Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"disulfiram"”.
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Investigation of the anti-breast cancer efficacy and mechanisms of disulfiram
… important in clinic for cancer patients. Disulfiram (DS) is a commercially available anti-alcoholism drug with strong cytotoxicity in a wide range of cancer types and has a reversing II effect on chemoresistance. In this study, the anticancer efficacy of DS on cancer cell lines and CSCs …
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Investigation of the anticancer activity and molecular mechanisms of Disulfiram in Glioblastoma Multiforme
… stemness in GBM cells. In this study, we used Disulfiram (DS), an anti-alcoholism drug, in combination with copper (Cu) to target the hypoxia-NF-B axis and inhibit ALDH activity to reverse chemoresistance in GBM CSCs. We showed that DS/Cu is cytotoxic to GBM cells and completely eradicated the …
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Investigation of the effect of disulfiram on the chemoresistance and invasiveness in pancreatic cancer cells
… an emerging drug R&D strategy in recent years. Disulfiram (DS) is an anti-alcoholism drug used in clinic for over 60 years. It demonstrates excellent activity against a wide range of cancers such as glioblastoma, non-small cell lung cancer and, head and neck squamous cell carcinoma without …
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An electrophoretic study of fetal mouse brain proteins after in vivo exposure to phenytoin and disulfiram
Although there have been two-dimensional electrophoretic studies on fetal brain tissue (for instance, Yoshida and Takahashi, 1980), the emphasis in most of this work has been on developmental changes in protein expression, and not on the effects that drugs have on fetal brain protein complement. …
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Investigation of Carbamathione Pharmacokinetics and Pharmacodynamics by In Vivo Microdialysis and Capillary Electrophoresis
The pharmacological basis for the use of the drug disulfiram for alcoholism is its inhibition of liver aldehyde dehydrogenase (ALDH2). Recent studies have reported that disulfiram exhibited an anti-craving effect with both alcohol addiction and cocaine dependence. Inhibition of ALDH2 cannot explain …
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In vitro and in vivo investigation of the anticancer activity and mechanism of disulfiram in malignant mesothelioma
… to expedite patient access at a lower cost. Disulfiram (DSF), a Dithiocarbamate-based drug used for the treatment of alcoholism, has shown potential anticancer effects in combination with metal ions (Cu, Zn), primarily due to its ability to generate reactive oxygen species (ROS), inhibit …
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In vitro and in vivo investigation of the anticancer activity and molecular mechanisms of disulfiram in non-small cell lung cancer
Background: This study aims to repurpose disulfiram (DS), a drug used to treat alcohol dependence, into an effective treatment for non-small cell lung cancer (NSCLC). Lung cancer is the leading cause of cancer related death worldwide because of early metastasis and chemoresistance. Cancer stem …
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Investigation of chemoresistant mechanisms in triple negative breast cancer cell lines and development of a nano-enabled Disulfiram for breast cancer treatment
… of clinical significance for TNBC treatment. iv Disulfiram (DS) is a commercially available anti-alcoholism drug. Recent studies demonstrate that it is highly cytotoxic in a wide range of cancer types and potentially repurposed as an anticancer drug. The anticancer mechanisms of DS were …
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In vitro investigation of the effect of disulfiram on hypoxia induced NFκB, epithelial to mesenchymal transition and cancer stem cells in glioblastoma cell lines
… and local infiltration. In this study, we used Disulfiram (DS), a drug used for more than 65 years in alcoholism clinics, in combination with copper (Cu) to target the NFκB pathway, reverse chemoresistance and block invasion in GSCs. The obtained results showed that DS/Cu is highly cytotoxic to …
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Copper ionophores induce autophagy in melanoma cells.
… of stress. In this study, two copper ionophores, disulfiram and thiomaltol, were investigated against melanoma. By using immunocytochemistry, Western Blotting and supravital staining, it was confirmed that both ionophores induce autophagy, and furthermore, drive the process to completion. In …
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Mercaptursäure und Nukleosidaddukt im Harn als Biomarker in 1-Hydroxymethylpyren-exponierten Ratten
… von HMP beteiligt waren. Die Inhibitoren Disulfiram und Ethanol der o. g. Enzyme wurde daher zur Modulation der Detoxifizierung in vivo eingesetzt. Die Veränderungen in der Toxifizierung von HMP zu SMP wurden durch die SMP-Konzentration im Plasma, die DNA-Addukthäufigkeit und die …
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Therapieprozess- und Ergebnisforschung in der Ambulanten Langzeit-Intensivtherapie für Alkoholkranke (ALITA)
… Medikamentes versus Einnahme des Verum-AA (Disulfiram / Calciumcarbimid), (2) bewältigte Lapses versus unbewältigte Lapses versus vollständige Relapses und (3) reguläre Dauer der AA-Einnahme von 13 bis 20 Monaten versus Langzeiteinnahme von über 20 Monaten.Ergebnisse: In dieser …
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Analysis of gene expression alterations in premalignant progression from normal mammary epithelium to ductal carcinoma in situ by multiple orthogonal tools
… three DCIS models. Further, two different drugs, disulfiram and valproic acid, that target ALDH5A1 significantly inhibited growth and proliferation in the DCIS models, but had minimal effect on MCF10A. Our results suggest that ALDH5A1 may play an important role in DCIS and additional studies are …
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PLGA-DS reverses chemoresistance in malignant mesothelioma by targeting hypoxia induced cancer stem cells
… treatment. Our previous studies have shown that Disulfiram (DS), a clinically used anti-alcoholism drug, in combination with Copper (II) (Cu) has substantial toxicity in CSCs in a wide range of cancer types. The clinical application of DS in Cancer is limited by its very short half-life (< 2 …
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Desarrollo de ribozimas de horquilla y martillo para disminuir la actividad de la deshidrogenasa aldehídica mitocondrial (ALDH2) de rata
… generar una aversión al consumo de alcohol con disulfiram. Este fármaco inactiva eficazmente la deshidrogenasa aldehídica mitocondrial (ALDH2), pero es muy tóxico. Una alternativa terapéutica es imitar el efecto del disulfiram silenciando el mRNA de la ALDH2 con ribozimas, RNAs catalíticos …
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Mechanismen der Apoptose in proximalen Tubulusepithelzellen der Niere (LLC-PK1) : ein pathophysiologisches Modell für das hämolytisch-urämische Syndrom (HUS)
… führte eine gleichzeitige Behandlung mit Disulfiram (Tetraethylthiuram Disulfid), einem konzentrationsabhängigen Inhibitor der Caspase-3, in LLC-PK1-Zellen zu einem signifikant geringeren Anteil apoptotischer Zellen (Stx1: -19%, p<0,001 bzw. Stx2: -18,5%, p=0,04). <br>Diese zytoprotektiven …
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In vitro investigation of the anticancer activity and molecular mechanisms of action of albumin nano-encapsulated copper/zinc diethyldithiocarbamate in human pancreatic cancer cells
… the need for novel, effective therapies. Disulfiram (DSF), an FDA-approved anti-alcoholism drug, has demonstrated potent anticancer activity when chelated with Cu²⁺ or Zn²⁺ ions to form copper diethyldithiocarbamate (Cu(DDC)₂) or zinc diethyldithiocarbamate (Zn(DDC)₂). However, the …
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Investigation of anticancer activity and mechanisms of Meso- 2,3-dimercaptosuccinic acid (DMSA) in glioblastoma cell lines
… Previous studies from our group have shown that Disulfiram (DS), an FDA approved anti alcoholism drug has excellent anticancer activity against a wide range of cancers with its metal binding capability through its unique dithiol structure. Hence our group is interested in identifying clinically …
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Nuclear Factor Kappa B Pathway and human cancer therapeutics
… study manifested that the anti-alcoholism drug, Disulfiram (DS), and anti-inflammatory drug, triptolide (PG490), markedly enhanced the cytotoxicity of several conventional anti-cancer drugs in colon, lung and breast cancer cell lines. PG490 induced caspase-dependent cell death accompanied by a …
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Investigation of the anticancer activity and mechanisms of zinc diethyldithiocarbamate in multiple myeloma
… that is more viable in terms of costs and time. Disulfiram (DS), an anti-alcoholism drug used in the clinic for over 70 years, demonstrates excellent specific anticancer activity with no/low toxicity to normal tissues. DS chelates with transition metals such as copper and zinc to form …
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