell immunoglobulin domain and mucin domain-3 (TIM-3) was discovered in Th1 and has been known as a T cell regulatory molecule. TIM-3 expression is induced by T cell activation through mechanism not yet well-investigated. In the study, I wanted to find DNA region involved in regulation of …
-
Regulation Mechanisms of TIM-3 expression in Jurkat T cells and HMC-1 cells
T cell/transmembrane, immunoglobulin, and mucin domain-3(TIM-3)는 TIM family에 속하는 분자로 마우스 Th1 세포에 특이적인 세포 막 단백질로 처음 발견되었다. 이 분자는 T 세포와 비만세포 이외에도 대식세포, 수지상세포 등 면역에 관여하는 다양한 세포에서도 발현된다고 알려져 있다. 현재까지 TIM-3가 면역 반응에서 중요한 기능을 한다는 보고가 많이 되고 있는 반면 TIM-3 발현 조절 기작에 대해서는 많이 밝혀지지 않았다. 본 연구에서는 T 세포주와 비만 세포주에서 …
-
Developing an annotated guide for collaborative planning of choral concerts based on Sawyer's eight stages of the creative process
… 2) acquiring the knowledge of the choral domain, 3) gathering information related to the specific concert, 4) taking time off from programming tasks for incubation, 5) generating ideas related to the problem statement of that particular concert, 6) combining those ideas in unexpected ways, …
-
Regulation of TIM-3 Expression in Mast cells and Monocytes
T cell immunoglobulin mucin domain 3 (TIM-3) which is a type-I membrane protein, is expressed on differentiated Th1 cell, mast cell and monocyte. Although expression of TIM-3 and its ligand galectin-9 has been demonstrated in mast cells, the transcriptional regulation of these molecules has not …
-
Constructing the Cornerstones for C.A.T.E.S.
… Nurse Practitioners (NANNP) core competency domain; 3) define the operational definitions for the novice to expert performance subscales, and 4) determine the essential scenarios to assess multidimensional competency of NNPs. The approach was a Real Time Delphi (RTD) Method, a technologically …
-
An ethnographic study exploring the experiences of women who participate in power sports.
… ideology within such a masculine sporting domain, (3) To critically explore the perceived effect of masculine sporting ideologies female in power sports affect the everyday social life of participants and (4) To examine women’s’ experience of prejudice within power sports. An ethnographic …
-
Comparing the Professional Practices of Teachers Working in a Positive Behavior Support High School with Practices of Teachers in a Traditional High School
… responsibility that are clustered into four domains: Domain 1: Planning and Preparation, Domain 2: Classroom Environment, Domain 3: Instruction, and Domain 4: Professional Responsibilities. This comparison serves as a tool to determine if there is any difference in the professional practices …
-
Identification of Regulatory DNA Region and Transcription Factors Important for TIM-3 Transcription
TIM-3는 T 세포 immunoglobulin- and mucin-domain-containing molecules (TIMs) family의 하나로서 보조 T 세포 1형에서 특이적으로 발현하는 분자로 발견되었다. 이 분자는 비만세포에서도 발현이 되며 TGF-β에 의해 발현이 증가한다고 알려졌으나 분자생물학적인 발현기작에 대해서는 연구되지 않았다. 본 연구에서는 TIM-3의 분자생물학적인 발현조절기작을 밝히기 위해 TIM-3 upstream DNA와 intron 1과 2를 각각 포함하는 luciferase reporter …
-
Duality of magmatism at Kirkland Lake, Ontario, Canada.
… is possible to identify three distinct magmatic domains defined by mode of emplacement, minerology and geochemistry. Mineral chemistry indicates that rocks from both suites evolved under oxidizing conditions in domains 1 and 3. Rare earth element compositions indicate a similar upper mantle …
-
Inactivation of Stac3 causes skeletal muscle defects and perinatal death in mice
The Src homology 3 domain (SH3) and cysteine rich domain (C1) 3 (Stac3) gene is a novel gene copiously expressed in skeletal muscle. The objective of this research was to determine the role of Stac3 in development, specifically in skeletal muscle. We achieved this objective by evaluating the …
-
Discriminative and adaptive training for robust speech recognition and understanding
… of knowledge transfer from a well-trained source domain LSTM acoustic model to the target domain. (3) To further improve the adversarial learning for unsupervised adaptation with unparallel data, domain separation networks are used to enhance the domain-invariance of the senone-discriminative deep …
-
Social movements as networks of communication episodes
… four different SMS: (1) 1970s US Energy Policy Domain, (2) 1970s US Health Policy Domain, (3) 1980s Anti-Stalinist mobilization in Poland, and (4) 1980s US Labor Policy Domain. Multidimensional network simulation was used to determine which organizing patterns correlate to instrumental and …
-
Symbolic-numeric programming in scientific computing
… in symbiosis. Our system is adaptable to any domain: users can define 1) Symbolic variables of any type 2) the set of primitive (symbolically indivisible) functions in the domain, 3) the propagation of partial information, and 4) pattern-based rewrites and simplification rules. There is a …
-
From the Unexpected to the Unbelievable: Thetics, Miratives and Exclamatives in Conceptual Space
… by the following distinctions: 1) an existential domain, 2) a presentational domain, 3) a mirative domain, and 4) an exclamative domain. Several case studies illustrating the relationships between the functions are presented. It is also demonstrated that miratives can establish a distinction …
-
Strategic Competition and Escalation Management in the 21st Century: Russian Hybrid Warfare and China’s Rise
… grayzone provocations (most notably in the cyber domain). (3) Increase domestic resilience by strengthening the electoral system, building stronger public-private partnerships, and working with the international community to increase attribution in the cyber domain. (4) Ratify the United Nations …
-
The Effect of Tim-3-Ig on Tumor Growth
… TIM (T cell immunoglobulin- and mucin-containing-domain) family of molecules, is the first molecule identified to be specifically expressed on CD4+ Th1 and not on Th2 cells. Tim-3 negatively regulates Th1 immunity and induces tolerance, but it's function has not been clarified in tumor immunity. …
Page 1 of 2