Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"domain organization"”.
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Tracing history of protein domain organization, functional loops, and dipeptides with chronologies and networks
This Dissertation was approved for publication on 2022-07-14 at 09:55.
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Regulation of receptor signaling and membrane trafficking by beta1,6-branched n-glycans and caveolin-1/cholesterol membrane domain organization
… and other regulators, such as membrane lipid domains, in the control of signaling pathways remains poorly understood. My thesis therefore focuses on how N-glycans and membrane lipid domains oppose and/or work together at different cellular levels to regulate various processes such as receptor …
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"""TSA-Seq"": a novel proximity mapping approach for studying three dimensional genome organization and function"
"The organization of chromatin and its localization in the eukaryotic cell nucleus plays a critical role in gene regulation (Agarwal and Rao, 1998; Brown, 2003; Ferrai et al., 2010) and is important for maintaining normal genome function. However, although it is known that the distribution of …
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Reconstituting APP and BACE in proteoliposomes to characterize lipid requirements for β-secretase activity
… curvature, surface charge distribution, lateral domain heterogeneity etc.) of the lipid bilayer. These collective membrane properties will influence the activity of embedded membrane proteins. In addition, activity regulation may involve a direct interaction with a specific lipid (cofactor or …
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The Interaction Between Eukaryotic Translation Initiation Factor eIF4G and 3’ Cap Independent Translation Element of Barley Yellow Dwarf Virus Is Affected by Multiple Initiation Factors
… Three eIF4G deletion mutants with different domain organization were used to investigate BTE interaction with eIF4G: eIF4G601-1196 is the eIF4G fragment containing amino acid residues from 601 to 1196, including binding domains for eIF4E, central eIF4A, eIF4B and the possible BTE binding …
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Characterization of Novel Substrates of the Tankyrase and RNF146 Destruction Complex and Mechanisms of its Regulation
… mammalian Tankyrases, Tankyrase 1 and 2, whose domain organization include ankyrin repeat clusters which mediate enzyme-substrate interactions and a SAM domain which regulates oligomerization of Tankyrase into large macromolecular complexes. Tankyrases bind to proteins through a ‘RxxxxG’ peptide …
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Characterization of DNA Binding Activities at Vertebrate Telomeres
… by contacting a bipartite DNA site with each Myb domain. The relative orientation and spacing of the two sites does not affect binding. We propose a model for TRF1 binding that predicts the existence of a flexible region, located between the highly conserved dimerization and DNA binding domains, …
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Plant natriuretic peptides - elucidation of the mechanisms of action
… kinase-like protein (AtWAKL10) that has a domain organization resembling that of vertebrate natriuretic peptide (NP) receptors was also partially characterized as a possible receptor for the recombinant AtPNP-A. Vertebrate NP receptors contain an extracellular ligand-binding domain and an …
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AN EXAMINATION OF THE DOMAIN ARCHITECTURE OF THE IOC2 AND IOC3 SUBUNITS OF THE ISW1 COMPLEXES IN SACCHAROMYCES CEREVISIAE
… the differences in subunit composition and the domain organization of these two complexes. Our work has identified and characterized novel domains within the Ioc2 and Ioc3 subunits that modulate the distinct biochemical properties of these complexes. We found that the IRD (ISW1a Regulator of …
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Lysosomes and Ribonucleoprotein Dynamics in Neurons
… a component of RNA granules, and its bipartite domain organization allows it to act as a tether between RNA granules (N-terminal phase separation) and the lysosomal surface (C-terminal phospholipid binding). We find that ANXA11 enables RNA granule hitchhiking on motile lysosomes, promoting the …
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Host-Pathogen Interactions of Secreted and Surface Staphylococcus Aureus Factors
… of staphylococcal MSCRAMMs that share similar domain organization. Interestingly, the amino-terminus, is composed of three immunoglobulin-folded subdomains (N1, N2, and N3) that contain ligand-binding activity. Clumping factors A and B (ClfA and ClfB) and SdrG are Sdr proteins that bind to …
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Linking WRP/srGAP3 to the Cognitive Deficits in 3p- Syndrome and Its Role in the Regulation of Dendritic Filopodia Formation
… WRP is a member of the srGAP family of Rho GAP domain containing proteins, which share a characteristic domain organization and are expressed throughout the brain. Recently, one of the members of this family was found to contain a newly described inverse F-BAR (IF-BAR) domain of unknown function …
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Obscurin Mediates Ankyrin Complex Formation In The Heart
<p>Distinctly organized domains of receptors, ion channels, transporters, signaling molecules, cell adhesion molecules, and contractile proteins are crucial to cardiac function. Interactions between adaptor proteins such as ankyrins and cytoskeletal proteins such as obscurin play a pivotal role in …
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Breaking the MF curse: the regulatory role of the Methyl farnesoate – MEKRE93 pathway in crustacean molting
… in the YO and contains an unconventional domain organization compared to annotated FAMeT. Nonetheless, phylogenetic analysis of each gene was overall highly conserved across pancrustaceans (and occaisionally panarthropodans). Furthermore, in vitro assays showed that C. maenas and G. …
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The role of human and Drosophila NXF proteins in nuclear mRNA export
… which are characterized by a conserved modular domain organization. This family was termed nuclear export factor (NXF) family. While the yeast genome encodes only one NXF protein (Mex67p), the genomes of higher eukaryotes encode several NXF proteins. There are two nxf genes in C. elegans and A. …