Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"dksA"”.
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Uncovering the Redox Potential of the Global Gene Regulatory Protein DksA in Borrelia burgdorferi
… component is the global gene regulatory protein DksA, which is responsible for reducing the expression of housekeeping genes during the stringent response, while promoting the expression of virulence genes during infection. The mechanistic details of how DksA is able to sense environmental …
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Relative contributions of the stringent response mediators (p)ppGpp and DksA to Haemophilus ducreyi virulence in humans
… [(p)ppGpp] and the transcriptional regulator DksA. (p)ppGpp and DksA jointly interact with RNA polymerase to regulate genes critical for bacterial survival. We hypothesized that the stringent response is required for H. ducreyi virulence in humans. A ΔrelAΔspoT mutant, which is unable to …
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Characterization of Bacterial Transcriptional Regulatory Networks through Genome-Wide in vitro Run-Off Transcription RNA-Seq (ROSE)
… mechanism in E. coli K-12 MG1655. The protein DksA and the alarmone ppGpp were added to extend the ROSE method, resulting in 2,205 TSS with differential transcription activity of at least twofold in the presence of DksA+ppGpp. Out of these, 1,387 TSS showed a positive regulation, and 818 TSS …
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Novel pleiotropic regulators of flotation, secondary metabolite production, and virulence in Serratia sp. ATCC 39006
… factor σ54 (rpoN), and a transcription factor (dksA). The waaL mutant exhibited increased transcription and expression of GV genes but was unable to float. Pleiotropic effects of the transposon insertion included an increase in carbapenem production and a decrease in motility and virulence in a …
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Cryo-EM Studies of Bacterial RNA Polymerase
… the alarmone ppGpp, and the transcription factor DksA. Unlike most transcription factors, ppGpp and DksA bind directly to RNAP but not to DNA. Another transcription factor, TraR, regulates RNAP the same way as ppGpp and DksA. TraR, and ppGpp/DksA, can activate or inhibit transcription initiation …
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Stress And Survival Of Enterobacteriaceae: Studies Of Dehydration Tolerance And Polymyxin Resistance
… including the transcriptional regulator DksA and the general stress response regulator RpoS. In addition to studying dehydration tolerance, we investigate resistance to polymyxins, which are cationic antimicrobial peptides used as last-resort antibiotics in Gram-negative bacteria. The …
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Dynamic key scheduling algorithm for block ciphers using quasigroup string transformation
… a Dynamic Key Scheduling Algorithm (DKSA) is developed. To validate the findings, non-associativity of the generated isotopes has been tested and the generated isotopes appeared to be non-associative. Furthermore, the proposed KSA algorithm has been validated using the randomness test …
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Key schedule algorithm based on coordinate geometry of a three-dimensional hybrid cube
… HiSea, and Dynamic Key Schedule Algorithm (DKSA). The proposed KSAHC algorithm has been validated using the randomness test proposed and recommended by NIST, the average result of avalanche test is 93%, entropy is 0.9968, correlation assessment test is -0.000601 and having large key space …
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Characterisation of pleiotropic regulators of gas vesicle biogenesis, antibiotic production, motility and virulence in Serratia sp. ATCC 39006
… factor σ 54RpoN, and the transcription factor DksA. The regulation of GVs and secondary metabolites in S39006 can be coordinated but such pleiotropy is still poorly understood. PigP (an XRE family transcriptional regulator) and Rap (regulator of antibiotic production, a SlyA transcriptional …
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Posttranscriptional and posttranslational regulation of virulence in erwinia amylovora
… in the ppGpp-deficient mutant and the dksA mutant, but up-regulated when the wild-type strain was treated with serine hydroxamate, suggesting that ppGpp might induce hrpX/hrpY and hrpS expression. Furthermore, CsrA positively regulates hrpS expression mainly through the Rcs system. …