Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 449 for “"dna methylation"”.
-
DNA Methylation: Methods and Analyses
… using the high-throughput, cost-effective HumanMethylation450 microarray (450k) developed by Illumina. With the recent release of the HumanMethylationEPIC microarray, the size of data is expected to increase considerably so advances are needed in the methodologies used to analyse such data. The …
-
On the Analysis of DNA Methylation
… lend support to the idea that the patterns of DNA methylation are in some way related either causally or as a readout of cell-type specific protein binding. We lay the groundwork for a framework to test whether the pattern of DNA methylation levels in a cell combined with protein binding models …
-
APPROACHING DNA METHYLATION AT THE NANOSCALE
… activities without altering the underlying DNA sequence. So far, four types of epigenetic modulation have been extensively studied: DNA methylation, histone post-translational modification, non-coding RNA, and nuclear organization. A fast-growing body of evidence suggests that epigenetic …
-
DNA methylation: the "stable" epigenetic mark
DNA methylation is regarded as a stable epigenetic mark given its faithful maintenance across successive cell divisions. Methylation occurs at most CpG sites in mammalian genomes and is generally associated with transcriptional repression. An accepted evolutionary role for DNA methylation is to …
-
DNA methylation in early mammalian development
… by epigenetic modifications, including DNA methylation. In this thesis, I analyze genome-scale DNA methylation profiles across pre-implantation development to identify the targets and characterize the dynamics of global demethylation that lead to totipotency and the subsequent changes to …
-
Tissue- specific DNA methylation profiles in newborns
… tissues are a suggested mechanism of which DNA methylation is best understood. DNA methylation profiles in human tissue are mostly performed in DNA from white blood cells. The objective of this study was to assess DNA methylation profiles of IGF2 DMR and H19 in DNA derived from four tissues …
-
REDEFINING PROMOTER DNA METHYLATION CHANGE IN CANCER
Promoter DNA methylation has been recognized for decades as one of the major mechanisms of epigenetic gene regulation and has consistently been found to be perturbed during cancer development. However, among the many genomic regions that have been found to display altered methylation in different …
-
Regulation of PAX6: DNA methylation and MicroRNAs
… of PAX6, which are microRNAs (Study 1) and DNA methylation (Study 2 and Study 3), respectively. Study 1 examines three predicted microRNA-7 (miR-7) target sites within the 3'untranslated region (3'UTR) of the human PAX6 gene. A Luciferase reporter assay demonstrates that two of the predicted …
-
DNA methylation in the early porcine embryo
… effects on the epigenetic factor of cytosine methylation in cytosine-guanine dinucleotides. The purpose of this research is to study the dynamics of DNA methylation in porcine gametes, clonal cell lines, adult somatic cells, and early embryos produced by using in vivo, in vitro, …
-
Regeneration, DNA Methylation, and Transformation in Rosaceae
The effects of different concentrations of kanamycin, carbencillin, cefotaxime, and combinations of carbencillin and cefotaxime on regeneration from different tissues of rose (Rosa hybrida cv. Carefree Beauty) were investigated. Agrobacerium tumefaciens strain GV3101 containing pCAMBIA 2301 plasmid …
-
The Effect of the Microbiome on DNA Methylation
DNA methylation is an epigenetic mark with profound impact on gene expression and regulation. It is known to be altered both in cancer and throughout aging. These aging and cancer related changes are characterized by hyper-methylation of normally unmethylated CpG islands, and global DNA …
-
CXXC finger protein 1 upregulates maintenance DNA methylation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Chromatin Structure, Dna Methylation and Vitellogenin Gene Expression
The methylation patterns and the chromatin conformation of the Xenopus vitellogenin genes were examined to determine their relationship to the transcriptional state of the genes. The role of these two potential regulatory mechanisms was of particular interest because the estrogen induction of …
-
Epigenetic modelling: DNA methylation and working towards model parameterisation
… research in this thesis is the investigation in DNA methylation mechanisms of epigenetics and the study of a specific database. As part of the latter work, the role of curation is described, and a new knowledge management system, PathEpigen1 , is reported that is currently being developed for …
-
The Role of DNA Methylation in Addiction and Depression
Despite abundant expression of DNA methyltransferases (Dnmt’s) in brain, the regulation and behavioral role of DNA methylation remain poorlyunderstood. I found that Dnmt3a expression is persistently regulated in nucleus accumbens (NAc),a key brain reward region, by chronic cocaine or chronic social …
-
Deconvolute Brain Tumor Genomic Alterations Based On Dna Methylation
… is associated with genome-wide hypermethylation of CpG islands in gliomas. But other subtype-associated alterations, including telomerase reverse transcriptase (<em>TERT</em>)<em> </em>promoter mutation, alpha thalassemia/mental retardation syndrome X-linked (<em>ATRX</em>) mutation, …
-
Effects Of Dna Methylation Pattern On The Chromatin Structure
<p>DNA methylation plays an essential role in various biological processes such as stem cell differentiation, imprinting, X-chromosome inactivation, etc. Increased DNA methylation levels have been associated with chromatin compaction leading to gene silencing. For example, abnormal DNA methylation …
-
THE ROLE OF DNA REPAIR IN DNA METHYLATION DYNAMICS
… involves the erasure and re-establishment of DNA methylation by both passive and active mechanisms, including DNA repair pathways, and occurs concurrently with an increase in developmental potency. In addition to Uhrf1 and the Tet enzymes, the interplay between activation induced cytidine …
-
Dynamics of DNA methylation and genomic imprinting in arabidopsis
DNA methylation is an epigenetic mark that is highly conserved and important in diverse cellular processes, ranging from transposon silencing to genomic imprinting. In plants, DNA methylation is both mitotically and meiotically heritable, and changes in DNA methylation can be generationally stable …
-
Dynamic regulation and functions of locus-specific DNA methylation
The role and regulation of DNA methylation at various genetic elements have gathered tremendous interest over decades. The methylomes of many cell types have been described, revealing a dynamic and tissue-specific pattern of DNA methylation (tissue-specific differentially methylated regions, …
Page 1 of 23