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Showing 1 to 20 of 109 for “"docosahexaenoic acid"”.
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Neuroprotective Functions of Docosahexaenoic Acid and Epidermal Fatty Acid Binding Protein
… Using NGFDPC12 cells we show that palmitic acid (PA) induces the expression of stress response genes HIF-1α and BNIP3, increases the accumulation of reactive oxygen species, and decreases cell viability by apoptosis. Inhibition of cathepsins does not rescue neurons from PA-LTx but inhibition …
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Enteral docosahexaenoic acid supplementation to attenuate inflammation in the preterm infant
… associated with disease in the postnatal period. Docosahexaenoic acid (DHA) is an omega-3 long-chain polyunsaturated fatty acid (LCPUFA) with known immunomodulatory properties, however the effect of dietary DHA on the regulation of immune responses in preterm infants is largely unknown. This …
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Nutrient-based strategies to enhance docosahexaenoic acid (DHA) utilization in the piglet brain
… tissue analysis revealed neutral lipid (NL) docosahexaenoic acid (DHA) concentrations were greater (P < 0.05) in T3-fed pigs compared with T1-fed and SR pigs. Hippocampal phospholipid (PL) DHA concentrations of T2- or T3-fed pigs were intermediate to T1-fed and SR piglets. Diffusion tensor …
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Effects of Docosahexaenoic Acid on TGF-ß and SMAD Proteins in COLO205 and WiDr Cells
… are among the proteins known to be modified by docosahexaenoic acid (DHA) treatment in T-cells. Unpublished data has indicated that these proteins may be modified by DHA in colon cancer cells. In the current project, a thorough investigation of the effects of DHA on TGF-ß and SMAD protein …
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THE PROPHYLACTIC POTENTIAL OF DOCOSAHEXAENOIC ACID, AN OMEGA-3 FATTY ACID, IN TRAUMATIC BRAIN INJURY
… prophylactic strategies. Omega-3 fatty acids (ω3 FAs), known for their anti-inflammatory and neuroprotective benefits, are highly accessible in both dietary and supplementary sources. However, the information surrounding the effect of ω3 FA supplementation on the brain in response to TBI …
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The Effects of 1,25-Dihydroxyvitamin D3, Docosahexaenoic Acid and 5-Fluorouracil on Human Breast Cancer Cells
It is well documented that vitamin D and DHA have antiproliferative effects on a variety of human cancers, including breast cancer. Studies have shown that a combination approach to cancer treatment is more effective than any one treatment administered alone. In this study, human mammary epithelial …
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Dual Receptor Uptake of Low-Density Lipoprotein Docosahexaenoic Acid (LDL-DHA) Elicits Differential Sensitivity Across Breast Cancer Subtypes
… which acts as a carrier for the omega-3 fatty acid docosahexaenoic acid (DHA). The LDL-DHA nanoparticle has demonstrated cancer selective cytotoxicity with little ill effects on healthy cells. Our research began by selecting a panel of breast cancer cell lines representative of the various …
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The effects of docosahexaenoic acid combined with supporting nutrients and physical activity on mobility and cognitive function in older women.
… and cognition in older adults, and omega-3 fatty acids and exercise share a range of overlapping biological effects. The primary aim of this thesis was to conduct a randomised semi-blinded placebo controlled study exploring the effects of a high DHA multi-nutrient supplement and aerobic exercise, …
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The role of dietary arachidonic acid and docosahexaenoic acid in preventing the phenotype observed with highly unsaturated fatty acid deficiency
… physiological roles of highly unsaturated fatty acids (HUFA), mainly arachidonic acid (AA, 20:4ω6) and docosahexaenoic acid (DHA, 22:6ω3), are not completely understood. In order to study specific functions for AA and DHA, a delta-6 desaturase knockout (D6D-/-) mouse was created. D6D is a key …
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Physical Activity-Associated Differences in Placental Lipid Profiles and Docosahexaenoic Acid Uptake: Insights from Lipidomics and an In Vitro Exercise Model
… availability, and their downstream pathways. Docosahexaenoic acid (DHA) is a fatty acid of particular importance for fetal brain and retinal development, and its proper delivery to the fetus is critical. The influence of gestational PA on these factors has not been explored. Methods: The first …
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Depletion of docosahexaenoic acid (DHA) and arachidonic acid causes male infertility by disrupting both secretory granule biogenesis and adherens junction assembly in testis
An insufficiency in omega-3 fatty acids has been linked to a wide variety of health concerns including Alzheimer’s disease, CHD, sub-optimal fetal development and male infertility. The long chain omega-3 docosahexaenoic acid (DHA) and omega-6 arachidonic acid (ARA) are highly unsaturated fatty …
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Manothermosonication (MTS) and pH-shifting combined treatment for modifying the functional properties of plant proteins: protein-stabilized nanocarriers and protection of docosahexaenoic acid (DHA)
… nanocarriers to encapsulate and protect docosahexaenoic acid (DHA). In study one, a new physical and chemical combined treatment for protein modification, i.e. mano-thermo-sonication (MTS) with and without pH-shifting was developed. This method was tested using soy protein isolate (SPI) …
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Effects of algal docosahexaenoic acid in an extruded cat diet on nutrient digestibility, fecal characteristics and metabolites, and blood coagulation parameters and fatty acid profiles of plasma and red blood cell membranes
Omega-3 polyunsaturated fatty acids (w3-PUFA), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are critical nutrients in feline diets. These nutrients are utilized as a key source of energy, in the transport of fat-soluble vitamins, in the formation of eicosanoids in …
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Systemic and Intracellular Trafficking of Long-chain Fatty Acids in Lactating Dairy Cattle
… as ration additives to provide omega-3 fatty acids to dairy cows. Supplementing dairy cows with omega-3 fatty acid-rich feeds does not easily increase quantities in milk fat of dairy cows because polyunsaturated fatty acids are biohydrogenated in the rumen. Lipid encapsulation of omega-3 fatty …
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Zinc and essential fatty acid status and supplementation in cystic fibrosis patients
… is not yet known. Zinc and essential fatty acids mutually influence each other and are important in inflammation and immunity. Chapter 2 summarises the research objectives. In chapter 3 we focus on the zinc status, first by means of the serum zinc concentration. The normal serum zinc …
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Development of Omega-3-Fatty Acid Enriched Finishing Feed and Value Added Tilapia Product
… omega-3 content specifically eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid. The objective of this study was to create an omega-3 enriching feed that would increase omega-3 content in tilapia and subsequently decrease the omega-6:3 ratio. An 8 week feeding trial was …
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The anabolic and anti-catabolic effects of long-chain omega-3 polyunsaturated fatty acid supplementation on functional muscular outcomes.
Long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) are associated with multiple benefits, primarily related to cognitive and cardiovascular health. Recently, LC n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have received considerable attention from the athletic …
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Iron and DHA in Relation to Early Cognitive Development
Iron and docosahexaenoic acid (DHA) are important nutrients for brain development. Negative effects of DHA supplementation when status of both nutrients is low have been shown on cognitive outcomes. We sought to determine if DHA status interacts with iron deficiency (ID) and influences offspring …
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Use of Omega-3 Fatty Acids to Reduce the Risk of Cardiovascular Disease in Type 2 Hispanic Diabetics in Northeast Tennessee.
… at an increased risk for CVD. Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) in fish oil have been found to reduce risk of CVD. Subjects were randomly divided into two groups and received either two grams of fish oil or corn oil (control) per day for 90 days. Before and after the …
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